Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RFFL (from a repository: Thu Nov 10 14:59:26 2016)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins7 (29.17 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)61 (22.10 %)
The number (and %) of affected PPIs24 (39.34 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI4.000
Assortativity coefficient-0.6613
The network average Clustering coefficient0.512
The number (and %) of a zero Clustering coefficients6 (25.00 %)
The number (and %) of a zero Betweenness Centrality12 (50.00 %)


List of the fusions

PPI for parental proteins: RFFL All fusions
Proteins found in more fusions RIPK1 (see 1 fusions); RFFL (see 1 fusions); TP53 (see 3 fusions); UBE2D2 (see 2 fusions); SHC1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RFFLparental protein240.099398.167FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Armet (PF10208, IPR019345): Degradation arginine-rich protein for mis-folding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
2 ATXN3interactor31.0000Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
3 ATXN3Linteractor21.0000Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
4 EFCAB7interactor100EF_assoc_2 (PF08356, IPR013567): EF hand associated
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
5 ESPL1interactor21.0000Peptidase_C50 (PF03568, IPR005314): Peptidase family C50
6 IQCEinteractor100CaMBD (PF02888, IPR004178, SM01053): Calmodulin binding domain
CHD5 (PF04420, IPR028945): CHD5-like protein
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
SOGA (PF11365, IPR027881): Protein SOGA
7 MDM2oncoprotein80.4298.667Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
8 NEFHinteractor100DUF1388 (PF07142, IPR010790): Repeat of unknown function (DUF1388)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Filament (PF00038, IPR001664): Intermediate filament protein
9 OTUB1interactor70.33310.000Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
10 OTUB2interactor30.6671.000Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
11 PRKD2interactor100ABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
12 RIPK1protein found in more fusions200Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
13 RNF34interactor30.6670.500Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
14 SHC1oncoprotein200PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
15 STAMinteractor21.0000GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16 TP53oncoprotein60.5003.167DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
17 UBE2D1interactor50.8330.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
18 UBE2D2oncoprotein60.6002.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
19 UBE2D3interactor50.6670.833UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
20 UBE2G2interactor40.6670.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
21 UCHL5oncoprotein31.0000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
22 USP28interactor100.22227.500TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UBA_4 (PF14555): UBA-like domain
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
23 USP5interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
24 USP7oncoprotein60.6002.833MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal

B a c k    t o    T o p ⇑