Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RNF216 (from a repository: Fri Nov 11 22:43:20 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins7 (33.33 %)
The number (and %) of the tumor suppressors2 (9.52 %)
Total number of binary PPIs (saturation %)50 (23.81 %)
The number (and %) of affected PPIs21 (42.00 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI3.524
Assortativity coefficient-0.5520
The network average Clustering coefficient0.498
The number (and %) of a zero Clustering coefficients7 (33.33 %)
The number (and %) of a zero Betweenness Centrality13 (61.90 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RNF216 All fusions
Proteins found in more fusions RIPK1 (see 1 fusions); RNF11 (see 1 fusions); UBE2L6 (see 2 fusions); TICAM1 (see 1 fusions); RNF216 (see 1 fusions); UBE2H (see 4 fusions); UBE2C (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RNF216parental protein210.089322.667DUF226 (PF02890, IPR004180): Borrelia family of unknown function DUF226
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
DUF4645 (PF15488, IPR027891): Domain of unknown function (DUF4645)
2 ARCinteractor100DUF842 (PF05811, IPR008560): Eukaryotic protein of unknown function (DUF842)
Retrotrans_gag (PF03732, IPR005162): Retrotransposon gag protein
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
3 BECN1suppressor40.6671.000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
4 BRCA1suppressor40.6671.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
5 KIR2DL4interactor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
SVM_signal (PF12113, IPR021970): SVM protein signal sequence
6 MOV10interactor100AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
7 NXF1interactor31.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
8 RIPK1protein found in more fusions70.6005.333Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
9 RNF11protein found in more fusions31.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
10 TICAM1protein found in more fusions70.6673.667Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
TIR_2 (PF13676, IPR000157): TIR domain
11 TIRAPinteractor31.0000TIR_2 (PF13676, IPR000157): TIR domain
12 TLR3interactor41.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
13 TLR4interactor40.6672.000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
14 TLR5interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
15 TLR9interactor21.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
16 TRAF3oncoprotein70.6005.333ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
17 UBE2Concoprotein200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
18 UBE2Hprotein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
19 UBE2L3interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
20 UBE2L6protein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
21 XPO1interactor50.5005.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑