Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins RCOR1 (from a repository: Sun Nov 13 16:19:32 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 52 The number (and %) of the onco-proteins 16 (30.77 %) The number (and %) of the tumor suppressors 8 (15.38 %) Total number of binary PPIs (saturation %) 229 (17.27 %) The number (and %) of affected PPIs 52 (22.71 %) The number of possible different fusions 8 PPI diameter 2 PPI radius 1 The average degree of PPI 8.115 Assortativity coefficient -0.3668 The network average Clustering coefficient 0.705 The number (and %) of a zero Clustering coefficients 2 (3.85 %) The number (and %) of a zero Betweenness Centrality 13 (25.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: RCOR1	All fusions
Proteins found in more fusions	KDM1A (see 2 fusions); CTBP1 (see 2 fusions); RCOR1 (see 2 fusions); CTBP2 (see 2 fusions); HMG20A (see 1 fusions); TCF3 (see 3 fusions); NPM1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	RCOR1	parental protein	52	0.125	1397.490	DivIC (PF04977, IPR007060): Septum formation initiator ELM2 (PF01448, IPR000949): ELM2 domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain FAM76 (PF16046, IPR032017): FAM76 protein
2	ARRDC1	interactor	3	1.000	0	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
3	B9D2	interactor	2	1.000	0	B9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 protein
4	BCL3	oncoprotein	7	0.667	2.868	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
5	CEP135	interactor	1	0	0	DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family LPP (PF04728, IPR006817): Lipoprotein leucine-zipper RasGAP_C (PF03836, IPR000593): RasGAP C-terminus Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein TPD52 (PF04201, IPR007327): Tumour protein D52 family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
6	CTBP1	protein found in more fusions	12	0.545	14.637	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
7	CTBP2	protein found in more fusions	8	0.667	3.400	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
8	DDX46	interactor	1	0	0	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) CdAMP_rec (PF06153, IPR010375): Cyclic-di-AMP receptor DDRGK (PF09756, IPR019153, SM01128): DDRGK domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FAM176 (PF14851): FAM176 family
9	DOK4	interactor	3	1.000	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
10	ECE2	interactor	2	1.000	0	Peptidase_M13 (PF01431, IPR018497): Peptidase family M13 Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13 Peptidase_M48 (PF01435, IPR001915): Peptidase family M48 Methyltransf_25 (PF13649): Methyltransferase domain
11	EMD	interactor	5	0.667	0.848	LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
12	ESCO2	interactor	5	1.000	0	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO Acetyltransf_13 (PF13880, IPR028009): ESCO1/2 acetyl-transferase
13	FBXW7	suppressor	6	0.700	3.000	Mem_trans (PF03547, IPR004776): Membrane transport protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 F-box-like (PF12937, IPR001810): F-box-like
14	FGF1	oncoprotein	4	1.000	0	FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
15	GFI1	oncoprotein	4	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
16	GFI1B	oncoprotein	3	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
17	HDAC1	suppressor	30	0.259	180.919	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
18	HDAC2	suppressor	31	0.248	205.519	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
19	HDAC3	suppressor	13	0.333	26.652	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
20	HIST1H3A	interactor	11	0.556	11.971	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
21	HIST3H3	interactor	8	0.714	3.967	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
22	HMG20A	protein found in more fusions	11	0.644	9.667	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812) MlaC (PF05494, IPR008869): MlaC protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
23	HMG20B	interactor	8	0.893	1.000	IncA (PF04156, IPR007285): IncA protein NEMP (PF10225, IPR019358): NEMP family HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
24	HSPA4	interactor	8	0.500	7.404	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
25	KDM1A	protein found in more fusions	32	0.204	279.971	Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain SWIRM (PF04433, IPR007526): SWIRM domain DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
26	KDM5B	interactor	7	0.810	1.900	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase JmjN (PF02375, IPR003349, SM00545): jmjN domain PHD (PF00628, IPR019787, SM00249): PHD-finger PLU-1 (PF08429, IPR013637): PLU-1-like protein FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger Rubredoxin (PF00301, IPR024935): Rubredoxin zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger Lipoprotein_20 (PF13942, IPR025262): YfhG lipoprotein
27	MECP2	interactor	4	0.833	0.400	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
28	MED12	oncoprotein	6	0.733	2.500	Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12 Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877) Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
29	MED23	interactor	9	0.444	17.833	Med23 (PF11573, IPR021629): Mediator complex subunit 23
30	MED28	interactor	6	0.900	0.500	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain Med28 (PF11594, IPR021640): Mediator complex subunit 28
31	MTA3	oncoprotein	7	0.905	0.800	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
32	NINL	interactor	2	1.000	0	PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat TBCA (PF02970, IPR004226): Tubulin binding cofactor A DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389) Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein FAM184 (PF15665): Family with sequence similarity 184, A and B TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
33	NPM1	suppressor	8	0.762	2.300	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
34	NR2C1	interactor	6	0.800	0.737	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
35	NR2E1	interactor	6	0.800	0.904	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
36	OBFC1	interactor	3	1.000	0	STN1_2 (PF09170, IPR015253): CST, Suppressor of cdc thirteen homolog, complex subunit STN1 RUN (PF02759, IPR004012, SM00593): RUN domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain Stn1 (PF10451, IPR018856): Telomere regulation protein Stn1
37	PHF21A	interactor	9	0.667	6.633	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DDHD (PF02862, IPR004177, SM01127): DDHD domain DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Peroxidase_2 (PF01328, IPR000028): Peroxidase, family 2 PHD (PF00628, IPR019787, SM00249): PHD-finger STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
38	REST	oncoprotein	8	0.607	11.000	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) Presenilin (PF01080, IPR001108): Presenilin RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
39	SCLT1	oncoprotein	4	0.667	0.786	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) SlyX (PF04102, IPR007236): SlyX XhlA (PF10779, IPR019715): Haemolysin XhlA TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding Imm7 (PF15585, IPR028965): Immunity protein 7 CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
40	SERPINH1	interactor	4	0.833	0.500	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
41	SMARCA4	suppressor	10	0.622	8.804	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
42	SMARCC2	interactor	8	0.714	4.667	GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain SWIRM (PF04433, IPR007526): SWIRM domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
43	SMARCE1	interactor	7	0.810	2.333	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1) Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
44	SNAI1	oncoprotein	8	0.786	2.537	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
45	SUB1	interactor	4	0.667	1.000	Dehydrin (PF00257, IPR000167): Dehydrin PC4 (PF02229, IPR003173): Transcriptional Coactivator p15 (PC4)
46	SUMO2	interactor	7	0.800	1.667	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
47	TAL1	oncoprotein	6	0.900	0.500	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
48	TCF3	suppressor	6	0.800	1.167	CDC45 (PF02724, IPR003874): CDC45-like protein HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
49	TP53BP1	suppressor	5	0.600	3.400	53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
50	TRIP4	interactor	4	1.000	0	ASCH (PF04266, IPR007374, SM01022): ASCH domain UxaC (PF02614, IPR003766): Glucuronate isomerase zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
51	ZMYM2	oncoprotein	8	0.679	5.252	YHS (PF04945, IPR007029): YHS domain zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504) SOBP (PF15279, IPR026092): Sine oculis-binding protein
52	ZNF217	oncoprotein	8	0.786	2.567	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF2256 (PF10013, IPR017136): Uncharacterized protein conserved in bacteria (DUF2256) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain HiaBD2 (PF15403, IPR029275): HiaBD2_N domain of Trimeric autotransporter adhesin (GIN)

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