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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins14 (31.82 %)
The number (and %) of the tumor suppressors4 (9.09 %)
Total number of binary PPIs (saturation %)160 (16.91 %)
The number (and %) of affected PPIs44 (27.50 %)
The number of possible different fusions14
PPI diameter2
PPI radius1
The average degree of PPI6.045
Assortativity coefficient-0.3377
The network average Clustering coefficient0.463
The number (and %) of a zero Clustering coefficients8 (18.18 %)
The number (and %) of a zero Betweenness Centrality13 (29.55 %)


List of the fusions

PPI for parental proteins: RNF114 All fusions
: BP351618;
Proteins found in more fusions HSPB1 (see 4 fusions); UBE2D2 (see 2 fusions); TRAF6 (see 1 fusions); UBE2H (see 4 fusions); EWSR1 (see 2 fusions); UBE2E1 (see 2 fusions); UBC (see 1 fusions); TRAF4 (see 1 fusions); UBE2E2 (see 1 fusions); HSP90AA1 (see 2 fusions); MAP3K1 (see 1 fusions); SUZ12 (see 2 fusions); RNF114 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RNF114parental protein440.1001309.502zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
2 AK5interactor100ADK (PF00406, IPR000850): Adenylate kinase
Dpy-30 (PF05186, IPR007858): Dpy-30 motif
Zeta_toxin (PF06414, IPR010488): Zeta toxin
AAA_18 (PF13238): AAA domain
3 AUP1interactor21.0000CUE (PF02845, IPR003892, SM00546): CUE domain
4 BMI1oncoprotein60.6002.500zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
5 CDKN1Asuppressor30.6670.667CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
6 CPLX1interactor100Synaphin (PF05835, IPR008849): Synaphin protein
7 DSTNinteractor100Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
8 DTX3oncoprotein150.20056.697zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
9 EVI2Ainteractor100EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)
10 EWSR1oncoprotein60.7001.833RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
11 HSP90AA1oncoprotein70.4008.333HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
12 HSPB1oncoprotein50.6671.333HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
13 IDI2interactor100NUDIX (PF00293, IPR000086): NUDIX domain
14 LAGE3interactor21.0000Pcc1 (PF09341, IPR015419): Transcription factor Pcc1
15 MAP3K1oncoprotein100.27814.663zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
16 MAPK3oncoprotein40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
17 NUDCD2interactor21.0000CS (PF04969, IPR007052): CS domain
DUF3110 (PF11360, IPR021503): Protein of unknown function (DUF3110)
18 PARP11interactor200PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
WWE (PF02825, IPR004170, SM00678): WWE domain
19 RNF2interactor180.19982.863zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
20 RNF38interactor90.5714.561zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
21 RPSAinteractor60.4677.667Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
22 SUZ12suppressor50.6671.333DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
23 TNFAIP3suppressor60.7002.333OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
24 TRAF4oncoprotein60.4004.083MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
25 TRAF6protein found in more fusions120.36421.711SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
26 TRAIPinteractor90.4298.597Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
ORF6C (PF10552, IPR018878): ORF6C domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
27 TRIM52interactor100BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
28 TRIM55interactor50.6670.444Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
NABP (PF07990, IPR012940): Nucleic acid binding protein NABP
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
29 UBCprotein found in more fusions140.35936.635ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
30 UBE2D1interactor130.39423.639UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
31 UBE2D2oncoprotein120.50910.758UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
32 UBE2D3interactor110.33314.472UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
33 UBE2D4interactor70.4002.570UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
34 UBE2DNLinteractor21.0000NA
35 UBE2E1protein found in more fusions60.4001.551UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
36 UBE2E2protein found in more fusions40.6670.182UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
37 UBE2E3interactor50.6670.432UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
38 UBE2Hprotein found in more fusions60.5001.487UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
39 UBE2Kinteractor70.5712.684UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
40 UBE2Uinteractor30.6670.286UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
efb-c (PF12199, IPR021033): Extracellular fibrinogen binding protein C terminal
TMEM154 (PF15102, IPR028064): TMEM154 protein family
41 UBE2Winteractor50.5000.682UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
42 UEVLDinteractor40.6670.500Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
UEV (PF05743, IPR008883): UEV domain
43 USO1interactor31.0000Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Uso1_p115_head (PF04869, IPR006953): Uso1 / p115 like vesicle tethering protein, head region
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
MG1 (PF11974, IPR021868): Alpha-2-macroglobulin MG1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
44 XAF1suppressor100Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
PL48 (PF15903, IPR031780): Filopodia upregulated, FAM65

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