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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RFFL (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins7 (29.17 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)61 (22.10 %)
The number (and %) of affected PPIs24 (39.34 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI4.000
Assortativity coefficient-0.6613
The network average Clustering coefficient0.512
The number (and %) of a zero Clustering coefficients6 (25.00 %)
The number (and %) of a zero Betweenness Centrality12 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RFFL All fusions
Proteins found in more fusions RIPK1 (see 1 fusions); RFFL (see 1 fusions); TP53 (see 3 fusions); UBE2D2 (see 2 fusions); SHC1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RFFLparental protein240.099398.167FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Armet (PF10208, IPR019345): Degradation arginine-rich protein for mis-folding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
2 ATXN3interactor31.0000Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
3 ATXN3Linteractor21.0000Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
4 EFCAB7interactor100EF_assoc_2 (PF08356, IPR013567): EF hand associated
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
5 ESPL1interactor21.0000Peptidase_C50 (PF03568, IPR005314): Peptidase family C50
6 IQCEinteractor100CaMBD (PF02888, IPR004178, SM01053): Calmodulin binding domain
CHD5 (PF04420, IPR028945): CHD5-like protein
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
SOGA (PF11365, IPR027881): Protein SOGA
7 MDM2oncoprotein80.4298.667Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
8 NEFHinteractor100DUF1388 (PF07142, IPR010790): Repeat of unknown function (DUF1388)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Filament (PF00038, IPR001664): Intermediate filament protein
9 OTUB1interactor70.33310.000Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
10 OTUB2interactor30.6671.000Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
11 PRKD2interactor100ABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
12 RIPK1protein found in more fusions200Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
13 RNF34interactor30.6670.500Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
14 SHC1oncoprotein200PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
15 STAMinteractor21.0000GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16 TP53oncoprotein60.5003.167DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
17 UBE2D1interactor50.8330.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
18 UBE2D2oncoprotein60.6002.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
19 UBE2D3interactor50.6670.833UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
20 UBE2G2interactor40.6670.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
21 UCHL5oncoprotein31.0000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
22 USP28interactor100.22227.500TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UBA_4 (PF14555): UBA-like domain
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
23 USP5interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
24 USP7oncoprotein60.6002.833MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal

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