Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins RBMX (from a repository: Tue Nov 15 15:50:30 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 142 The number (and %) of the onco-proteins 32 (22.54 %) The number (and %) of the tumor suppressors 15 (10.56 %) Total number of binary PPIs (saturation %) 1586 (15.84 %) The number (and %) of affected PPIs 142 (8.95 %) The number of possible different fusions 22 PPI diameter 2 PPI radius 1 The average degree of PPI 21.479 Assortativity coefficient -0.1876 The network average Clustering coefficient 0.528 The number (and %) of a zero Clustering coefficients 6 (4.23 %) The number (and %) of a zero Betweenness Centrality 19 (13.38 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: RBMX	All fusions : AA460375; AA460960; AA461092;
Proteins found in more fusions	RBMX (see 3 fusions); STAU1 (see 2 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); RAC1 (see 1 fusions); IVNS1ABP (see 2 fusions); HDAC5 (see 1 fusions); DDX5 (see 1 fusions); SNW1 (see 1 fusions); ITSN2 (see 1 fusions); SREK1 (see 4 fusions); JAK2 (see 3 fusions); NCOA5 (see 1 fusions); SRPK2 (see 1 fusions); HNRNPD (see 1 fusions); KHDRBS1 (see 1 fusions); MCM2 (see 1 fusions); CSNK2A1 (see 1 fusions); QKI (see 3 fusions); HNRNPC (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	RBMX	parental protein	142	0.140	9176.290	RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2	AHSA1	interactor	11	0.709	2.923	Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
3	APOBEC3C	interactor	7	0.333	6.569	APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
4	C10orf2	interactor	2	1.000	0	T2SSE (PF00437, IPR001482): Type II/IV secretion system protein SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain AAA_25 (PF13481): AAA domain
5	CAND1	interactor	62	0.350	395.601	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
6	CCDC33	interactor	5	0.600	1.619	C2 (PF00168, IPR000008, SM00239): C2 domain DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat SlyX (PF04102, IPR007236): SlyX
7	CCDC8	interactor	24	0.553	30.267	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
8	CDC5L	interactor	47	0.502	111.562	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
9	CIRBP	oncoprotein	21	0.386	51.239	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10	CLK1	interactor	15	0.538	9.240	PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region Pkinase (PF00069, IPR000719): Protein kinase domain
11	CLK3	interactor	9	0.536	7.786	Pkinase (PF00069, IPR000719): Protein kinase domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
12	CNBP	oncoprotein	10	0.489	8.196	zf-CCHC (PF00098, IPR001878): Zinc knuckle zf-ribbon_3 (PF13248): zinc-ribbon domain
13	CSNK2A1	oncoprotein	22	0.424	26.856	Pkinase (PF00069, IPR000719): Protein kinase domain
14	CTNNB1	oncoprotein	16	0.600	13.935	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
15	CUL3	protein found in more fusions	65	0.314	500.608	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
16	CUL7	protein found in more fusions	46	0.433	120.868	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
17	DDX5	oncoprotein	49	0.481	123.664	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
18	DHX15	interactor	43	0.492	93.047	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
19	DHX36	interactor	11	0.509	4.744	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
20	EED	suppressor	41	0.412	138.536	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
21	EEF1A1	suppressor	34	0.428	73.501	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
22	EIF4A3	interactor	48	0.500	124.541	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23	ELAVL2	interactor	4	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24	ESR1	suppressor	33	0.458	72.478	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
25	FAM103A1	interactor	4	0.667	0.800	RAM (PF15320, IPR028271): mRNA cap methylation, RNMT-activating mini protein
26	FAM120A	interactor	14	0.648	4.289	TPR_15 (PF13429): Tetratricopeptide repeat
27	FASTKD2	interactor	3	1.000	0	FAST_1 (PF06743, IPR010622): FAST kinase-like protein, subdomain 1 FAST_2 (PF08368, IPR013579): FAST kinase-like protein, subdomain 2 RAP (PF08373, IPR013584, SM00952): RAP domain
28	FBXO6	interactor	21	0.529	22.936	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
29	FBXW11	interactor	26	0.307	83.568	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
30	FBXW7	suppressor	7	0.533	1.384	Mem_trans (PF03547, IPR004776): Membrane transport protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 F-box-like (PF12937, IPR001810): F-box-like
31	FN1	oncoprotein	40	0.387	149.418	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
32	FOXL2	suppressor	2	1.000	0	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
33	FOXM1	oncoprotein	1	0	0	EspF (PF04806, IPR006891): EspF protein repeat Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
34	FOXS1	interactor	2	1.000	0	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
35	FUS	suppressor	38	0.450	90.743	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
36	FXR2	interactor	11	0.444	13.765	Agenet (PF05641, IPR008395, SM00743): Agenet domain REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein) KH_1 (PF00013, IPR004088, SM00322): KH domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
37	GID8	interactor	2	0	0	LisH (PF08513, IPR013720, SM00667): LisH CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
38	GSTP1	suppressor	12	0.636	2.003	GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
39	HDAC5	protein found in more fusions	23	0.593	12.618	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
40	HDGF	interactor	8	0.821	0.472	PWWP (PF00855, IPR000313, SM00293): PWWP domain
41	HNRNPA0	interactor	38	0.556	53.943	SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
42	HNRNPA1	interactor	80	0.282	1006.446	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
43	HNRNPC	protein found in more fusions	49	0.376	193.405	APG6 (PF04111, IPR007243): Autophagy protein Apg6 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
44	HNRNPD	oncoprotein	44	0.396	156.084	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
45	HNRNPF	interactor	41	0.532	78.269	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
46	HNRNPH1	oncoprotein	43	0.517	80.533	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
47	HNRNPH2	interactor	32	0.557	39.661	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
48	HNRNPK	oncoprotein	64	0.364	486.123	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
49	HNRNPM	interactor	46	0.495	109.176	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
50	HNRNPR	interactor	53	0.454	186.147	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
51	HNRNPUL1	interactor	31	0.393	72.960	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
52	HPD	interactor	1	0	0	Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 (PF13468, IPR025870): Glyoxalase-like domain
53	IFIT3	interactor	6	0.600	0.461	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
54	IL7R	interactor	19	0.339	23.748	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
55	ITGA4	interactor	32	0.516	50.000	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
56	ITSN2	protein found in more fusions	5	0.667	0.800	C2 (PF00168, IPR000008, SM00239): C2 domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) SH3_9 (PF14604, IPR001452): Variant SH3 domain MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26 VIR_N (PF15912, IPR031801): Virilizer, N-terminal PH_13 (PF16652, IPR001849): Pleckstrin homology domain
57	IVNS1ABP	protein found in more fusions	14	0.641	5.861	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
58	JAK2	oncoprotein	5	0.500	2.667	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
59	KHDRBS1	protein found in more fusions	32	0.477	71.088	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
60	KHDRBS2	interactor	21	0.426	43.207	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
61	KHDRBS3	interactor	16	0.381	35.675	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
62	LNX1	interactor	7	0.400	6.183	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
63	LUZP4	interactor	12	0.455	6.929	Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
64	MAGOH	interactor	27	0.504	32.881	Mago_nashi (PF02792, IPR004023): Mago nashi protein
65	MAGOHB	interactor	4	0.500	0.545	Mago_nashi (PF02792, IPR004023): Mago nashi protein
66	MALSU1	interactor	2	1.000	0	RsfS (PF02410, IPR025656): Ribosomal silencing factor during starvation
67	MATR3	interactor	45	0.451	129.217	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM60A (PF15396, IPR026065): Protein Family FAM60A
68	MCAT	interactor	2	1.000	0	Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
69	MCM2	oncoprotein	44	0.403	185.302	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
70	MCM5	oncoprotein	23	0.589	13.662	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
71	MEPCE	interactor	16	0.800	2.383	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
72	MTERF3	interactor	5	0.700	1.278	mTERF (PF02536, IPR003690, SM00733): mTERF Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
73	NABP1	interactor	4	0.500	1.833	tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
74	NCOA5	suppressor	14	0.397	21.808	Macoilin (PF09726, IPR019130): Transmembrane protein
75	NFE2L2	oncoprotein	4	0.667	1.105	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
76	NGRN	interactor	2	1.000	0	Neugrin (PF06413, IPR010487): Neugrin
77	NIF3L1	interactor	3	1.000	0	NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
78	NTRK1	oncoprotein	57	0.360	299.113	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
79	NUCKS1	interactor	1	0	0	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4 PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
80	NXF1	interactor	35	0.383	111.712	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
81	OBSL1	interactor	46	0.439	102.603	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
82	P3H2	interactor	1	0	0	TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat YfiO (PF13525): Outer membrane lipoprotein 2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
83	PAIP1	interactor	5	1.000	0	MIF4G (PF02854, IPR003890, SM00543): MIF4G domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
84	PAN2	interactor	14	0.462	14.203	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
85	PPP1CB	interactor	17	0.338	34.064	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
86	PPP1CC	oncoprotein	11	0.291	21.716	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
87	PPP2R1A	oncoprotein	20	0.458	29.881	TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
88	PRR3	interactor	7	0.619	3.486	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
89	PSMF1	interactor	4	0.667	0.500	PI31_Prot_C (PF08577, IPR013886): PI31 proteasome regulator PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
90	PTCD1	interactor	5	0.700	0.511	PPR_2 (PF13041, IPR002885): PPR repeat family PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
91	QKI	protein found in more fusions	13	0.439	20.051	KH_1 (PF00013, IPR004088, SM00322): KH domain STAR_dimer (PF16544, IPR032377): Homodimerisation region of STAR domain protein Quaking_NLS (PF16551, IPR032367): Putative nuclear localisation signal of quaking
92	RAC1	oncoprotein	7	0.733	0.408	Ras (PF00071, IPR001806, SM00173): Ras family
93	RALY	interactor	28	0.566	79.936	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
94	RB1CC1	suppressor	5	0.600	1.143	Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II DHC (PF09626, IPR018588): Dihaem cytochrome c DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) ATG11 (PF10377, IPR019460): Autophagy-related protein 11 DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Jag_N (PF14804, IPR032782): Jag N-terminus NPBW (PF15180, IPR013297): Neuropeptides B and W HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
95	RBM14	suppressor	28	0.479	38.091	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
96	RBM3	interactor	15	0.524	16.296	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
97	RBM45	interactor	8	0.810	2.667	RNA_bind (PF08675, IPR014789): RNA binding domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
98	RBM7	interactor	14	0.538	14.377	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
99	RBM8A	interactor	17	0.517	17.902	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
100	RBMY1A1	interactor	9	0.393	10.048	RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sulfakinin (PF08257, IPR013259): Sulfakinin family BMP2K_C (PF15282, IPR028182): BMP-2-inducible protein kinase C-terminus
101	RBMY1F	interactor	10	0.333	13.548	RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sulfakinin (PF08257, IPR013259): Sulfakinin family
102	RNF2	interactor	33	0.403	71.819	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
103	ROBO3	interactor	2	1.000	0	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
104	RPL31	interactor	18	0.503	17.510	Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
105	RPS28	interactor	12	0.652	2.580	Ribosomal_S28e (PF01200, IPR000289): Ribosomal protein S28e
106	RPSA	interactor	29	0.433	54.793	Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2 40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
107	RRM2	interactor	2	1.000	0	Ribonuc_red_sm (PF00268, IPR000358): Ribonucleotide reductase, small chain
108	SAFB	suppressor	26	0.385	73.122	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
109	SAFB2	suppressor	16	0.500	23.669	LicD (PF04991, IPR007074): LicD family Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228) Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
110	SCARNA22	interactor	17	0.676	4.070	NA
111	SF3A1	interactor	37	0.538	52.809	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
112	SF3A2	interactor	29	0.525	51.593	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
113	SF3B1	oncoprotein	45	0.436	112.495	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1 UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
114	SF3B2	interactor	32	0.460	54.858	DUF382 (PF04037, IPR007180): Domain of unknown function (DUF382) PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region PSP (PF04046, IPR006568, SM00581): PSP SAP (PF02037, IPR003034, SM00513): SAP domain Usp (PF00582, IPR006016): Universal stress protein family Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 Vma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
115	SF3B3	interactor	37	0.521	69.274	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
116	SF3B4	interactor	22	0.571	22.256	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
117	SF3B6	interactor	21	0.514	20.052	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
118	SIRT7	interactor	28	0.307	77.586	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
119	SNRPA	interactor	26	0.483	40.787	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
120	SNW1	protein found in more fusions	41	0.565	83.168	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
121	SOCS3	suppressor	2	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
122	SORBS3	interactor	5	0.667	0.273	Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
123	SPICE1	interactor	4	0.500	1.889	SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression ANXA2R (PF15721, IPR031449): Annexin-2 receptor JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
124	SREK1	protein found in more fusions	15	0.527	8.341	Ureide_permease (PF07168, IPR009834): Ureide permease RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
125	SRPK2	oncoprotein	34	0.432	122.973	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
126	SRPK3	interactor	11	0.564	3.963	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pkinase (PF00069, IPR000719): Protein kinase domain
127	SRRM1	interactor	31	0.499	50.586	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
128	SRRM2	interactor	40	0.492	107.604	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
129	STAT5A	suppressor	6	0.400	4.433	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
130	STAU1	protein found in more fusions	36	0.518	69.406	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
131	TARDBP	interactor	42	0.474	117.147	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
132	TRA2B	interactor	20	0.463	35.959	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
133	TRUB2	interactor	5	0.833	0.500	TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
134	U2AF2	protein found in more fusions	48	0.499	114.099	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
135	USP45	interactor	5	0.400	1.497	HNH (PF01844, IPR002711): HNH endonuclease UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein LELP1 (PF15042, IPR026076): Late cornified envelope-like proline-rich protein 1
136	VCAM1	interactor	28	0.484	41.513	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
137	WWOX	suppressor	19	0.556	12.395	adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain
138	XRN1	interactor	6	0.733	0.449	XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus
139	YARS2	interactor	5	0.800	1.167	S4 (PF01479, IPR002942, SM00363): S4 domain tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
140	YTHDC1	interactor	12	0.576	11.266	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family YTH (PF04146, IPR007275): YT521-B-like domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term TFB6 (PF17110, IPR031349): Subunit 11 of the general transcription factor TFIIH
141	ZC3H18	interactor	19	0.433	26.398	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal Miga (PF10265, IPR019392): Mitoguardin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal LRR19-TM (PF15176): Leucine-rich repeat family 19 TM domain
142	ZNF490	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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