Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RHOBTB3 (from a repository: Sat Nov 12 09:37:04 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins9 (37.50 %)
The number (and %) of the tumor suppressors6 (25.00 %)
Total number of binary PPIs (saturation %)58 (21.01 %)
The number (and %) of affected PPIs24 (41.38 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI3.667
Assortativity coefficient-0.4292
The network average Clustering coefficient0.542
The number (and %) of a zero Clustering coefficients7 (29.17 %)
The number (and %) of a zero Betweenness Centrality15 (62.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RHOBTB3 All fusions
: BF986091;
Proteins found in more fusions EGLN1 (see 1 fusions); CUL3 (see 1 fusions); VHL (see 1 fusions); RHOBTB3 (see 1 fusions); HSP90AA1 (see 2 fusions); RBPMS (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RHOBTB3parental protein240.083429.500BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
2 BHLHE40interactor31.0000Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
3 CCNB1oncoprotein100Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
4 CCNE1oncoprotein21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
5 CUL3protein found in more fusions80.38112.167Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
6 EGLN1suppressor50.8330.667zf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
7 FASsuppressor200Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
8 HGSinteractor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
9 HIF1Asuppressor50.7001.833Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
10 HSP90AA1oncoprotein70.5336.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
11 HTR7interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
12 ISLRinteractor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
13 KIR2DS2interactor200ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
14 LIMD1suppressor41.0000LIM (PF00412, IPR001781, SM00132): LIM domain
15 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
16 NTRK1oncoprotein50.6672.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 PLIN3interactor31.0000Perilipin (PF03036, IPR004279): Perilipin family
18 RAB9Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
19 RABGGTBoncoprotein100Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
20 RBPMSprotein found in more fusions40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 RBX1oncoprotein50.6671.333zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
22 RHOBTB2suppressor41.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
23 UBXN11interactor100DivIC (PF04977, IPR007060): Septum formation initiator
SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
24 VHLsuppressor80.4769.500Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain

B a c k    t o    T o p ⇑