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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RPS6KA2 (from a repository: Thu Nov 17 14:39:42 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins6 (35.29 %)
The number (and %) of the tumor suppressors2 (11.76 %)
Total number of binary PPIs (saturation %)40 (29.41 %)
The number (and %) of affected PPIs17 (42.50 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.647
Assortativity coefficient-0.6198
The network average Clustering coefficient0.382
The number (and %) of a zero Clustering coefficients8 (47.06 %)
The number (and %) of a zero Betweenness Centrality10 (58.82 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RPS6KA2 All fusions
: BI011349;
Proteins found in more fusions FOS (see 4 fusions); CREBBP (see 5 fusions); RPS6KA2 (see 1 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RPS6KA2parental protein170.125196.567Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
2 CREBBPsuppressor70.8001.567Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
3 CSNK2Binteractor31.0000CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
4 ECE2interactor100Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
Peptidase_M48 (PF01435, IPR001915): Peptidase family M48
Methyltransf_25 (PF13649): Methyltransferase domain
5 FAT1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
DUF2808 (PF10989, IPR021256): Protein of unknown function (DUF2808)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Cadherin_3 (PF16184): Cadherin-like
6 FLNCinteractor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
7 FOSoncoprotein51.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
8 GRSF1interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
VWA_N2 (PF16164, IPR032361): VWA N-terminal
9 HSP90AA1oncoprotein40.6670.400HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
10 JUNoncoprotein70.6673.500bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
11 MAPK1oncoprotein70.8001.567Pkinase (PF00069, IPR000719): Protein kinase domain
12 MAPK3oncoprotein60.9000.400Pkinase (PF00069, IPR000719): Protein kinase domain
13 NQO2interactor200Flavodoxin_2 (PF02525, IPR003680): Flavodoxin-like fold
14 RPS6KA1oncoprotein60.5336.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
15 SHROOM3interactor100ASD1 (PF08688, IPR014800): Apx/Shroom domain ASD1
ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
ANAPC1 (PF12859, IPR024990): Anaphase-promoting complex subunit 1
16 STXBP2interactor100Sec1 (PF00995, IPR001619): Sec1 family
17 ZMYM5interactor100DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116)
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain

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