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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RAB11FIP1 (from a repository: Tue Dec 6 00:20:15 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins9 (42.86 %)
The number (and %) of the tumor suppressors2 (9.52 %)
Total number of binary PPIs (saturation %)49 (23.33 %)
The number (and %) of affected PPIs21 (42.86 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI4.000
Assortativity coefficient-0.2472
The network average Clustering coefficient0.543
The number (and %) of a zero Clustering coefficients6 (28.57 %)
The number (and %) of a zero Betweenness Centrality13 (61.90 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RAB11FIP1 All fusions
: CA314282; BU680326;
Proteins found in more fusions RAB11FIP1 (see 2 fusions); CTBP2 (see 2 fusions); RAB11FIP2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RAB11FIP1parental protein210.116293.833C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
SOUL (PF04832, IPR006917): SOUL heme-binding protein
Latarcin (PF10279, IPR018802): Latarcin precursor
2 ASAP1interactor21.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
BAR_3 (PF16746): BAR domain of APPL family
3 BAIAP2interactor51.0000IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
4 CTBP2protein found in more fusions2002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
5 DYNLT1interactor100Tctex-1 (PF03645, IPR005334): Tctex-1 family
6 FAM217Binteractor21.0000FAM217 (PF15344, IPR029266): FAM217 family
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
7 FGFR1OPoncoprotein40.6670.667FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
8 IKBKGinteractor31.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
9 KLC1interactor60.6005.000Gly_radical (PF01228, IPR001150): Glycine radical
SOGA (PF11365, IPR027881): Protein SOGA
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
10 PDGFRAoncoprotein200Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
11 RAB11Aoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
12 RAB11Boncoprotein60.4677.667Ras (PF00071, IPR001806, SM00173): Ras family
13 RAB11FIP2protein found in more fusions100.41720.167C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
14 RAB14oncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
15 RAB25suppressor31.0000Ras (PF00071, IPR001806, SM00173): Ras family
16 RAB4Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
17 RASSF8suppressor31.0000ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
FliD_C (PF07195, IPR010809): Flagellar hook-associated protein 2 C-terminus
PEARLI-4 (PF05278, IPR007942): Arabidopsis phospholipase-like protein (PEARLI 4)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
18 RELTinteractor100Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
RELT (PF12606, IPR022248): Tumour necrosis factor receptor superfamily member 19
19 XPO1interactor30.6670.667CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
20 YWHABinteractor50.9000.50014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
21 YWHAEoncoprotein70.5717.50014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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