Find Fusion Network

Enter
Fusion ID:
Protein names:

Level of PPIs:
or Upload text file: 		Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SERPINA1, RAB38 (from a repository: Wed Jan 20 19:09:18 2021)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges
Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins10 (29.41 %)
The number (and %) of the tumor suppressors3 (8.82 %)
Total number of binary PPIs (saturation %)70 (12.48 %)
The number (and %) of affected PPIs32 (45.71 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI3.529
Assortativity coefficient-0.3545
The network average Clustering coefficient0.325
The number (and %) of a zero Clustering coefficients18 (52.94 %)
The number (and %) of a zero Betweenness Centrality18 (52.94 %)

ACTIVE INTERACTORS


List of the fusions
PPI for parental proteins: RAB38,SERPINA1 All fusions
Proteins found in more fusions VCP (see 4 fusions); SDC2 (see 2 fusions); APP (see 4 fusions); ECHS1 (see 1 fusions); OS9 (see 2 fusions); SMAD4 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam, InterPro, SMART): description
1 RAB38parental protein2064.000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
Ras (PF00071, IPR001806, SM00173): Ras family
2 SERPINA1parental protein300.051873.690Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
3 ALDH2oncoprotein2019.560Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
4 APPprotein found in more fusions80139.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATP5C1interactor40.33336.131ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
6 CA8interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
7 CANXinteractor21.0000Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
8 DDX19Binteractor2019.560DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
9 DERL1interactor50.50036.298DER1 (PF04511, IPR007599): Der1-like family
10 DERL2interactor50.7003.774DER1 (PF04511, IPR007599): Der1-like family
11 ECHS1protein found in more fusions200ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
12 ELANEinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
13 ERLEC1interactor40.8330.500PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
14 FBXO2interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain
15 FN1oncoprotein70.38115.571fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
16 GDPD1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
17 GSDMBinteractor2019.560Gasdermin (PF04598, IPR007677): Gasdermin family
18 HSPA5oncoprotein90.39315.500HSP70 (PF00012, IPR013126): Hsp70 protein
19 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
20 KLK3interactor31.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
21 LAMTOR5interactor21.0000LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
22 MIS12interactor100DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
23 OS9protein found in more fusions60.8001.000DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
24 PLK2suppressor2019.560Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
25 PRTN3interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
26 RAB32oncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
27 RAP2Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
28 RCHY1suppressor200C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
29 SDC2protein found in more fusions31.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
30 SMAD4suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
31 SSR1interactor30.6671.333TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
32 VCPprotein found in more fusions90.39318.964AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
33 VKORC1interactor200VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
34 ZNF558interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

B a c k    t o    T o p ⇑