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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)76
The number (and %) of the onco-proteins29 (38.16 %)
The number (and %) of the tumor suppressors7 (9.21 %)
Total number of binary PPIs (saturation %)367 (12.88 %)
The number (and %) of affected PPIs76 (20.71 %)
The number of possible different fusions13
PPI diameter2
PPI radius1
The average degree of PPI8.947
Assortativity coefficient-0.2645
The network average Clustering coefficient0.618
The number (and %) of a zero Clustering coefficients1 (1.32 %)
The number (and %) of a zero Betweenness Centrality12 (15.79 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RPTOR All fusions
: AW500290;
Proteins found in more fusions TRAF6 (see 1 fusions); CUL4A (see 4 fusions); BAG3 (see 4 fusions); FKBP8 (see 1 fusions); ULK1 (see 2 fusions); MAPK1 (see 1 fusions); IKBKB (see 2 fusions); SQSTM1 (see 5 fusions); MTOR (see 1 fusions); SGK1 (see 2 fusions); DDB1 (see 2 fusions); RPTOR (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RPTORparental protein760.0953071.621HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
2 AKT1oncoprotein190.35959.143PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 AKT1S1interactor80.6193.105Pap_E4 (PF02711, IPR003861): E4 protein
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
4 AMBRA1interactor80.5717.519Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Spt20 (PF12090, IPR021950): Spt20 family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
5 BAG3oncoprotein110.33319.700BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
6 BRAT1oncoprotein30.6670.100HEAT (PF02985, IPR000357): HEAT repeat
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
7 CCNB1oncoprotein50.6001.800Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
8 CHUKsuppressor110.6446.084Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
9 CUL4Aprotein found in more fusions60.7001.733Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
10 CUL4Boncoprotein80.5008.919Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
11 DDB1protein found in more fusions120.41820.046CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
12 DEPTORinteractor80.6796.686DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PDZ_2 (PF13180, IPR001478): PDZ domain
Complex1_LYR_2 (PF13233): Complex1_LYR-like
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
13 EIF3Binteractor70.7621.519eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain
Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
14 EIF3Concoprotein60.8000.719eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
15 EIF4Eoncoprotein70.5715.219IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
16 EIF4EBP1oncoprotein60.5334.167eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
17 EIF4EBP2interactor40.6671.222eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
18 FAF2interactor50.5002.167DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
19 FKBP1Ainteractor40.6670.222FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
20 FKBP8protein found in more fusions60.8001.167FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
21 GDI2P1interactor31.0000NA
22 GNB1interactor80.5367.560Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
23 GNG2interactor41.0000G-gamma (PF00631, IPR015898, SM00224): GGL domain
SidE (PF12252, IPR021014): Dot/Icm substrate protein
24 GTF3C1interactor30.6670.100B-block_TFIIIC (PF04182, IPR007309): B-block binding subunit of TFIIIC
25 HIF1Asuppressor70.4768.300Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
26 HSPA4interactor170.37550.778Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
27 HTR6interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
28 ICKinteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
29 IKBKBprotein found in more fusions90.8211.657FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
30 IKBKGinteractor120.60010.879CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
31 IQGAP1interactor70.4297.571CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
32 IRS1interactor90.6396.767CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
33 IRS2oncoprotein60.5333.867CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
34 LAMTOR2interactor60.8671.000Robl_LC7 (PF03259, IPR004942, SM00960): Roadblock/LC7 domain
35 LARSinteractor50.5003.433Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
36 MAPK1oncoprotein110.35623.900Pkinase (PF00069, IPR000719): Protein kinase domain
37 MAPK3oncoprotein50.8330.500Pkinase (PF00069, IPR000719): Protein kinase domain
38 MAPK8oncoprotein70.9330.333DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
39 MARK4oncoprotein40.6670.900KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
40 MLST8interactor120.47020.352Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
41 MOV10interactor80.50010.600AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
42 MTMR3oncoprotein31.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
43 MTORoncoprotein550.1241021.552DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
44 NT5Einteractor21.00005_nucleotid_C (PF02872, IPR008334): 5'-nucleotidase, C-terminal domain
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
45 NTRK1oncoprotein270.160193.186I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
46 NXF1interactor130.40925.589NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
47 PARK2suppressor110.42215.067IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
48 PDIA3interactor50.6001.989Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
49 PDK1interactor50.8330.500HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
50 PLD2interactor50.7001.733PH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
51 PREX1oncoprotein41.0000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
52 PRKAA1suppressor70.5246.667Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
53 PRKAA2suppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
54 RAB1Aoncoprotein50.6002.556Ras (PF00071, IPR001806, SM00173): Ras family
55 RAP1Boncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
56 RHEBoncoprotein40.8330.500Ras (PF00071, IPR001806, SM00173): Ras family
57 RICTORinteractor200.31171.238RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain
RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
58 RPS6interactor90.5567.741Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
59 RPS6KA1oncoprotein50.6003.167Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
60 RPS6KB1interactor180.33852.824Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
61 RRAGAinteractor41.0000Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
DUF5099 (PF17025, IPR031503): Domain of unknown function (DUF5099)
62 RRAGBinteractor60.8671.000Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
63 RRAGCinteractor80.6795.833Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
64 RRAGDinteractor70.7144.000Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
65 SCAPinteractor30.6670.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
66 SGK1oncoprotein90.5716.219Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
67 SIRT1suppressor100.5569.986DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
68 SQSTM1oncoprotein210.33277.713PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
69 TIRAPinteractor31.0000TIR_2 (PF13676, IPR000157): TIR domain
70 TRAF6protein found in more fusions170.40046.624SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
71 TXNDC15interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
72 UCHL1suppressor60.6002.205Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
73 ULK1protein found in more fusions100.50012.533Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
74 USP9Xinteractor60.6002.989DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
75 XPO1interactor180.36655.279CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
76 YWHAQinteractor80.4299.62214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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