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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins17 (41.46 %)
The number (and %) of the tumor suppressors5 (12.20 %)
Total number of binary PPIs (saturation %)107 (13.05 %)
The number (and %) of affected PPIs41 (38.32 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI4.439
Assortativity coefficient-0.3801
The network average Clustering coefficient0.511
The number (and %) of a zero Clustering coefficients13 (31.71 %)
The number (and %) of a zero Betweenness Centrality23 (56.10 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions AMOTL2 (see 1 fusions); KPNB1 (see 2 fusions); UBQLN1 (see 2 fusions); STK3 (see 1 fusions); RASSF5 (see 2 fusions); SMAD4 (see 2 fusions); MYLIP (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RASSF5parental protein410.0651356.700RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
2 ADH6interactor21.0000ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
3 AGLinteractor100GDE_C (PF06202, IPR010401): Amylo-alpha-1,6-glucosidase
hGDE_N (PF14699, IPR029436): N-terminal domain from the human glycogen debranching enzyme
hDGE_amylase (PF14701, IPR032792): Glucanotransferase of human glycogen debranching enzyme
hGDE_central (PF14702, IPR032788): Central domain of human glycogen debranching enzyme
4 AMOTL2protein found in more fusions40.6671.000HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
5 APPBP2interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
6 BTRConcoprotein110.37825.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
7 ERP44interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
8 FLNCinteractor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
9 HIPK1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
10 HRASoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
11 ITCHinteractor40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
12 KCTD12interactor31.0000BTB_2 (PF02214, IPR003131): BTB/POZ domain
13 KPNB1protein found in more fusions40.6671.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
14 KRASoncoprotein70.3339.500Ras (PF00071, IPR001806, SM00173): Ras family
15 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
16 KRTAP4-2interactor21.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
17 LSM7interactor100LSM (PF01423, IPR001163): LSM domain
18 MAP1Binteractor70.8571.300DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
Striatin (PF08232, IPR013258): Striatin family
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
19 MAP1LC3Ainteractor70.7145.400Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
20 MAP1LC3Binteractor51.0000Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
21 MAP1Sinteractor70.8571.300Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
22 MDM2oncoprotein50.6672.000Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
23 MOB1Asuppressor51.0000Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
24 MOB1Bsuppressor51.0000Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
25 MRASoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
26 MYLIPprotein found in more fusions31.0000FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
27 RABIFinteractor21.0000Mss4 (PF04421, IPR007515): Mss4 protein
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
28 RAP1Boncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
29 RAP2Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
30 RAP2Boncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
31 RASSF1suppressor90.6437.067RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
32 RASSF2suppressor60.7333.333RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
33 RELoncoprotein30.6671.000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
34 RRASoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
35 SMAD4suppressor40.6671.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
36 STK3protein found in more fusions130.48524.700Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
37 STK4oncoprotein120.56414.700Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
38 TRAF1oncoprotein40.6671.000HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
39 TRAF2interactor40.6671.000MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
40 UBQLN1protein found in more fusions31.0000Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
41 VPS28interactor100VPS28 (PF03997, IPR007143): VPS28 protein

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