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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PYGB (from a repository: Sun Dec 4 20:07:31 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins8 (20.51 %)
The number (and %) of the tumor suppressors5 (12.82 %)
Total number of binary PPIs (saturation %)110 (14.84 %)
The number (and %) of affected PPIs39 (35.45 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI5.077
Assortativity coefficient-0.3724
The network average Clustering coefficient0.568
The number (and %) of a zero Clustering coefficients7 (17.95 %)
The number (and %) of a zero Betweenness Centrality16 (41.03 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PYGB All fusions
Proteins found in more fusions PFKL (see 2 fusions); ACTN1 (see 3 fusions); PYGB (see 1 fusions); MCM2 (see 1 fusions); SKI (see 1 fusions); SIAH1 (see 4 fusions); NPM1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PYGBparental protein390.0871064.767Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
2 ACLYinteractor50.7001.400ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain
CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
Citrate_bind (PF16114, IPR032263): ATP citrate lyase citrate-binding
3 ACTN1protein found in more fusions60.8000.733CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
4 ARL6IP6interactor100DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix
5 ARMT1interactor21.0000DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
6 CAND1interactor60.9000.400Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7 CCNL2interactor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
8 CPNE1interactor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
9 CYP1A1oncoprotein21.0000p450 (PF00067, IPR001128): Cytochrome P450
10 FHsuppressor60.5336.000Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
11 FSD1interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
DUF4945 (PF16303, IPR032544): Domain of unknown function (DUF4945)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
12 GBE1interactor21.0000Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain
CBM_48 (PF02922, IPR004193): Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
Alpha-amylase_C (PF02806, IPR006048, SM00632): Alpha amylase, C-terminal all-beta domain
13 HSD17B3interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
14 LIMD1suppressor50.6671.333LIM (PF00412, IPR001781, SM00132): LIM domain
15 LIN37interactor100LIN37 (PF15306, IPR028226): LIN37
16 MCM2oncoprotein120.36428.967AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
17 MCM5oncoprotein70.6673.133MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
18 MLH1suppressor30.6670.500DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
19 NAXEinteractor21.0000YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
20 NPM1suppressor90.46410.300Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
21 NTF3interactor30.6670.333NGF (PF00243, IPR002072, SM00140): Nerve growth factor family
22 NTRK1oncoprotein180.21397.700I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
23 OGFOD1interactor50.6003.000Ofd1_CTDD (PF10637, IPR019601): Oxoglutarate and iron-dependent oxygenase degradation C-term
2OG-FeII_Oxy_4 (PF13661): 2OG-Fe(II) oxygenase superfamily
24 PFKLprotein found in more fusions40.6670.333PFK (PF00365, IPR000023): Phosphofructokinase
25 PLCG1oncoprotein70.4769.833C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
26 PSMB2interactor21.0000Proteasome (PF00227, IPR001353): Proteasome subunit
27 PYGLinteractor120.27335.233Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
28 RIC8Ainteractor40.8330.500PUL (PF08324, IPR013535): PUL domain
Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
29 SENP3interactor50.7001.233Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
30 SIAH1suppressor41.0000Sina (PF03145, IPR018121): Seven in absentia protein family
31 SIRT7interactor70.4297.633DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
32 SKIoncoprotein200c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
33 STBD1interactor100CBM_20 (PF00686, IPR002044): Starch binding domain
34 TMEM185Ainteractor100Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
35 UBA6interactor50.5004.000ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
36 UBR7interactor50.6003.667PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
37 WDR61interactor40.6671.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
38 XPNPEP1interactor40.6671.667Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24
Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain
39 ZFP41interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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