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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RABEP1 (from a repository: Sat Nov 12 09:32:27 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins16 (36.36 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)112 (11.84 %)
The number (and %) of affected PPIs44 (39.29 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI4.364
Assortativity coefficient-0.2535
The network average Clustering coefficient0.526
The number (and %) of a zero Clustering coefficients12 (27.27 %)
The number (and %) of a zero Betweenness Centrality24 (54.55 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RABEP1 All fusions
: Z28809;
Proteins found in more fusions CCND1 (see 1 fusions); ITSN2 (see 1 fusions); RABEP1 (see 1 fusions); OFD1 (see 1 fusions); TRIM26 (see 1 fusions); SRPK2 (see 1 fusions); UBC (see 1 fusions); YWHAG (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RABEP1parental protein440.0591521.333Fib_succ_major (PF09603, IPR011871): Fibrobacter succinogenes major domain (Fib_succ_major)
Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
Rabaptin (PF03528, IPR018514): Rabaptin
2 ACTR10interactor31.0000Actin (PF00022, IPR004000, SM00268): Actin
3 ACTR1Binteractor31.0000Actin (PF00022, IPR004000, SM00268): Actin
4 AP1G1interactor30.6670.500Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
5 AP1G2interactor100Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
6 ATXN7interactor100DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
7 CCDC183interactor30.6670.500MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
8 CCND1oncoprotein200Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
9 CSNK2A2interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
10 DCTN2interactor60.6004.000Dynamitin (PF04912): Dynamitin
11 EEA1interactor41.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
Filament (PF00038, IPR001664): Intermediate filament protein
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
IncA (PF04156, IPR007285): IncA protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
12 GAP43interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Neuromodulin (PF06614, IPR017454): Neuromodulin
Neuromodulin_N (PF10580, IPR018947): Gap junction protein N-terminal region
13 GGA1oncoprotein70.5335.667Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
GAT (PF03127, IPR004152): GAT domain
Hormone_3 (PF00159, IPR001955): Pancreatic hormone peptide
VHS (PF00790, IPR002014, SM00288): VHS domain
AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal
14 GGA2interactor31.0000Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
15 GGA3interactor40.8330.667Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
16 HERC2interactor40.6670.500ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
17 HSF4interactor100Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
18 HSFY1interactor100HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
19 HUNKinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
20 ITSN1interactor40.6670.667C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
21 ITSN2protein found in more fusions40.6670.667C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
22 KIAA0368interactor30.6671.000HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
23 NCAPD2oncoprotein21.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
HEAT (PF02985, IPR000357): HEAT repeat
LrgA (PF03788, IPR005538): LrgA family
Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
24 NTRK1oncoprotein160.21975.500I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
25 OFD1protein found in more fusions40.6670.667APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
26 PLEConcoprotein100CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
S10_plectin (PF03501, IPR005326): Plectin/S10 domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229)
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
YlqD (PF11068, IPR021297): YlqD protein
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
27 RAB1Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
28 RAB33Boncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
29 RAB4Aoncoprotein40.8330.500Ras (PF00071, IPR001806, SM00173): Ras family
30 RAB5Aoncoprotein90.30622.500Ras (PF00071, IPR001806, SM00173): Ras family
31 RABEP2interactor50.6002.667Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
Rabaptin (PF03528, IPR018514): Rabaptin
32 RABGEF1interactor100.36120.167Rho_Binding (PF08912, IPR015008): Rho Binding
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
SSTK-IP (PF15836, IPR031679): SSTK-interacting protein, TSSK6-activating co-chaperone protein
33 RGS17interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
34 RUFY1interactor70.4007.167DM (PF00751, IPR001275, SM00301): DM DNA binding domain
FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RUN (PF02759, IPR004012, SM00593): RUN domain
Tektin (PF03148, IPR000435): Tektin family
35 SGTBinteractor21.0000TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_11 (PF13414, IPR011990): TPR repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
36 SLMAPinteractor30.6670.667Fez1 (PF06818): Fez1
FHA (PF00498, IPR000253, SM00240): FHA domain
Spectrin (PF00435, IPR002017): Spectrin repeat
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
37 SMU1interactor100LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
38 SRPK2oncoprotein31.0000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
39 TRIM26protein found in more fusions31.0000Nop14 (PF04147, IPR007276): Nop14-like family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
40 UACAinteractor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
DivIC (PF04977, IPR007060): Septum formation initiator
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
MAD (PF05557, IPR008672): Mitotic checkpoint protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
SHE3 (PF17078, IPR031398): SWI5-dependent HO expression protein 3
41 UBCprotein found in more fusions120.32732.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
42 YWHAEoncoprotein41.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
43 YWHAGprotein found in more fusions70.7332.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
44 YWHAQinteractor41.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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