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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins2 (8.33 %)
The number (and %) of the tumor suppressors1 (4.17 %)
Total number of binary PPIs (saturation %)67 (24.28 %)
The number (and %) of affected PPIs24 (35.82 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI4.750
Assortativity coefficient-0.4706
The network average Clustering coefficient0.493
The number (and %) of a zero Clustering coefficients6 (25.00 %)
The number (and %) of a zero Betweenness Centrality10 (41.67 %)


List of the fusions

PPI for parental proteins: RCC1L All fusions
Proteins found in more fusions RCC1L (see 1 fusions); ATXN1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RCC1Lparental protein240.134365.233RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
2 ATXN1protein found in more fusions200AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
3 BRCA1suppressor200BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
4 C6orf203interactor60.6002.333Bystin (PF05291, IPR007955): Bystin
DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
5 CLPBinteractor30.6670.400AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
Torsin (PF06309, IPR010448): Torsin
ClpB_D2-small (PF10431, IPR019489, SM01086): C-terminal, D2-small domain, of ClpB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_33 (PF13671): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
6 COQ2interactor50.6671.667UbiA (PF01040, IPR000537): UbiA prenyltransferase family
7 DHRS4interactor70.4005.833adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
8 ECH1interactor80.35715.567ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
9 ETFRF1interactor31.0000Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
10 GOLPH3interactor100GPP34 (PF05719, IPR008628): Golgi phosphoprotein 3 (GPP34)
11 HNRNPUinteractor50.9000.500CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
12 HOGA1interactor41.0000DHDPS (PF00701, IPR002220, SM01130): Dihydrodipicolinate synthetase family
13 MRPL45interactor31.0000Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
14 MRPL50interactor60.7332.500Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
15 MRPL58interactor100.44420.000RF-1 (PF00472, IPR000352): RF-1 domain
16 NME6interactor30.6670.667NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
17 NRDCinteractor50.5001.400Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
18 NUDT19interactor100NUDIX (PF00293, IPR000086): NUDIX domain
19 PMPCAinteractor50.7001.667Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
20 PMPCBinteractor50.7001.567Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
21 RBBP6oncoprotein100DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
DWNN (PF08783, IPR014891): DWNN domain
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
U-box (PF04564, IPR003613, SM00504): U-box domain
SBF2 (PF12335, IPR022096): Myotubularin protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
PRIMA1 (PF16101): Proline-rich membrane anchor 1
22 STARD7interactor100START (PF01852, IPR002913, SM00234): START domain
23 SYNCRIPinteractor41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
24 TRUB2interactor100.36118.667TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain

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