Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins REG1A, GNA11 (from a repository: Thu May 18 01:00:04 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins5 (15.15 %)
The number (and %) of the tumor suppressors5 (15.15 %)
Total number of binary PPIs (saturation %)65 (12.31 %)
The number (and %) of affected PPIs31 (47.69 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.273
Assortativity coefficient-0.3712
The network average Clustering coefficient0.418
The number (and %) of a zero Clustering coefficients14 (42.42 %)
The number (and %) of a zero Betweenness Centrality19 (57.58 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: REG1A,GNA11 All fusions
: BM126025; CK818890; CK818891; BM126302;
Proteins found in more fusions PLCB1 (see 1 fusions); GNAS (see 5 fusions); APP (see 4 fusions); SLC9A3R1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 REG1Aparental protein3066.000Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
2 GNA11parental protein280.050837.300G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
3 ABCE1interactor40.6670.500ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 APPprotein found in more fusions5077.600APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATMsuppressor31.0000FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
6 CCNL2interactor21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
7 CFTRsuppressor31.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
8 CXCR5interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
9 EDNRAinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
10 EDNRBsuppressor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
11 ELAVL1oncoprotein80.238105.400RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 FBXL18interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
13 FYTTD1interactor200FYTT (PF07078, IPR009782): Forty-two-three protein
14 GNASoncoprotein60.5004.500G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
15 GNB1interactor60.40015.200Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
16 GNB2interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
17 GNB4interactor70.28614.000Spore_YhcN_YlaJ (PF09580, IPR019076): Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
18 HOXB5interactor21.0000DUF739 (PF05339, IPR008003): Protein of unknown function (DUF739)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
19 MFSD13Ainteractor30.33340.200MFS_2 (PF13347): MFS/sugar transport protein
20 MTNR1Ainteractor30.6670.5007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
21 NUFIP1interactor100NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
22 PAPOLAinteractor21.0000PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
23 PLCB1oncoprotein31.0000DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
zf-C2H2_assoc (PF16606): Unstructured conserved, between two C2H2-type zinc-fingers
24 REG1Binteractor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
25 RFWD2suppressor3043.400Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
26 RGS13interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
27 RGS14interactor2036.200GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
RGS12_us1 (PF16613): Unstructured region of RGS12
28 RGS3oncoprotein2036.200C2 (PF00168, IPR000008, SM00239): C2 domain
CDC45 (PF02724, IPR003874): CDC45-like protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein
29 SLC25A41interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
30 SLC9A3R1suppressor40.6671.000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
31 TBXA2Rinteractor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
32 TMEM185Ainteractor21.0000Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
33 TMEM63Binteractor21.0000RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter

B a c k    t o    T o p ⇑


List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 GNA11parental proteinG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunitBM126025, BM126302, CK818890, CK818891
2 GNASoncoproteinG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunitBM126025, BM126302, CK818890, CK818891
3 REG1Aparental proteinLectin_C (PF00059, IPR001304, SM00034): Lectin C-type domainBM126025, BM126302, CK818890, CK818891
4 REG1BinteractorLectin_C (PF00059, IPR001304, SM00034): Lectin C-type domainBM126302, CK818890, CK818891

B a c k    t o    T o p ⇑