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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins9 (37.50 %)
The number (and %) of the tumor suppressors6 (25.00 %)
Total number of binary PPIs (saturation %)58 (21.01 %)
The number (and %) of affected PPIs24 (41.38 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI3.667
Assortativity coefficient-0.4292
The network average Clustering coefficient0.542
The number (and %) of a zero Clustering coefficients7 (29.17 %)
The number (and %) of a zero Betweenness Centrality15 (62.50 %)


List of the fusions

PPI for parental proteins: RHOBTB3 All fusions
: BF986091;
Proteins found in more fusions EGLN1 (see 1 fusions); CUL3 (see 1 fusions); VHL (see 1 fusions); RHOBTB3 (see 1 fusions); HSP90AA1 (see 2 fusions); RBPMS (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RHOBTB3parental protein240.083429.500BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
2 BHLHE40interactor31.0000Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
3 CCNB1oncoprotein100Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
4 CCNE1oncoprotein21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
5 CUL3protein found in more fusions80.38112.167Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
6 EGLN1suppressor50.8330.667zf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
7 FASsuppressor200Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
8 HGSinteractor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
9 HIF1Asuppressor50.7001.833Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
10 HSP90AA1oncoprotein70.5336.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
11 HTR7interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
12 ISLRinteractor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
13 KIR2DS2interactor200ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
14 LIMD1suppressor41.0000LIM (PF00412, IPR001781, SM00132): LIM domain
15 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
16 NTRK1oncoprotein50.6672.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 PLIN3interactor31.0000Perilipin (PF03036, IPR004279): Perilipin family
18 RAB9Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
19 RABGGTBoncoprotein100Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
20 RBPMSprotein found in more fusions40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 RBX1oncoprotein50.6671.333zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
22 RHOBTB2suppressor41.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
23 UBXN11interactor100DivIC (PF04977, IPR007060): Septum formation initiator
SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
24 VHLsuppressor80.4769.500Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain

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