Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins QKI (from a repository: Sun Dec 4 14:05:24 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 61 The number (and %) of the onco-proteins 23 (37.70 %) The number (and %) of the tumor suppressors 2 (3.28 %) Total number of binary PPIs (saturation %) 349 (19.07 %) The number (and %) of affected PPIs 61 (17.48 %) The number of possible different fusions 16 PPI diameter 2 PPI radius 1 The average degree of PPI 10.557 Assortativity coefficient -0.2237 The network average Clustering coefficient 0.619 The number (and %) of a zero Clustering coefficients 5 (8.20 %) The number (and %) of a zero Betweenness Centrality 13 (21.31 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: QKI	All fusions : BF348123; CD109394;
Proteins found in more fusions	EWSR1/MED15 (see 3 fusions); PTBP1 (see 1 fusions); RBMX (see 3 fusions); RBFOX2 (see 2 fusions); EWSR1 (see 2 fusions); APP (see 4 fusions); PCBP2 (see 3 fusions); HNRNPLL (see 1 fusions); U2AF2 (see 2 fusions); POLR2A (see 2 fusions); QKI (see 3 fusions); WDR77 (see 1 fusions); ATXN1 (see 3 fusions); USH1C (see 1 fusions); RBPMS (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	QKI	parental protein	61	0.148	2262.110	KH_1 (PF00013, IPR004088, SM00322): KH domain STAR_dimer (PF16544, IPR032377): Homodimerisation region of STAR domain protein Quaking_NLS (PF16551, IPR032367): Putative nuclear localisation signal of quaking
2	APP	protein found in more fusions	9	0.357	14.667	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3	ATXN1	protein found in more fusions	9	0.429	11.567	AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH) Spt20 (PF12090, IPR021950): Spt20 family ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
4	C10orf10	interactor	1	0	0	DEPP (PF15343, IPR020133): Decidual protein induced by progesterone family
5	CARM1	oncoprotein	4	1.000	0	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
6	CDV3	interactor	5	0.700	3.000	TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3
7	CYP1A1	oncoprotein	2	1.000	0	p450 (PF00067, IPR001128): Cytochrome P450
8	DAZ1	interactor	2	0	0	DUF1970 (PF09301, IPR015380): Domain of unknown function (DUF1970) Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WRC (PF08879, IPR014977): WRC DUF2582 (PF10771, IPR019707): Winged helix-turn-helix domain (DUF2582) DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
9	ELAVL1	oncoprotein	22	0.329	97.233	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10	EWSR1	oncoprotein	14	0.449	28.108	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
11	FN1	oncoprotein	13	0.513	17.579	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
12	FUBP3	interactor	7	0.571	5.567	DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897) KH_1 (PF00013, IPR004088, SM00322): KH domain
13	HCLS1	interactor	2	1.000	0	HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) TMEM210 (PF15195, IPR028123): TMEM210 family SPESP1 (PF15754, IPR026743): Sperm equatorial segment protein 1
14	HNRNPH2	interactor	6	0.800	0.733	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
15	HNRNPK	oncoprotein	16	0.552	22.483	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
16	HNRNPLL	protein found in more fusions	8	0.476	6.400	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1 RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
17	IL7R	interactor	6	0.800	0.718	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
18	MED1	interactor	21	0.695	23.037	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
19	MED10	interactor	17	0.860	4.821	Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
20	MED12	oncoprotein	17	0.860	4.940	Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12 Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877) Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
21	MED13	oncoprotein	15	0.990	0.143	Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
22	MED14	interactor	16	0.917	2.440	Med14 (PF08638, IPR013947): Mediator complex subunit MED14
23	MED15	protein found in more fusions	17	0.794	19.614	Med15 (PF09606, IPR019087): ARC105 or Med15 subunit of Mediator complex non-fungal
24	MED16	interactor	17	0.831	10.440	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Med16 (PF11635, IPR021665): Mediator complex subunit 16
25	MED17	oncoprotein	16	0.917	2.440	Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
26	MED23	interactor	20	0.700	22.052	Med23 (PF11573, IPR021629): Mediator complex subunit 23
27	MED24	interactor	16	0.875	13.810	Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
28	MED25	interactor	15	1.000	0	Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2 Med25_SD1 (PF11235, IPR021397): Mediator complex subunit 25 synapsin 1 Med25_NR-box (PF11244, IPR021406): Mediator complex subunit 25 C-terminal NR box-containing Med25_VWA (PF11265, IPR021419): Mediator complex subunit 25 von Willebrand factor type A
29	MED26	interactor	18	0.791	10.460	Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
30	MED27	interactor	14	1.000	0	Med27 (PF11571, IPR021627): Mediator complex subunit 27
31	MED29	interactor	19	0.771	20.821	Med29 (PF11568, IPR021018): Mediator complex subunit 29
32	MED31	interactor	9	0.806	7.000	Med31 (PF05669, IPR008831): SOH1
33	MED4	interactor	21	0.619	43.293	Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
34	NABP1	interactor	4	0.667	0.750	tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
35	NDUFA7	interactor	2	1.000	0	CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
36	NTRK1	oncoprotein	25	0.330	123.837	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
37	OIP5	interactor	2	1.000	0	Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
38	PCBP1	oncoprotein	16	0.467	41.499	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
39	PCBP2	protein found in more fusions	11	0.711	6.882	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
40	PCBP4	interactor	4	0.500	2.500	KH_1 (PF00013, IPR004088, SM00322): KH domain
41	POLR2A	protein found in more fusions	13	0.606	14.142	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
42	PSMF1	interactor	6	0.500	4.333	PI31_Prot_C (PF08577, IPR013886): PI31 proteasome regulator PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
43	PTBP1	oncoprotein	13	0.652	10.690	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
44	PTBP2	interactor	4	0.667	0.182	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
45	RALY	interactor	9	0.639	7.075	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
46	RBFOX1	interactor	7	0.600	5.333	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
47	RBFOX2	protein found in more fusions	13	0.409	31.233	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
48	RBM11	interactor	4	0.667	1.167	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
49	RBM14	suppressor	7	0.667	3.432	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
50	RBM23	interactor	3	0.667	1.000	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein RSRP (PF17069): Arginine/Serine-Rich protein 1
51	RBMX	suppressor	13	0.439	23.975	RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
52	RBPMS	protein found in more fusions	8	0.476	8.133	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
53	RNF138	interactor	4	0.500	1.833	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding DUF393 (PF04134, IPR007263): Protein of unknown function, DUF393 Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
54	SERF2	interactor	3	0.667	0.667	4F5 (PF04419, IPR007513): 4F5 protein family
55	SNRPA	interactor	13	0.606	12.417	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
56	THAP1	interactor	6	0.400	4.167	THAP (PF05485, IPR006612, SM00980): THAP domain Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
57	U2AF2	protein found in more fusions	18	0.404	55.279	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
58	USH1C	protein found in more fusions	2	0	0	CemA (PF03040, IPR004282): CemA family PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) Saw1 (PF11561, IPR021624): Single strand annealing-weakened 1 DUF3393 (PF11873, IPR024570): Domain of unknown function (DUF3393) DUF3567 (PF12091, IPR021951): Protein of unknown function (DUF3567) PRIMA1 (PF16101): Proline-rich membrane anchor 1
59	USP30	interactor	1	0	0	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
60	WDR77	oncoprotein	4	1.000	0	LT-IIB (PF06453, IPR010503): Type II heat-labile enterotoxin , B subunit (LT-IIB) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
61	ZACN	interactor	1	0	0	Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

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