Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins REV1 (from a repository: Mon Dec 5 00:31:21 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins10 (41.67 %)
The number (and %) of the tumor suppressors3 (12.50 %)
Total number of binary PPIs (saturation %)93 (33.70 %)
The number (and %) of affected PPIs24 (25.81 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI6.583
Assortativity coefficient-0.2238
The network average Clustering coefficient0.665
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality3 (12.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: REV1 All fusions
: BU675470;
Proteins found in more fusions MSH2 (see 1 fusions); REV1 (see 1 fusions); HSP90AA1 (see 2 fusions); HSP90AB1 (see 1 fusions); MYC (see 1 fusions); PCNA (see 1 fusions); TP53 (see 3 fusions); UBC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 REV1parental protein240.221256.586IMS (PF00817, IPR001126): impB/mucB/samB family
Cdd1 (PF11731, IPR021725): Pathogenicity locus
IMS_HHH (PF11798, IPR024728): IMS family HHH motif
IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
REV1_C (PF16727, IPR031991): DNA repair protein REV1 C-terminal domain
2 BRCA1suppressor130.51518.419BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
3 CDC27oncoprotein40.6670.500TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
4 CLK1interactor31.0000PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
5 FAAP20interactor30.6670.667UBZ_FAAP20 (PF15750, IPR031490): Ubiquitin-binding zinc-finger
FANCA_interact (PF15751, IPR031491): FAAP20 FANCA interaction domain
6 FANCD2oncoprotein80.6435.519FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
7 FANCIinteractor40.6671.667DUF3972 (PF13118, IPR025002): Protein of unknown function (DUF3972)
FANCI_S1-cap (PF14674, IPR029305): FANCI solenoid 1 cap
FANCI_S1 (PF14675, IPR029308): FANCI solenoid 1
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3
FANCI_S4 (PF14678, IPR029314): FANCI solenoid 4
FANCI_HD1 (PF14679, IPR029310): FANCI helical domain 1
FANCI_HD2 (PF14680, IPR029312): FANCI helical domain 2
8 FHL2oncoprotein50.8330.286LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
9 HSP90AA1oncoprotein70.7332.167HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
10 HSP90AB1oncoprotein50.8330.400HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
11 MAD2L2interactor60.4004.833HORMA (PF02301, IPR003511): HORMA domain
12 MSH2suppressor80.7143.667MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
13 MYConcoprotein110.51113.400HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
14 PCNAoncoprotein120.38227.233PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
15 PIAS4interactor40.6672.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
16 POLD3interactor40.6671.167CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
17 POLDIP2interactor40.6671.167DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525)
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
18 POLHoncoprotein80.6435.352IMS (PF00817, IPR001126): impB/mucB/samB family
IMS_HHH (PF11798, IPR024728): IMS family HHH motif
IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
19 POLIinteractor40.8330.333IMS (PF00817, IPR001126): impB/mucB/samB family
Cdd1 (PF11731, IPR021725): Pathogenicity locus
IMS_HHH (PF11798, IPR024728): IMS family HHH motif
IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
20 POLKinteractor31.0000ATP-cone (PF03477, IPR005144): ATP cone domain
IMS (PF00817, IPR001126): impB/mucB/samB family
IMS_HHH (PF11798, IPR024728): IMS family HHH motif
IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
21 RELAoncoprotein60.9000.286DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
22 REV3Linteractor21.0000DNA_pol_B (PF00136, IPR006134): DNA polymerase family B
DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
DUF4683 (PF15735, IPR032757): Domain of unknown function (DUF4683)
23 TP53suppressor130.40928.519DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
24 UBCprotein found in more fusions110.40019.833ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

B a c k    t o    T o p ⇑