Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins REPS1 (from a repository: Thu Nov 17 13:46:35 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 21 The number (and %) of the onco-proteins 8 (38.10 %) The number (and %) of the tumor suppressors 2 (9.52 %) Total number of binary PPIs (saturation %) 51 (24.29 %) The number (and %) of affected PPIs 21 (41.18 %) The number of possible different fusions 5 PPI diameter 2 PPI radius 1 The average degree of PPI 3.810 Assortativity coefficient -0.5272 The network average Clustering coefficient 0.434 The number (and %) of a zero Clustering coefficients 8 (38.10 %) The number (and %) of a zero Betweenness Centrality 11 (52.38 %)

ACTIVE INTERACTORS MISSING INTERACTORS (in fusions)

List of the fusions
PPI for parental proteins: REPS1	All fusions : BU674501;
Proteins found in more fusions	ITSN2 (see 1 fusions); AP2M1 (see 3 fusions); REPS1 (see 1 fusions); RAB11FIP2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	REPS1	parental protein	21	0.105	306.667	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator MCLC (PF05934, IPR009231): Mid-1-related chloride channel (MCLC) DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
2	ABL1	oncoprotein	4	0.667	0.667	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	AMPH	oncoprotein	5	0.700	1.833	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
4	AP2M1	protein found in more fusions	9	0.429	14.167	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
5	ATF4	oncoprotein	2	0	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
6	CFTR	suppressor	2	0	0	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
7	CLTC	oncoprotein	6	0.533	5.833	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link
8	GTSE1	interactor	4	0.833	0.667	GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
9	ITSN1	interactor	8	0.524	8.333	C2 (PF00168, IPR000008, SM00239): C2 domain VIT1 (PF01988, IPR008217): VIT family DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region PH_13 (PF16652, IPR001849): Pleckstrin homology domain
10	ITSN2	protein found in more fusions	5	0.833	0.500	C2 (PF00168, IPR000008, SM00239): C2 domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) SH3_9 (PF14604, IPR001452): Variant SH3 domain MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26 VIR_N (PF15912, IPR031801): Virilizer, N-terminal PH_13 (PF16652, IPR001849): Pleckstrin homology domain
11	LIMS1	interactor	1	0	0	LIM (PF00412, IPR001781, SM00132): LIM domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
12	LRFN4	interactor	1	0	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
13	NTRK1	oncoprotein	4	0.667	0.667	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
14	PIN1	suppressor	1	0	0	Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain
15	RAB11FIP2	protein found in more fusions	3	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain RBD-FIP (PF09457, IPR019018): FIP domain
16	RALBP1	interactor	4	0.833	0.667	DDHD (PF02862, IPR004177, SM01127): DDHD domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SlyX (PF04102, IPR007236): SlyX Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2 DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505) Nod1 (PF17114, IPR032634): Gef2-related medial cortical node protein Nod1
17	SGF29	interactor	1	0	0	DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain Filament (PF00038, IPR001664): Intermediate filament protein
18	SGIP1	interactor	3	1.000	0	muHD (PF10291, IPR018808): Muniscin C-terminal mu homology domain
19	SLC25A41	interactor	3	1.000	0	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
20	TRAPPC2L	interactor	2	0	0	Sedlin_N (PF04628, IPR006722): Sedlin, N-terminal conserved region
21	WWC2	interactor	2	0	0	DASH_Dad2 (PF08654, IPR013963): DASH complex subunit Dad2 DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) Phage_Nu1 (PF07471, IPR010906): Phage DNA packaging protein Nu1 WW (PF00397, IPR001202, SM00456): WW domain

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List of missing interactors (in fusions)

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	REPS1	parental protein	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator MCLC (PF05934, IPR009231): Mid-1-related chloride channel (MCLC) DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand	BU674501

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