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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SFTPC, RGMA (from a repository: Thu Dec 8 12:18:23 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins5 (16.67 %)
The number (and %) of the tumor suppressors3 (10.00 %)
Total number of binary PPIs (saturation %)50 (11.49 %)
The number (and %) of affected PPIs29 (58.00 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI2.600
Assortativity coefficient-0.3365
The network average Clustering coefficient0.252
The number (and %) of a zero Clustering coefficients20 (66.67 %)
The number (and %) of a zero Betweenness Centrality22 (73.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: RGMA,SFTPC All fusions
: AI336345;
Proteins found in more fusions VCP (see 4 fusions); NEDD4 (see 1 fusions); TERF2IP (see 1 fusions); SFTPC (see 1 fusions); TXNIP (see 2 fusions); WWP1 (see 1 fusions); HIPK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RGMAparental protein140541.000RGM_C (PF06534, IPR009496): Repulsive guidance molecule (RGM) C-terminus
RGM_N (PF06535, IPR010536): Repulsive guidance molecule (RGM) N-terminus
2 SFTPCparental protein150.099427.667BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
3 ANO3interactor20195.000Anoctamin (PF04547, IPR007632): Calcium-activated chloride channel
Anoct_dimer (PF16178, IPR032394): Dimerisation domain of Ca+-activated chloride-channel, anoctamin
4 BDP1interactor100SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
DUF2917 (PF11142, IPR021317): Protein of unknown function (DUF2917)
UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542
Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
5 CLK4interactor100Mu-conotoxin (PF05374, IPR008036): Mu-Conotoxin
Pkinase (PF00069, IPR000719): Protein kinase domain
6 CXCL9interactor21.0000MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
SNARE (PF05739, IPR000727, SM00397): SNARE domain
VasL (PF12486, IPR021069): Type VI secretion system, EvfB, or VasL
7 DNAJB9interactor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
8 DNAJC10interactor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
9 HIPK2suppressor200Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
10 HSPA5oncoprotein80.286424.667HSP70 (PF00012, IPR013126): Hsp70 protein
11 NBEAL1interactor100Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
DUF4800 (PF16057): Domain of unknown function (DUF4800)
12 NCOR2oncoprotein20195.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
13 NEDD4suppressor200Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
14 PPHLN1interactor100Lge1 (PF11488): Transcriptional regulatory protein LGE1
HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
15 PPP1R16Ainteractor200Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
16 PQBP1interactor100WW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
17 SAMD4Binteractor100PHAT (PF09246, IPR015327): PHAT
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
18 SEC22Ainteractor30.6671.000Longin (PF13774, IPR010908): Regulated-SNARE-like domain
19 SEC61Ginteractor100SecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complex
20 SGSM2interactor100Cullin_binding (PF03556, IPR005176): Cullin binding
RUN (PF02759, IPR004012, SM00593): RUN domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
21 SPICE1interactor100SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression
ANXA2R (PF15721, IPR031449): Annexin-2 receptor
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
22 SYNE4interactor30.6671.000KASH (PF10541, IPR012315): Nuclear envelope localisation domain
23 TCEB2interactor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
24 TERF2IPprotein found in more fusions200BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
25 TMEM67interactor21.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
26 TMEM79interactor31.0000MAPEG (PF01124, IPR001129): MAPEG family
27 TXNIPsuppressor200Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
28 VCPprotein found in more fusions50.8330.667AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
29 WWP1oncoprotein200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
30 WWP2interactor200WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CXCL9interactorMRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
SNARE (PF05739, IPR000727, SM00397): SNARE domain
VasL (PF12486, IPR021069): Type VI secretion system, EvfB, or VasL
AI336345
2 DNAJB9interactorDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
AI336345
3 DNAJC10interactorDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
AI336345
4 HSPA5oncoproteinHSP70 (PF00012, IPR013126): Hsp70 proteinAI336345
5 NEDD4suppressorRota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
AI336345
6 PQBP1interactorWW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
AI336345
7 RGMAparental proteinRGM_C (PF06534, IPR009496): Repulsive guidance molecule (RGM) C-terminus
RGM_N (PF06535, IPR010536): Repulsive guidance molecule (RGM) N-terminus
AI336345
8 SEC22AinteractorLongin (PF13774, IPR010908): Regulated-SNARE-like domainAI336345
9 SEC61GinteractorSecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complexAI336345
10 SFTPCparental proteinBRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
AI336345
11 SYNE4interactorKASH (PF10541, IPR012315): Nuclear envelope localisation domainAI336345
12 TMEM67interactorEphrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
AI336345
13 TMEM79interactorMAPEG (PF01124, IPR001129): MAPEG familyAI336345
14 VCPinteractorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
AI336345
15 WWP1oncoproteinC2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
AI336345
16 WWP2interactorWW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
AI336345

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