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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRPF8, RPL37A (from a repository: Sun Dec 4 15:30:00 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)274
The number (and %) of the onco-proteins79 (28.83 %)
The number (and %) of the tumor suppressors27 (9.85 %)
Total number of binary PPIs (saturation %)7768 (20.77 %)
The number (and %) of affected PPIs286 (3.68 %)
The number of possible different fusions55
PPI diameter3
PPI radius2
The average degree of PPI56.146
Assortativity coefficient0.0778
The network average Clustering coefficient0.528
The number (and %) of a zero Clustering coefficients4 (1.46 %)
The number (and %) of a zero Betweenness Centrality7 (2.55 %)


List of the fusions

PPI for parental proteins: PRPF8,RPL37A All fusions
: BG478185;
Proteins found in more fusions PRPF19 (see 2 fusions); CTPS2 (see 1 fusions); U2AF2 (see 2 fusions); RPL37A/PRPF8 (see 1 fusions); RANGAP1 (see 2 fusions); SART3 (see 2 fusions); PIP4K2B (see 3 fusions); HDAC5 (see 1 fusions); HNRNPU/RPL24 (see 1 fusions); RPLP2 (see 1 fusions); RPS24/RPS23 (see 1 fusions); RPL27/RPS6 (see 1 fusions); HUWE1 (see 2 fusions); RPL38/RPL3 (see 1 fusions); RPS19/RPS14 (see 1 fusions); NTRK1/RPL7A (see 1 fusions); PRKCD (see 2 fusions); CUL3 (see 1 fusions); NAP1L1 (see 3 fusions); MYC (see 1 fusions); AHCYL1 (see 3 fusions); KIF11 (see 1 fusions); COPS5 (see 1 fusions); UBC (see 1 fusions); TP53 (see 3 fusions); LUC7L2 (see 2 fusions); RACK1 (see 3 fusions); FN1/RPL6 (see 1 fusions); NTRK1/TPR (see 1 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); PRKDC (see 3 fusions); RPS5/RPL14 (see 1 fusions); RPL30/NOP58 (see 1 fusions); RPA1 (see 1 fusions); NEDD4 (see 1 fusions); PRPF3 (see 1 fusions); SUZ12 (see 2 fusions); SNW1 (see 1 fusions); ZMYND11 (see 1 fusions); APP (see 4 fusions); HSP90AA1 (see 2 fusions); SRPK2 (see 1 fusions); SNRNP200 (see 3 fusions); PRPF8 (see 3 fusions); TCF3 (see 4 fusions); PRPF6 (see 1 fusions); STAU1 (see 2 fusions); CUL7 (see 2 fusions); RACK1/FN1 (see 1 fusions); PRPF40A (see 2 fusions); PABPC1 (see 2 fusions); SERBP1 (see 1 fusions); MCM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PRPF8parental protein1530.1778171.635PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain
PROCN (PF08083, IPR012592): PROCN (NUC071) domain
PROCT (PF08084, IPR012984): PROCT (NUC072) domain
RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8
U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8
U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
2 RPL37Aparental protein1340.4223416.091Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
3 AAR2interactor80.5716.545AAR2 (PF05282, IPR007946): AAR2 protein
4 ABATinteractor21.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
5 ABCA1oncoprotein200.129ABC_tran (PF00005, IPR003439): ABC transporter
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
6 AHCYL1suppressor70.2007.911AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
7 APPprotein found in more fusions700.2361155.043APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8 ARoncoprotein130.3948.701Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
9 ASB15interactor30.3330.808Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
10 BCAS2interactor340.49046.359BCAS2 (PF05700, IPR008409): Breast carcinoma amplified sequence 2 (BCAS2)
ZapB (PF06005, IPR009252): Cell division protein ZapB
11 BSGinteractor100.46718.653Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
12 BUB3interactor200.31136.751WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
13 CAND1interactor1460.3811370.968Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
14 CCDC8interactor660.434194.738Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
15 CD2BP2interactor190.50360.343GYF (PF02213, IPR003169, SM00444): GYF domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
16 CDC40interactor160.60815.852AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
17 CDC5Linteractor930.320951.931OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion pr