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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RAB11FIP2 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins11 (35.48 %)
The number (and %) of the tumor suppressors2 (6.45 %)
Total number of binary PPIs (saturation %)91 (19.57 %)
The number (and %) of affected PPIs31 (34.07 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI4.903
Assortativity coefficient-0.3963
The network average Clustering coefficient0.610
The number (and %) of a zero Clustering coefficients6 (19.35 %)
The number (and %) of a zero Betweenness Centrality13 (41.94 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RAB11FIP2 All fusions
: BF798700;
Proteins found in more fusions REPS1 (see 1 fusions); EPS15 (see 1 fusions); RAB11FIP2 (see 1 fusions); YWHAZ (see 1 fusions); RAB11FIP1 (see 2 fusions); MARK2 (see 2 fusions); YWHAG (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RAB11FIP2parental protein310.106701.767C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
2 AK1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ADK (PF00406, IPR000850): Adenylate kinase
3 AP2A1interactor30.6671.000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
4 ASAP1interactor21.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
BAR_3 (PF16746): BAR domain of APPL family
5 ATP6AP2interactor31.0000Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
6 BAIAP2interactor70.8670.833IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
7 CLCN2interactor100CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
8 CXCR2suppressor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
9 EHD1interactor50.5003.000Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
10 EHD3suppressor31.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
11 EPS15oncoprotein40.6671.000Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
12 GJB2interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
13 ITSN1interactor40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
14 JAK3oncoprotein21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
15 KIF21Ainteractor100DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Strep_SA_rep (PF06696, IPR009578): Streptococcal surface antigen repeat
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
16 KIF7interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
MMR_HSR1_C (PF08438, IPR013646): GTPase of unknown function C-terminal
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
XhlA (PF10779, IPR019715): Haemolysin XhlA
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
YlqD (PF11068, IPR021297): YlqD protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
17 KLC1interactor60.8670.833Gly_radical (PF01228, IPR001150): Glycine radical
SOGA (PF11365, IPR027881): Protein SOGA
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
18 MARK2protein found in more fusions70.9330.400DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
19 MKNK2interactor100ABC_trans_aux (PF03886, IPR005586): ABC-type transport auxiliary lipoprotein component
Pkinase (PF00069, IPR000719): Protein kinase domain
20 MYO5Binteractor50.6003.4005_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DIL (PF01843, IPR018444, SM01132): DIL domain
Fez1 (PF06818): Fez1
HalX (PF08663, IPR013971): HalX domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF3251 (PF11622, IPR021658): Protein of unknown function (DUF3251)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
21 RAB11Aoncoprotein100.28929.500Ras (PF00071, IPR001806, SM00173): Ras family
22 RAB11Boncoprotein60.7331.900Ras (PF00071, IPR001806, SM00173): Ras family
23 RAB11FIP1protein found in more fusions100.41718.467C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
SOUL (PF04832, IPR006917): SOUL heme-binding protein
Latarcin (PF10279, IPR018802): Latarcin precursor
24 RAB11FIP4interactor41.0000HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
RBD-FIP (PF09457, IPR019018): FIP domain
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
Leu_zip (PF15294): Leucine zipper
25 RAB11FIP5interactor60.7002.067C2 (PF00168, IPR000008, SM00239): C2 domain
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
RBD-FIP (PF09457, IPR019018): FIP domain
26 RAB25oncoprotein50.7001.500Ras (PF00071, IPR001806, SM00173): Ras family
27 REPS1protein found in more fusions31.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
MCLC (PF05934, IPR009231): Mid-1-related chloride channel (MCLC)
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
28 YWHABinteractor80.7862.53314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
29 YWHAEoncoprotein80.7862.53314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
30 YWHAGprotein found in more fusions90.6795.86714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
31 YWHAZprotein found in more fusions70.9330.40014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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