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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RP11-72M17.1, CDC14A (from a repository: Sun Mar 15 00:54:46 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins4 (30.77 %)
The number (and %) of the tumor suppressors4 (30.77 %)
Total number of binary PPIs (saturation %)22 (28.21 %)
The number (and %) of affected PPIs11 (50.00 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.769
Assortativity coefficient-0.5418
The network average Clustering coefficient0.415
The number (and %) of a zero Clustering coefficients6 (46.15 %)
The number (and %) of a zero Betweenness Centrality10 (76.92 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CDC14A,RP11-72M17.1 All fusions
Proteins found in more fusions TP53 (see 3 fusions); POLR2A (see 2 fusions); NPM1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDC14Aparental protein110.12790.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pentaxin (PF00354, IPR001759, SM00159): Pentaxin family
PTPlike_phytase (PF14566): Inositol hexakisphosphate
DSPn (PF14671, IPR029260): Dual specificity protein phosphatase, N-terminal half
2 RP11-72M17.1interactor000NA
3 BRAPinteractor200BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
4 CCNB1oncoprotein31.0000Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
5 CDC25Boncoprotein100M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
6 CDC6oncoprotein31.0000Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
7 CHRM1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
8 FZR1suppressor50.6004.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
9 KIF20Ainteractor100Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
PhoU (PF01895, IPR026022): PhoU domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4359 (PF14271, IPR025578): Domain of unknown function (DUF4359)
10 NPM1suppressor31.0000Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
11 PLK1suppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
12 POLR2Aprotein found in more fusions200RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
13 TP53suppressor50.6672.000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif

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