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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)309
The number (and %) of the onco-proteins107 (34.63 %)
The number (and %) of the tumor suppressors48 (15.53 %)
Total number of binary PPIs (saturation %)2916 (6.13 %)
The number (and %) of affected PPIs314 (10.77 %)
The number of possible different fusions59
PPI diameter3
PPI radius2
The average degree of PPI18.071
Assortativity coefficient-0.1566
The network average Clustering coefficient0.327
The number (and %) of a zero Clustering coefficients39 (12.62 %)
The number (and %) of a zero Betweenness Centrality32 (10.36 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RAC1,PKM All fusions
: CD365065;
Proteins found in more fusions U2AF2 (see 2 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); EWSR1 (see 2 fusions); CCDC88A (see 3 fusions); SH3RF1 (see 1 fusions); NAGK (see 1 fusions); HDAC5 (see 1 fusions); EP300 (see 1 fusions); PRDX6 (see 1 fusions); PKM/FUS (see 1 fusions); NEDD4 (see 1 fusions); SUZ12 (see 2 fusions); HSPB1/OBSL1 (see 1 fusions); APP (see 4 fusions); TNF (see 1 fusions); VCP (see 4 fusions); TKT (see 5 fusions); HSP90AA1 (see 2 fusions); SFPQ (see 6 fusions); HUWE1 (see 2 fusions); HSP90AB1 (see 1 fusions); PAK4 (see 1 fusions); EEF1D (see 3 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); FMNL1 (see 1 fusions); ACAT2 (see 1 fusions); HSPB1 (see 3 fusions); NLK (see 4 fusions); RAC1/PKM (see 1 fusions); PTK2 (see 2 fusions); EZH2 (see 1 fusions); CDC37 (see 2 fusions); PML (see 4 fusions); EGLN1 (see 1 fusions); CBS (see 1 fusions); GAPDH (see 2 fusions); RBMX (see 3 fusions); STAU1 (see 2 fusions); CUL7 (see 2 fusions); PPME1 (see 1 fusions); CUL3 (see 1 fusions); RAC1 (see 1 fusions); USH1C (see 1 fusions); GAPDH/CDKN1A (see 1 fusions); ACTB (see 3 fusions); COPS5 (see 1 fusions); PAK2 (see 2 fusions); UBC (see 1 fusions); LRRK2 (see 1 fusions); PFKL (see 2 fusions); KPNB1 (see 2 fusions); HERC1 (see 1 fusions); MCM2 (see 1 fusions); CFL1/EED (see 1 fusions); PFKM (see 1 fusions); FGFR1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RAC1parental protein1520.02532793.629Ras (PF00071, IPR001806, SM00173): Ras family
2 PKMparental protein1630.10621151.080PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
3 ACAT2protein found in more fusions80.42911.819Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ACTBoncoprotein530.2101103.242Actin (PF00022, IPR004000, SM00268): Actin
5 AGLinteractor70.9520.136GDE_C (PF06202, IPR010401): Amylo-alpha-1,6-glucosidase
hGDE_N (PF14699, IPR029436): N-terminal domain from the human glycogen debranching enzyme
hDGE_amylase (PF14701, IPR032792): Glucanotransferase of human glycogen debranching enzyme
hGDE_central (PF14702, IPR032788): Central domain of human glycogen debranching enzyme
6 AKR1A1interactor100.6007.082Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
7 ALDH5A1interactor21.0000Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
8 ALDOAinteractor360.375190.118Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
9 AMDHD2interactor100Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
10 ANP32Asuppressor110.40037.085SDA1 (PF05285, IPR007949): SDA1
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
11 ANXA11interactor170.191445.419Annexin (PF00191, IPR018502, SM00335): Annexin
12 ANXA7suppressor140.27570.175Annexin (PF00191, IPR018502, SM00335): Annexin
13 APPprotein found in more fusions700.0953356.705APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
14 ARAFoncoprotein80.5715.464Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
15 ARFIP2interactor70.06764.825Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
16 ARHGAP1interactor40.33315.682RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
17 ARHGAP15interactor202.740PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
18 ARHGAP17interactor80.25052.899BAR (PF03114, IPR004148, SM00721): BAR domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
19 ARHGAP27interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
WW (PF00397, IPR001202, SM00456): WW domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
20 ARHGAP31interactor100RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
21 ARHGAP32oncoprotein50.20025.579PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
22 ARHGAP33interactor100PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
23 ARHGAP35oncoprotein201.403FF (PF01846, IPR002713, SM00441): FF domain
Ras (PF00071, IPR001806, SM00173): Ras family
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGAP-FF1 (PF16512, IPR032835): p190-A and -B Rho GAPs FF domain
24 ARHGAP44interactor100BAR (PF03114, IPR004148, SM00721): BAR domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
25 ARHGDIAinteractor200.199319.509Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
26 ARHGDIBinteractor60.13356.435Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
27 ARHGEF2oncoprotein70.38130.562IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
28 ARHGEF25interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PH_10 (PF15411): Pleckstrin homology domain
SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
29 ARHGEF4oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30 ARHGEF6oncoprotein60.60010.766CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
31 ARHGEF7interactor90.38972.485Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
32 ARL2BPinteractor100ARL2_Bind_BART (PF11527, IPR023379): The ARF-like 2 binding protein BART
33 ARRB1interactor240.355170.898Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
34 ARRB2interactor390.262641.701Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
35 ASS1suppressor220.257155.972Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
36 ATF2oncoprotein240.257185.023bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
37 BAG6interactor250.174551.092DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
38 BAIAP2interactor90.25049.064IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
39 BANF1interactor60.3009.955BAF (PF02961, IPR004122, SM01023): Barrier to autointegration factor
40 BAXsuppressor90.28627.756Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
41 BCRsuppressor60.33350.191Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
IQ_SEC7_PH (PF16453, IPR001849): PH domain
42 BIRC2oncoprotein100.278151.283BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
43 BRINP1suppressor40.16721.229MACPF (PF01823, IPR020864, SM00457): MAC/Perforin domain
44 C1QAoncoprotein40.6675.236C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
45 C9orf64interactor30.6671.924Q_salvage (PF10343, IPR019438): Potential Queuosine, Q, salvage protein family
46 CAPZA2interactor190.43367.861F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
47 CAV1suppressor180.255162.036Caveolin (PF01146, IPR001612): Caveolin
48 CBSprotein found in more fusions140.48749.736CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
49 CCDC8interactor430.260493.185Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
50 CCDC88Aprotein found in more fusions60.6004.525bZIP_1 (PF00170, IPR004827): bZIP transcription factor
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HOOK (PF05622, IPR008636): HOOK protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
51 CD81interactor250.37050.961Tetraspannin (PF00335, IPR018499): Tetraspanin family
52 CDC23interactor40.3335.911ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
53 CDC37protein found in more fusions260.383114.792CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
54 CDC42BPGinteractor100CNH (PF00780, IPR001180, SM00036): CNH domain
DMPK_coil (PF08826, IPR014930): DMPK coiled coil domain like
ZapB (PF06005, IPR009252): Cell division protein ZapB
IncA (PF04156, IPR007285): IncA protein
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
PH (PF00169, IPR001849, SM00233): PH domain
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
XkdW (PF09636, IPR019094): XkdW protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
55 CDC42SE1interactor100PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
56 CDC42SE2interactor100PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
57 CDK16oncoprotein40.6670.490Pkinase (PF00069, IPR000719): Protein kinase domain
58 CDK2suppressor660.2171486.703Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
59 CDK4oncoprotein200.41157.931Pkinase (PF00069, IPR000719): Protein kinase domain
60 CDKN1Asuppressor230.45870.572CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
61 CFAP36interactor100DUF1068 (PF06364, IPR010471): Protein of unknown function (DUF1068)
ARL2_Bind_BART (PF11527, IPR023379): The ARF-like 2 binding protein BART
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
62 CFL1protein found in more fusions470.290503.915Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
63 CHN2interactor21.0000RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
DUF4127 (PF13552, IPR025394): Protein of unknown function (DUF4127)
64 CITinteractor60.20034.342ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CNH (PF00780, IPR001180, SM00036): CNH domain
Dec-1 (PF04624, IPR006718): Dec-1 repeat
DivIC (PF04977, IPR007060): Septum formation initiator
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Fez1 (PF06818): Fez1
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SlyX (PF04102, IPR007236): SlyX
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
65 CLIP1oncoprotein40.33318.882ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
CP12 (PF02672, IPR003823, SM01093): CP12 domain
DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
SlyX (PF04102, IPR007236): SlyX
ApoO (PF09769, IPR019166): Apolipoprotein O
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Leu_zip (PF15294): Leucine zipper
CLIP1_ZNF (PF16641, IPR032108): CLIP1 zinc knuckle
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
66 CLNS1Ainteractor140.187163.944Voldacs (PF03517): Regulator of volume decrease after cellular swelling
67 CLTConcoprotein430.255741.989Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
68 COG5interactor30.3335.086AceK (PF06315, IPR010452): Isocitrate dehydrogenase kinase/phosphatase (AceK)
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
DUF3800 (PF12686, IPR024524): Protein of unknown function (DUF3800)
69 COPS5protein found in more fusions530.295498.234JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
70 CORO1Concoprotein160.383116.288DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
WD40_4 (PF16300): Type of WD40 repeat
71 COX3interactor100NA
72 CRY1interactor180.243155.966DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
73 CSN2interactor50.20025.105Casein (PF00363, IPR001588): Casein
74 CTPS1interactor150.53815.413CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
75 CUL1suppressor540.308605.665Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
76 CUL2suppressor380.354330.146Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
77 CUL3protein found in more fusions660.251967.075Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
78 CUL5suppressor410.359277.937Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
79 CUL7protein found in more fusions580.229640.984ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
80 DAZAP1interactor270.313342.201RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
81 DDB2suppressor90.32113.311WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
82 DDX3Xsuppressor330.305276.742DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
83 DEF6interactor30.6672.740ArgK (PF03308, IPR005129): ArgK protein
HSP70 (PF00012, IPR013126): Hsp70 protein
PH (PF00169, IPR001849, SM00233): PH domain
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
84 DIAPH3interactor3013.371Drf_DAD (PF06345, IPR010465): DRF Autoregulatory Domain
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
POX (PF07526, IPR006563, SM00574): Associated with HOX
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
85 DMPKinteractor6066.835AP_endonuc_2 (PF01261, IPR013022): Xylose isomerase-like TIM barrel
DMPK_coil (PF08826, IPR014930): DMPK coiled coil domain like
Pkinase (PF00069, IPR000719): Protein kinase domain
86 DNAJA3suppressor110.455121.579DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
87 DOCK1interactor40.5006.405DHR-2 (PF06920, IPR010703): Dock homology region 2
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
TetR_C_8 (PF14278): Transcriptional regulator C-terminal region
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DOCK_N (PF16172, IPR032376): DOCK N-terminus
88 DOCK2oncoprotein70.28637.606DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DOCK_N (PF16172, IPR032376): DOCK N-terminus
89 DOCK8interactor40.33334.834DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DOCK_N (PF16172, IPR032376): DOCK N-terminus
90 EEDsuppressor340.242349.968WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
91 EEF1A1suppressor670.2641659.048GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
92 EEF1A2oncoprotein210.36744.615GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
93 EEF1Dprotein found in more fusions330.327179.042EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
94 EGLN1suppressor50.5006.062zf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
95 EGLN3suppressor60.40024.3152OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
96 EIF4A3interactor350.374174.965DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
97 ENO3interactor80.6078.929Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
98 EP300oncoprotein340.188742.417Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
99 EPM2Ainteractor200CBM_20 (PF00686, IPR002044): Starch binding domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
100 ETS1oncoprotein60.5335.164Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
101 EWSR1oncoprotein440.301409.154RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
102 EXOSC5interactor60.133104.074RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
103 EZH2suppressor270.249246.368CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
104 FAM49Binteractor30.6672.791DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394)
105 FBXO6interactor430.220703.912FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
106 FGFR1oncoprotein70.13327.139I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
107 FHsuppressor170.33870.412Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
108 FHOD1interactor60.50019.992Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
109 FLNBoncoprotein210.414125.255CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
110 FMNL1protein found in more fusions90.35738.057CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
SlyX (PF04102, IPR007236): SlyX
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
111 FN1oncoprotein700.1891585.458fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
112 FUBP1oncoprotein240.29098.302DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
113 FUSsuppressor470.428225.828Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
114 GAPDHoncoprotein600.286681.265Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
115 GIT1interactor90.46435.416ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
116 GNG12interactor30.6670.907G-gamma (PF00631, IPR015898, SM00224): GGL domain
117 GRB7interactor30.3333.418BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
118 GRNoncoprotein110.25593.594Granulin (PF00396, IPR000118, SM00277): Granulin
Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
119 H2AFXsuppressor240.37093.739Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
120 HACE1suppressor31.0000HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
121 HDAC5protein found in more fusions340.286142.899Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
122 HDAC6oncoprotein290.222413.408Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
123 HERC1protein found in more fusions50.3334.435Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Presenilin (PF01080, IPR001108): Presenilin
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SPRY (PF00622, IPR003877, SM00449): SPRY domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
124 HIF1Asuppressor170.346104.883Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
125 HIST1H3Ainteractor200.170347.631Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
126 HLA-DRAinteractor70.57147.131MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
127 HLA-DRB1interactor90.67910.106DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
128 HLA-DRB3interactor50.7003.786DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
129 HLA-DRB4interactor40.5003.786DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
130 HLA-DRB5interactor60.8003.786MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
131 HNRNPA1interactor610.367665.941RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
132 HNRNPDoncoprotein430.319474.161CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
133 HNRNPKoncoprotein490.332479.300ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
134 HPS4interactor100NA
135 HSP90AA1oncoprotein780.1992242.567HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
136 HSP90AB1oncoprotein660.260999.760HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
137 HSPB1oncoprotein420.300416.500HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
138 HUWE1oncoprotein440.296325.850BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
139 IGBP1interactor110.218110.269TAP42 (PF04177, IPR007304): TAP42-like family
140 IGSF8oncoprotein170.36034.430V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
141 IKBKAPinteractor80.33320.832IKI3 (PF04762, IPR006849): IKI3 family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
142 IL1RAPinteractor40.5004.403ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
143 IPO11interactor80.50010.808DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
144 IQCB1interactor200.342137.731DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
145 IQGAP1interactor360.356433.761CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
146 IQGAP2suppressor208.269CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
147 IQGAP3interactor3022.307CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
SHD1 (PF03983, IPR007131): SLA1 homology domain 1, SHD1
148 ISG15suppressor240.283103.656ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
149 ITGA4interactor570.268764.319FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
150 KALRNoncoprotein2017.777fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Spectrin (PF00435, IPR002017): Spectrin repeat
UPF0302 (PF08864, IPR014963): UPF0302 domain
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PH_10 (PF15411): Pleckstrin homology domain
SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
151 KPNA2interactor290.271499.334Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
152 KPNA4interactor80.39335.213Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
153 KPNA6interactor80.50049.883Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
154 KPNB1protein found in more fusions360.210492.972Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
155 KRT40interactor60.20053.679Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
156 KTN1oncoprotein50.40022.531ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
157 LATS1suppressor140.253165.369Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
158 LDHAinteractor390.356240.634Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
159 LDHAL6Ainteractor40.3334.473Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
160 LDHBinteractor290.368119.416Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
161 LGALS1interactor210.290186.538Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
162 LIMA1suppressor310.290382.858LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
163 LMNB1interactor160.39251.273Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
164 LMO7oncoprotein100.44427.056CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF2072 (PF09845, IPR018645): Zn-ribbon containing protein
AAA_23 (PF13476): AAA domain
DUF4757 (PF15949, IPR031865): Domain of unknown function (DUF4757)
165 LNX1interactor150.176226.049PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
166 LRRK2oncoprotein180.309168.788Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
167 LTBP3oncoprotein207.036EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TB (PF00683, IPR017878): TB domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
168 LTBP4interactor3020.429EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TB (PF00683, IPR017878): TB domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
169 LYPLA2interactor70.7142.245Abhydrolase_2 (PF02230, IPR003140): Phospholipase/Carboxylesterase
170 LZTS2suppressor100.22254.727CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
171 MAGI1interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_C58 (PF03543, IPR006473): Yersinia/Haemophilus virulence surface antigen
Serglycin (PF04360, IPR007455): Serglycin
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
PDZ_2 (PF13180, IPR001478): PDZ domain
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
DUF4770 (PF15994, IPR031935): Domain of unknown function (DUF4770)
MAGI_u1 (PF16663): Unstructured region on MAGI
MAGI_u5 (PF16666): Unstructured region on MAGI
172 MAP3K10interactor31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
173 MAP3K11interactor90.28694.728APG6 (PF04111, IPR007243): Autophagy protein Apg6
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
174 MAP3K4suppressor50.33324.998CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pkinase (PF00069, IPR000719): Protein kinase domain
PLU-1 (PF08429, IPR013637): PLU-1-like protein
Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958)
175 MAPK7oncoprotein140.42358.977Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
176 MCF2Linteractor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Spectrin (PF00435, IPR002017): Spectrin repeat
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4771 (PF15995, IPR031936): Domain of unknown function (DUF4771)
177 MCM2oncoprotein750.2701068.589AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
178 MCM3APinteractor205.705RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAC3_GANP (PF03399, IPR005062): SAC3/GANP family
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
CID_GANP (PF16766, IPR031910): Binding region of GANP to ENY2
NupH_GANP (PF16768, IPR031908): Nucleoporin homology of Germinal-centre associated nuclear protein
MCM3AP_GANP (PF16769, IPR031907): MCM3AP domain of GANP
179 MCM5oncoprotein330.392153.775MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
180 MDM2oncoprotein440.250669.163Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
181 ME1interactor30.3336.863malic (PF00390, IPR012301): Malic enzyme, N-terminal domain
Malic_M (PF03949, IPR012302, SM00919): Malic enzyme, NAD binding domain
182 MGMTinteractor120.53013.177DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
183 MPGinteractor40.6674.662Pur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG)
184 MTNR1Ainteractor2020.0427tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
185 MYD88oncoprotein70.26761.200Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
186 MYH9suppressor410.301699.577IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
187 MYOCinteractor100.6113.014IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
188 NAGKprotein found in more fusions40.6670.942BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
189 NANSinteractor110.45519.961NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
190 NCF2interactor2015.017PB1 (PF00564, IPR000270, SM00666): PB1 domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
TPR_16 (PF13432): Tetratricopeptide repeat
191 NCKAP1interactor50.50016.559Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein
192 NDRG1suppressor130.26949.793Ndr (PF03096, IPR004142): Ndr family
193 NEDD4suppressor180.279184.754Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
194 NLKprotein found in more fusions60.3008.081Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
195 NME1suppressor110.22290.185NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
196 NOS2interactor220.295252.862FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
197 NOXA1interactor30.33314.088PB1 (PF00564, IPR000270, SM00666): PB1 domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
198 NPLOC4interactor170.45655.307NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
199 NPM1suppressor660.2841042.727Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
200 NTRK1oncoprotein1170.1296475.762I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
201 NXT2interactor40.5006.113NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
202 OBSL1protein found in more fusions460.292315.684BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
203 OPHN1interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
BAR_3 (PF16746): BAR domain of APPL family
204 PAICSinteractor210.42659.325AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
205 PAK1oncoprotein140.231142.926PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
206 PAK2protein found in more fusions110.267112.223PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
207 PAK3interactor31.0000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
208 PAK4protein found in more fusions100.25067.107PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
209 PAK5interactor50.3338.501PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
210 PAK6interactor70.42940.048PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
211 PAN2interactor240.232221.945RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
212 PARD6Ainteractor40.6673.407PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
213 PARD6Binteractor80.25076.824PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
214 PARD6Ginteractor30.6670.667PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
215 PARK2suppressor310.320284.311IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
216 PAX8oncoprotein30.6670.926PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Pax2_C (PF12403, IPR022130): Paired-box protein 2 C terminal
217 PCBP1oncoprotein500.274592.198Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
218 PDLIM5interactor150.429120.948LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
219 PFKLprotein found in more fusions170.39276.564PFK (PF00365, IPR000023): Phosphofructokinase
220 PFKMprotein found in more fusions130.39447.622PFK (PF00365, IPR000023): Phosphofructokinase
221 PFKPinteractor210.381186.876PFK (PF00365, IPR000023): Phosphofructokinase
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
222 PGK1interactor340.444141.462PGK (PF00162, IPR001576): Phosphoglycerate kinase
223 PIAS3oncoprotein90.139133.755SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
224 PIN1suppressor210.219211.769Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
225 PLEKHG2oncoprotein202.740PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
226 PLIN3interactor160.41075.049Perilipin (PF03036, IPR004279): Perilipin family
227 PMLsuppressor190.35961.853zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
228 POLE2interactor21.0000DNA_pol_E_B (PF04042, IPR007185): DNA polymerase alpha/epsilon subunit B
Dpoe2NT (PF12213, IPR024639): DNA polymerases epsilon N terminal
229 PPIDinteractor110.67311.025Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
230 PPME1protein found in more fusions110.4228.509Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
231 PPP1CAsuppressor320.256316.321Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
232 PPP2CAsuppressor250.270224.618Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
233 PRDX2interactor270.353117.055AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
234 PRDX6protein found in more fusions210.295176.009AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
235 PRMT6interactor2020.333Methyltransf_25 (PF13649): Methyltransferase domain
236 PSAT1interactor150.343199.683Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
237 PSMA3interactor340.407152.791Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
238 PTENsuppressor210.162168.145DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
239 PTK2protein found in more fusions160.267209.522FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
240 RAB10oncoprotein110.436122.578Ras (PF00071, IPR001806, SM00173): Ras family
241 RAB2Aoncoprotein70.28659.249Ras (PF00071, IPR001806, SM00173): Ras family
242 RAD23Bsuppressor220.268168.877K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
243 RAF1oncoprotein200.216178.318Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
244 RALBP1interactor30.3335.330DDHD (PF02862, IPR004177, SM01127): DDHD domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SlyX (PF04102, IPR007236): SlyX
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
Nod1 (PF17114, IPR032634): Gef2-related medial cortical node protein Nod1
245 RAP1Boncoprotein80.214108.183Ras (PF00071, IPR001806, SM00173): Ras family
246 RAP1GDS1oncoprotein50.50017.998Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
247 RBMXsuppressor250.457154.216RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
248 RCC1interactor130.34638.973RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
249 RCC2oncoprotein120.40943.868RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
250 RELAoncoprotein260.247441.921DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
251 RELBoncoprotein70.33350.232RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
RelB_leu_zip (PF16180, IPR032399): RelB leucine zipper
RelB_transactiv (PF16181, IPR032400): RelB transactivation domain
252 RGL2interactor30.33318.139RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
253 RHOBsuppressor40.33312.271Ras (PF00071, IPR001806, SM00173): Ras family
254 RHOConcoprotein90.19489.219Ras (PF00071, IPR001806, SM00173): Ras family
255 RNF185interactor60.4005.091zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
256 RPL3interactor270.382171.292Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
257 RPN1oncoprotein180.35381.657Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
258 RPP14interactor100RNase_P_Rpp14 (PF01900, IPR002759): Rpp14/Pop5 family
259 SEToncoprotein220.229323.972NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
260 SFPQoncoprotein350.275398.876GRP (PF07172, IPR010800): Glycine rich protein family
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
261 SH3RF1protein found in more fusions40.6670.523zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
262 SH3RF2interactor80.21466.736SH3_2 (PF07653, IPR011511): Variant SH3 domain
TUDOR (PF00567, IPR002999, SM00333): Tudor domain
UPF0547 (PF10571, IPR018886): Uncharacterised protein family UPF0547
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
SH3_9 (PF14604, IPR001452): Variant SH3 domain
263 SH3RF3interactor21.0000SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
264 SHBGoncoprotein40.6670.616Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
265 SLC3A2interactor120.51511.479Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain
DUF3459 (PF11941, IPR022567): Domain of unknown function (DUF3459)
SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus
266 SMN1interactor200.29888.866SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
267 SRP14interactor170.33146.497SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
268 STAT3suppressor160.210310.804SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
269 STAU1protein found in more fusions360.385109.097dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
270 SUMO1interactor150.37444.076Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
271 SUZ12suppressor250.239178.639DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
272 SYNJ2interactor100DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
Syja_N (PF02383, IPR002013): SacI homology domain
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
273 TALDO1interactor190.368323.178TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
274 TECinteractor30.6671.636BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
275 TERF1interactor330.220354.921TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
276 TIAM1oncoprotein30.6671.029PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
AAA_22 (PF13401, IPR003593): AAA domain
277 TINF2interactor110.4009.780TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
278 TK1oncoprotein130.36444.255TK (PF00265, IPR001267, SM00203): Thymidine kinase
279 TKTprotein found in more fusions380.317278.787Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
280 TNFoncoprotein100.30649.820TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
281 TOLLIPinteractor100.30679.800C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
282 TOM1oncoprotein100.333115.173GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
283 TOP2Aoncoprotein130.23166.512DNA_gyraseB (PF00204, IPR013506): DNA gyrase B
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Toprim (PF01751, IPR006171, SM00493): Toprim domain
DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
284 TRAF3IP1interactor100.5116.356MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
285 TRAP1oncoprotein220.36869.945HSP90 (PF00183, IPR001404): Hsp90 protein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
286 TRIM35suppressor21.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410)
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
287 TRIM63interactor80.33327.021DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
KIP1 (PF07765, IPR011684): KIP1-like protein
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
288 TRIOoncoprotein201.403T3SS_needle_E (PF08988, IPR012671): Type III secretion system, cytoplasmic E component of needle
GRP (PF07172, IPR010800): Glycine rich protein family
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pap_E4 (PF02711, IPR003861): E4 protein
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Spectrin (PF00435, IPR002017): Spectrin repeat
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
PH_10 (PF15411): Pleckstrin homology domain
SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
289 TUBA4Ainteractor240.37360.620Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
290 TUBBinteractor450.294472.584Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
291 TWF2interactor60.4008.936Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
292 U2AF2protein found in more fusions510.318478.907RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
293 UBA2interactor140.451108.794ThiF (PF00899, IPR000594): ThiF family
UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
294 UBCprotein found in more fusions570.2191465.481ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
295 UCHL5oncoprotein190.29498.871Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
296 UFM1interactor110.20054.365Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
297 UNKLinteractor100Mnd1 (PF03962, IPR005647): Mnd1 family
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
298 USH1Cprotein found in more fusions200CemA (PF03040, IPR004282): CemA family
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Saw1 (PF11561, IPR021624): Single strand annealing-weakened 1
DUF3393 (PF11873, IPR024570): Domain of unknown function (DUF3393)
DUF3567 (PF12091, IPR021951): Protein of unknown function (DUF3567)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
299 USP6oncoprotein202.740RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
300 USP7oncoprotein300.249278.427MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
301 VAV1oncoprotein110.164149.012PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
302 VAV3oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
DUF2326 (PF10088, IPR018760): Uncharacterised protein conserved in bacteria (DUF2326)
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
PH_10 (PF15411): Pleckstrin homology domain
303 VCAM1interactor530.234610.884C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
304 VCPprotein found in more fusions680.2401338.696AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
305 VWFinteractor100Antistasin (PF02822, IPR004094): Antistasin family
C8 (PF08742, IPR014853, SM00832): C8 domain
Metallothio_5 (PF02067, IPR000966): Metallothionein family 5
Pacifastin_I (PF05375, IPR008037): Pacifastin inhibitor (LCMII)
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
VWA_N2 (PF16164, IPR032361): VWA N-terminal
306 WASoncoprotein40.16742.986CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
307 WASF1interactor40.6676.039Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
WH2 (PF02205, IPR003124, SM00246): WH2 motif
308 XIAPinteractor120.255106.365BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
309 YWHAQinteractor560.284773.65614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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