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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins16 (29.63 %)
The number (and %) of the tumor suppressors8 (14.81 %)
Total number of binary PPIs (saturation %)224 (15.65 %)
The number (and %) of affected PPIs54 (24.11 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI6.852
Assortativity coefficient-0.3367
The network average Clustering coefficient0.588
The number (and %) of a zero Clustering coefficients4 (7.41 %)
The number (and %) of a zero Betweenness Centrality15 (27.78 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RNF111 All fusions
: BP221100;
Proteins found in more fusions CSNK2A1 (see 1 fusions); CTBP1 (see 2 fusions); UBE2D2 (see 2 fusions); RNF111 (see 1 fusions); UBE2E1 (see 2 fusions); UBC (see 1 fusions); UBE2E2 (see 1 fusions); PML (see 4 fusions); SMURF2 (see 1 fusions); CREB1 (see 2 fusions); HSP90AA1 (see 2 fusions); DTX3L (see 2 fusions); UBE2N (see 1 fusions); SKI (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RNF111parental protein540.0961956.901zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
2 ACTN3interactor200CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
IncA (PF04156, IPR007285): IncA protein
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
3 ANAPC11interactor60.9000.286zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
4 AXIN2suppressor31.0000Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
THP2 (PF09432, IPR018557): Tho complex subunit THP2
DIX (PF00778, IPR001158, SM00021): DIX domain
AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
5 CREB1oncoprotein40.6671.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
6 CSNK2A1oncoprotein70.5335.233Pkinase (PF00069, IPR000719): Protein kinase domain
7 CSNK2A2interactor50.7002.167Pkinase (PF00069, IPR000719): Protein kinase domain
8 CTBP1protein found in more fusions40.6670.6672-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
9 DTX3Lprotein found in more fusions130.25836.957KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
10 EDARADDinteractor41.0000Death (PF00531, IPR000488, SM00005): Death domain
SCO1-SenC (PF02630, IPR003782): SCO1/SenC
11 ESRP1suppressor100RNase_T (PF00929, IPR013520): Exonuclease
T2SSE_N (PF05157, IPR007831): Type II secretion system (T2SS), protein E, N-terminal domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 ESRP2interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
13 FHL2oncoprotein60.5004.333LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
14 HSP90AA1oncoprotein60.6003.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
15 KRTAP5-9interactor21.0000Ery_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
16 LCE4Ainteractor21.0000LCE (PF14672, IPR028205): Late cornified envelope
17 LRSAM1interactor120.25526.224Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
18 MARCH7interactor100.47211.057RINGv (PF12906, IPR011016, SM00744): RING-variant domain
19 MVPoncoprotein41.0000Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
20 NR4A1suppressor50.7002.167zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
21 PHF7interactor31.0000zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
22 PMLsuppressor120.40026.133zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
23 RB1CC1suppressor40.6671.667Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
24 SKIoncoprotein90.6076.800c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
25 SKILsuppressor100.5839.267c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
26 SMAD2suppressor100.5839.800MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
27 SMAD3oncoprotein100.5839.133MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
28 SMAD6interactor50.7002.667MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
29 SMAD7interactor70.6196.333MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
30 SMURF2protein found in more fusions120.41824.660C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
31 SUMO1interactor60.6002.289Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
32 SUMO2interactor50.6670.622Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
33 SUMO3interactor40.6670.622Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
34 TRAF5interactor31.0000Sina (PF03145, IPR018121): Seven in absentia protein family
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
35 TRIM21interactor70.7331.622DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
36 TRIM8interactor100.33317.405dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
37 TSG101suppressor50.5000.908APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
38 UBCprotein found in more fusions230.186161.524ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
39 UBE2D1interactor110.4899.921UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
40 UBE2D2oncoprotein150.42929.129UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
41 UBE2D3interactor90.3578.788UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
42 UBE2D4interactor60.5002.917UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
43 UBE2E1protein found in more fusions60.5001.769UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
44 UBE2E2protein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
45 UBE2E3interactor40.6670.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
46 UBE2G2interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
47 UBE2Iinteractor180.22189.400UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
48 UBE2Kinteractor100.53310.410UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
49 UBE2Minteractor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
50 UBE2Nprotein found in more fusions80.6194.638UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
51 UBE2Q2interactor200Josephin (PF02099, IPR006155): Josephin
RWD (PF05773, IPR006575, SM00591): RWD domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
DUF2890 (PF11081, IPR021304): Protein of unknown function (DUF2890)
52 UBE2V1interactor60.7332.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
53 UBE2Winteractor50.5000.917UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
54 XPConcoprotein31.0000Rad4 (PF03835, IPR018325): Rad4 transglutaminase-like domain
BHD_1 (PF10403, IPR018326, SM01030): Rad4 beta-hairpin domain 1
BHD_2 (PF10404, IPR018327, SM01031): Rad4 beta-hairpin domain 2
BHD_3 (PF10405, IPR018328, SM01032): Rad4 beta-hairpin domain 3
Macoilin (PF09726, IPR019130): Transmembrane protein
SOG2 (PF10428, IPR019487): RAM signalling pathway protein
Abdominal-A (PF12407, IPR022132): Homeobox protein
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)

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