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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RAP1GDS1, NUP98 (from a repository: Sun Dec 18 08:55:01 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)128
The number (and %) of the onco-proteins49 (38.28 %)
The number (and %) of the tumor suppressors15 (11.72 %)
Total number of binary PPIs (saturation %)767 (9.44 %)
The number (and %) of affected PPIs127 (16.56 %)
The number of possible different fusions26
PPI diameter4
PPI radius2
The average degree of PPI11.297
Assortativity coefficient-0.1839
The network average Clustering coefficient0.383
The number (and %) of a zero Clustering coefficients18 (14.06 %)
The number (and %) of a zero Betweenness Centrality23 (17.97 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: NUP98,RAP1GDS1 All fusions
: AF133334; AF133332; AF133331;
Proteins found in more fusions LMNA (see 3 fusions); PUF60 (see 2 fusions); HNRNPUL1 (see 1 fusions); NPM1 (see 1 fusions); KPNB1 (see 2 fusions); HDAC7 (see 1 fusions); CUL7 (see 2 fusions); RAC1 (see 1 fusions); GMDS (see 1 fusions); FAF1 (see 2 fusions); NUP153 (see 2 fusions); CREBBP (see 6 fusions); UBQLN1 (see 2 fusions); GSS (see 1 fusions); EGFR (see 2 fusions); APC (see 1 fusions); VCL (see 2 fusions); CSNK2A1 (see 1 fusions); ECHS1 (see 1 fusions); NUDT21 (see 2 fusions); EP300 (see 1 fusions); NTRK1/TPR (see 1 fusions); CDC37 (see 2 fusions); ZNF451 (see 1 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NUP98parental protein660.1293772.354Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase
Nup96 (PF12110, IPR021967): Nuclear protein 96
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
2 RAP1GDS1parental protein610.0924994.521Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
3 ABHD14Ainteractor80.7143.022Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
4 APBB2interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
WW (PF00397, IPR001202, SM00456): WW domain
5 APCsuppressor130.273120.406APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
6 ARFGEF2interactor40.6671.167DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
7 ASNSoncoprotein140.48441.986Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
8 B9D2interactor90.7783.407B9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 protein
9 BAIAP2interactor70.33314.176IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
10 C2orf48interactor100NA
11 CAPN1interactor80.57173.697Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12 CDC37protein found in more fusions150.34195.392CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
13 CDC42oncoprotein80.19088.456Ras (PF00071, IPR001806, SM00173): Ras family
14 CDC73suppressor80.42937.142CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
15 CDK2suppressor240.296300.834Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
16 CHMP4Binteractor31.0000Snf7 (PF03357, IPR005024): Snf7
17 CLEC11Ainteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HBS1_N (PF08938, IPR015033): HBS1 N-terminus
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
18 COMTD1interactor40.33311.003FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
19 CREBBPsuppressor110.46754.292Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
20 CSNK2A1oncoprotein130.34840.790Pkinase (PF00069, IPR000719): Protein kinase domain
21 CTNNB1oncoprotein200.253185.215Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
22 CUL7protein found in more fusions260.267279.632ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
23 DCPSinteractor140.51634.708DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
24 DIRAS3suppressor40.33323.244ArgK (PF03308, IPR005129): ArgK protein
Ras (PF00071, IPR001806, SM00173): Ras family
VirE (PF05272, IPR007936): Virulence-associated protein E
25 DOC2Ainteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
26 ECHS1protein found in more fusions160.44890.330ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
27 ECT2suppressor40.50017.376BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
28 EEDsuppressor210.216226.492WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
29 EGFRoncoprotein230.186503.403Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
30 EP300oncoprotein140.35972.726Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
31 FAF1protein found in more fusions90.35727.430UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
32 FBXO6interactor120.37945.250FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
33 FOXI2interactor41.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
34 FOXL1oncoprotein40.5004.408Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
35 FOXQ1interactor70.47613.849Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
36 GAPDHoncoprotein190.281237.154Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
37 GINS3interactor120.63612.303Sld5 (PF05916, IPR021151): GINS complex protein
38 GMDSprotein found in more fusions50.50084.369GDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
39 GNAI1oncoprotein100G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
40 GNAZinteractor200G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
41 GSSprotein found in more fusions150.49524.029GSH_synth_ATP (PF03917, IPR005615): Eukaryotic glutathione synthase, ATP binding domain
42 GTF2H5interactor30.33340.309Tfb5 (PF06331, IPR009400): Transcription factor TFIIH complex subunit Tfb5
43 HDAC1suppressor150.28688.973FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
44 HDAC11interactor40.8330.125Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
45 HDAC7protein found in more fusions90.32145.443Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
46 HDAC8interactor100DNase-RNase (PF02577, IPR003729): Bifunctional nuclease
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
47 HNRNPUL1protein found in more fusions110.46717.296Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
48 HRASoncoprotein40.16729.215Ras (PF00071, IPR001806, SM00173): Ras family
49 HSPA1Linteractor40.6670.827HSP70 (PF00012, IPR013126): Hsp70 protein
50 HSPA5oncoprotein230.242381.578HSP70 (PF00012, IPR013126): Hsp70 protein
51 HSPA9oncoprotein200.300203.912HSP70 (PF00012, IPR013126): Hsp70 protein
52 HSPB9interactor100HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
53 IFI16suppressor190.409119.083HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
54 KIFAP3interactor40.33337.203KAP (PF05804): Kinesin-associated protein (KAP)
55 KPNB1protein found in more fusions320.297484.126Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
56 KRASoncoprotein110.289411.452Ras (PF00071, IPR001806, SM00173): Ras family
57 LMNAprotein found in more fusions180.42641.753Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
58 MAPK8oncoprotein100.250167.855DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
59 MBIPinteractor200DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
60 MOB1Asuppressor100Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
61 MOV10interactor200.226246.387AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
62 MSNoncoprotein200.374146.109DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
63 NAE1interactor90.58320.078ThiF (PF00899, IPR000594): ThiF family
64 NCBP2interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
65 NPM1suppressor200.40478.727Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
66 NRASoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
67 NTRK1oncoprotein480.1411715.636I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
68 NUDT21protein found in more fusions100.38934.542NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
69 NUMA1oncoprotein170.382117.728Colicin (PF01024, IPR000293): Colicin pore forming domain
Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848)
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
70 NUP107interactor300.363297.238Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107
71 NUP133oncoprotein200.400127.857Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal
72 NUP153protein found in more fusions270.403166.345Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like
Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
73 NUP160interactor190.49795.231Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
74 NUP35interactor130.60325.947Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
75 NUP43interactor120.7887.024WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
76 NUP54interactor130.51346.477Regulator_TrmB (PF11495, IPR021586): Archaeal transcriptional regulator TrmB
KRTAP (PF11759, IPR021743): Keratin-associated matrix
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
77 NUP58interactor100.48946.001Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
78 NUP85interactor210.376206.630Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
79 NUP88interactor130.61549.087Nup88 (PF10168, IPR019321): Nuclear pore component
80 NXF1interactor330.240502.873NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
81 OBSL1interactor290.283239.045BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
82 OLA1interactor70.52418.982Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
83 PAF1oncoprotein60.46721.550Paf1 (PF03985, IPR007133): Paf1
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
84 PAFAH1B2oncoprotein120.50025.467Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
85 PARP11interactor31.0000PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
WWE (PF02825, IPR004170, SM00678): WWE domain
86 PDIA4interactor160.467104.191Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
87 PFASinteractor140.52754.957AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
88 PIM2oncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
89 PLEKHB1oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
Bacteriocin_IIc (PF10439, IPR019493): Bacteriocin class II with double-glycine leader peptide
90 PNKDinteractor50.7001.667Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
91 PPP1R2interactor90.55674.217IPP-2 (PF04979, IPR007062): Protein phosphatase inhibitor 2 (IPP-2)
92 PPP5Cinteractor140.37497.552Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PPP5 (PF08321, IPR013235): PPP5 TPR repeat region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
93 PTMAoncoprotein120.394119.748Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
94 PTTG1oncoprotein50.6671.667Securin (PF04856, IPR006940): Securin sister-chromatid separation inhibitor
95 PUF60protein found in more fusions140.179195.044RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
96 QRICH2interactor204.748Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
GLTT (PF01744, IPR008164): GLTT repeat (6 copies)
Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
97 RAB1Boncoprotein30.3339.113Ras (PF00071, IPR001806, SM00173): Ras family
98 RAB31oncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
99 RAB34oncoprotein30.3335.511Ras (PF00071, IPR001806, SM00173): Ras family
100 RAC1oncoprotein60.40026.830Ras (PF00071, IPR001806, SM00173): Ras family
101 RAE1interactor170.44150.928Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
102 RAP1Asuppressor80.214117.219Ras (PF00071, IPR001806, SM00173): Ras family
103 RAPGEF3interactor30.3339.702DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
BAT (PF15915, IPR031803): GAF and HTH_10 associated domain
104 RASD2interactor100Ras (PF00071, IPR001806, SM00173): Ras family
105 RASL10Asuppressor21.0000Ras (PF00071, IPR001806, SM00173): Ras family
106 RHOAsuppressor80.28653.448Ras (PF00071, IPR001806, SM00173): Ras family
107 RNF166interactor60.46779.794zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
108 SEC13interactor120.69124.829WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
109 SEH1Linteractor150.69515.701WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
110 SEPT12interactor21.0000Septin (PF00735, IPR000038): Septin
111 SEPT6oncoprotein30.6675.617Septin (PF00735, IPR000038): Septin
DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
112 SIRT7interactor280.246365.436DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
113 SNX24interactor100PX (PF00787, IPR001683, SM00312): PX domain
114 TATDN1interactor100.46752.559TatD_DNase (PF01026, IPR001130): TatD related DNase
115 TNPO1interactor80.5008.428Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
116 TNPO2interactor70.23847.681Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Dopey_N (PF04118, IPR007249): Dopey, N-terminal
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
DUF2573 (PF10835, IPR020393): Protein of unknown function (DUF2573)
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
117 TPRoncoprotein130.50074.036Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3373 (PF11853, IPR021803): Protein of unknown function (DUF3373)
DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
118 TSC22D4interactor21.0000AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
119 UBE2Iinteractor210.247354.050UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
120 UBQLN1protein found in more fusions100.222159.599Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
121 UNC45Ainteractor50.50034.139Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
TPR_16 (PF13432): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
122 UNKinteractor120.152123.176MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
123 USP14interactor90.36149.246UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
124 USP7oncoprotein110.33335.461MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
125 VCLoncoprotein200.44493.443Vinculin (PF01044, IPR006077): Vinculin family
126 XPO5suppressor80.50017.032IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
127 YWHAEoncoprotein200.305237.52814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
128 ZNF451protein found in more fusions3013.033zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Cys_rich_KTR (PF14205, IPR025957): Cysteine-rich KTR
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ARFGEF2interactorDUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
AF133331, AF133332, AF133334
2 B9D2interactorB9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 proteinAF133331, AF133332, AF133334
3 C2orf48interactorNAAF133331, AF133332, AF133334
4 CDC37interactorCDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
AF133331, AF133332, AF133334
5 CDC73suppressorCDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
AF133331, AF133332, AF133334
6 CHMP4BinteractorSnf7 (PF03357, IPR005024): Snf7AF133331, AF133332, AF133334
7 CLEC11AinteractorATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HBS1_N (PF08938, IPR015033): HBS1 N-terminus
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
AF133331, AF133332, AF133334
8 FBXO6interactorFBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
AF133331, AF133332, AF133334
9 FOXI2interactorForkhead (PF00250, IPR001766, SM00339): Forkhead domainAF133331, AF133332, AF133334
10 FOXL1oncoproteinForkhead (PF00250, IPR001766, SM00339): Forkhead domainAF133331, AF133332, AF133334
11 FOXQ1interactorForkhead (PF00250, IPR001766, SM00339): Forkhead domainAF133331, AF133332, AF133334
12 GTF2H5interactorTfb5 (PF06331, IPR009400): Transcription factor TFIIH complex subunit Tfb5AF133331, AF133332, AF133334
13 HDAC8interactorDNase-RNase (PF02577, IPR003729): Bifunctional nuclease
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
AF133331, AF133332, AF133334
14 HNRNPUL1interactorMito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
AF133331, AF133332, AF133334
15 MAPK8oncoproteinDUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
AF133331, AF133332, AF133334
16 MOB1AsuppressorMob1_phocein (PF03637, IPR005301): Mob1/phocein familyAF133331, AF133332, AF133334
17 NPM1suppressorNucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
AF133331, AF133332, AF133334
18 NUDT21interactorNUDIX_2 (PF13869, IPR016706): Nucleotide hydrolaseAF133331, AF133332, AF133334
19 NUP160interactorNup160 (PF11715, IPR021717): Nucleoporin Nup120/160AF133331, AF133332
20 NUP35interactorNup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motifAF133331, AF133332, AF133334
21 NUP54interactorRegulator_TrmB (PF11495, IPR021586): Archaeal transcriptional regulator TrmB
KRTAP (PF11759, IPR021743): Keratin-associated matrix
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
AF133331, AF133332, AF133334
22 NUP85interactorNucleopor_Nup85 (PF07575, IPR011502): Nup85 NucleoporinAF133334
23 NUP88interactorNup88 (PF10168, IPR019321): Nuclear pore componentAF133331, AF133332, AF133334
24 NUP98parental proteinNucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase
Nup96 (PF12110, IPR021967): Nuclear protein 96
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
AF133331, AF133332, AF133334
25 PAF1oncoproteinPaf1 (PF03985, IPR007133): Paf1
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
AF133331, AF133332, AF133334
26 PARP11interactorPARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
WWE (PF02825, IPR004170, SM00678): WWE domain
AF133331, AF133332, AF133334
27 PNKDinteractorLactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
AF133331, AF133332, AF133334
28 PTTG1oncoproteinSecurin (PF04856, IPR006940): Securin sister-chromatid separation inhibitorAF133331, AF133332, AF133334
29 QRICH2interactorBaculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
GLTT (PF01744, IPR008164): GLTT repeat (6 copies)
Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
AF133331, AF133332, AF133334
30 RAP1GDS1parental proteinArm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
AF133331, AF133332, AF133334
31 RAPGEF3interactorDEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
BAT (PF15915, IPR031803): GAF and HTH_10 associated domain
AF133331, AF133332, AF133334
32 RNF166interactorzf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
AF133331, AF133332, AF133334
33 SEC13interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
AF133331, AF133332, AF133334
34 SEH1LinteractorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
AF133331, AF133332, AF133334
35 UNKinteractorMbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
AF133331, AF133332, AF133334
36 USP7oncoproteinMATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
AF133331, AF133332, AF133334

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