Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PUF60 (from a repository: Wed Nov 16 07:30:56 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 123 The number (and %) of the onco-proteins 39 (31.71 %) The number (and %) of the tumor suppressors 17 (13.82 %) Total number of binary PPIs (saturation %) 1089 (14.51 %) The number (and %) of affected PPIs 123 (11.29 %) The number of possible different fusions 30 PPI diameter 2 PPI radius 1 The average degree of PPI 16.911 Assortativity coefficient -0.2316 The network average Clustering coefficient 0.501 The number (and %) of a zero Clustering coefficients 5 (4.07 %) The number (and %) of a zero Betweenness Centrality 11 (8.94 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PUF60	All fusions : CR978549;
Proteins found in more fusions	ID3 (see 1 fusions); U2AF2 (see 2 fusions); HNRNPH3 (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); EWSR1 (see 2 fusions); AIMP2 (see 1 fusions); COPS5 (see 1 fusions); FN1/YWHAG (see 1 fusions); PRPF40A (see 2 fusions); SNW1 (see 1 fusions); UGP2 (see 1 fusions); SREK1 (see 4 fusions); ILK (see 1 fusions); ABCC1 (see 1 fusions); G3BP1 (see 1 fusions); YWHAG (see 1 fusions); PUF60 (see 2 fusions); PABPC1 (see 2 fusions); COPS5/HNRNPH3 (see 3 fusions); SIAH1 (see 1 fusions); FAF1 (see 2 fusions); HNRNPL (see 2 fusions); STOM (see 1 fusions); MCM2 (see 1 fusions); CHD3 (see 1 fusions); HNRNPC (see 1 fusions); FN1/RPL6 (see 1 fusions); DDB1 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PUF60	parental protein	123	0.124	7147.185	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Titin_Z (PF09042, IPR015129): Titin Z TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
2	ABCC1	oncoprotein	5	1.000	0	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain ABC_ATPase (PF09818, IPR019195): Predicted ATPase of the ABC class DUF2304 (PF10066, IPR019277): Uncharacterized conserved protein (DUF2304) DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
3	AIMP2	suppressor	8	0.524	4.309	GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
4	ARGLU1	interactor	9	0.464	2.347	eIF3_subunit (PF08597, IPR013906): Translation initiation factor eIF3 subunit Kri1 (PF05178, IPR018034): KRI1-like family ARGLU (PF15346): Arginine and glutamate-rich 1
5	ARL8A	interactor	1	0	0	Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
6	AXIN1	suppressor	3	1.000	0	Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
7	BARD1	suppressor	18	0.324	38.181	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
8	BORCS5	interactor	1	0	0	LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
9	CACNA1A	interactor	1	0	0	Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain GRP (PF07172, IPR010800): Glycine rich protein family Ion_trans (PF00520, IPR005821): Ion transport protein Roughex (PF06020, IPR009259): Drosophila roughex protein SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
10	CAND1	interactor	50	0.344	245.573	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
11	CCNC	suppressor	4	0.667	1.667	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
12	CD2BP2	interactor	9	0.556	5.693	GYF (PF02213, IPR003169, SM00444): GYF domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
13	CDK2	suppressor	37	0.284	212.330	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
14	CDKN1A	suppressor	9	0.306	11.039	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
15	CHD3	oncoprotein	11	0.356	12.362	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) FAM176 (PF14851): FAM176 family
16	COPS5	protein found in more fusions	45	0.340	181.680	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
17	CPSF6	interactor	18	0.542	18.550	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1
18	CUL3	protein found in more fusions	54	0.286	363.263	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
19	CUL7	protein found in more fusions	47	0.272	238.331	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
20	DDB1	protein found in more fusions	18	0.397	35.789	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
21	DDX3X	suppressor	20	0.516	16.587	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
22	EED	suppressor	29	0.317	61.034	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
23	EEF1A1	suppressor	31	0.411	116.798	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
24	EIF4H	interactor	9	0.667	1.446	eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
25	ELAC2	oncoprotein	4	1.000	0	Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain Lactamase_B_4 (PF13691, IPR027794): tRNase Z endonuclease
26	ERG	oncoprotein	14	0.527	5.884	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
27	EWSR1	oncoprotein	37	0.329	173.519	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
28	FAF1	protein found in more fusions	11	0.533	11.950	UBX (PF00789, IPR001012, SM00166): UBX domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family AAA_11 (PF13086): AAA domain UBA_4 (PF14555): UBA-like domain
29	FAM129B	interactor	9	0.611	6.671	PH (PF00169, IPR001849, SM00233): PH domain
30	FBXW7	suppressor	9	0.393	9.974	Mem_trans (PF03547, IPR004776): Membrane transport protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 F-box-like (PF12937, IPR001810): F-box-like
31	FHL2	oncoprotein	6	0.500	3.167	LIM (PF00412, IPR001781, SM00132): LIM domain zf-ribbon_3 (PF13248): zinc-ribbon domain
32	FN1	oncoprotein	42	0.240	218.221	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
33	FOXK2	interactor	4	0.667	0.582	FHA (PF00498, IPR000253, SM00240): FHA domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
34	FOXL1	oncoprotein	4	0.500	1.900	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
35	FOXL2	suppressor	4	0.500	1.286	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
36	FOXQ1	interactor	4	0.667	0.508	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
37	G3BP1	protein found in more fusions	14	0.628	9.816	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
38	GPN1	interactor	3	1.000	0	ATP_bind_1 (PF03029, IPR004130): Conserved hypothetical ATP binding protein NB-ARC (PF00931, IPR002182): NB-ARC domain
39	H3F3A	oncoprotein	8	0.429	8.344	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
40	HDAC6	oncoprotein	9	0.429	8.795	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
41	HIRIP3	interactor	5	1.000	0	CHZ (PF09649, IPR019098, SM01082): Histone chaperone domain CHZ
42	HIST1H1C	oncoprotein	8	0.714	0.942	Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
43	HNRNPA1	interactor	48	0.387	222.942	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
44	HNRNPA3	oncoprotein	23	0.636	13.750	IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
45	HNRNPC	protein found in more fusions	30	0.424	74.693	APG6 (PF04111, IPR007243): Autophagy protein Apg6 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
46	HNRNPF	interactor	26	0.505	42.100	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
47	HNRNPH3	protein found in more fusions	19	0.654	7.498	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
48	HNRNPL	protein found in more fusions	22	0.595	33.385	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
49	HNRNPM	interactor	33	0.451	91.044	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
50	HSPD1	suppressor	21	0.476	22.300	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
51	ID3	oncoprotein	4	0.667	0.500	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
52	IGF2BP1	oncoprotein	15	0.505	19.764	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain MOEP19 (PF16005, IPR031952): KH-like RNA-binding domain
53	IGF2BP2	interactor	8	0.714	1.113	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain
54	IGF2BP3	interactor	17	0.610	12.548	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain
55	ILF2	interactor	33	0.462	88.480	DZF (PF07528, IPR006561, SM00572): DZF domain
56	ILK	suppressor	15	0.495	13.793	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
57	KHSRP	interactor	17	0.478	16.474	DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897) KH_1 (PF00013, IPR004088, SM00322): KH domain
58	KIAA0907	interactor	4	0.667	0.258	NA
59	KIAA1683	interactor	2	1.000	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
60	KLC4	interactor	4	0.667	0.554	Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat LUD_dom (PF02589): LUD domain
61	LAMTOR3	interactor	6	0.467	5.900	MAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
62	MATR3	interactor	29	0.516	61.227	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM60A (PF15396, IPR026065): Protein Family FAM60A
63	MCM2	oncoprotein	40	0.296	236.625	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
64	MED28	interactor	6	0.600	2.833	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain Med28 (PF11594, IPR021640): Mediator complex subunit 28
65	MOV10	interactor	34	0.203	297.191	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
66	MPV17	interactor	4	0.667	1.200	Mpv17_PMP22 (PF04117, IPR007248): Mpv17 / PMP22 family
67	MRM3	interactor	3	0.667	0.500	SpoU_methylase (PF00588, IPR001537): SpoU rRNA Methylase family SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding
68	MYO18A	interactor	3	0.667	0.133	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_tail_1 (PF01576, IPR002928): Myosin tail PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
69	NTRK1	oncoprotein	73	0.198	1101.785	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
70	NUDC	interactor	12	0.485	16.834	CS (PF04969, IPR007052): CS domain D5_N (PF08706, IPR014818, SM00885): D5 N terminal like Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc. NuDC (PF16273, IPR032572): Nuclear distribution C domain
71	OBSL1	interactor	38	0.377	85.557	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
72	OLA1	interactor	9	0.444	7.315	Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
73	P4HB	interactor	15	0.615	8.357	Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
74	PABPC1	oncoprotein	23	0.550	24.532	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
75	PABPC4	interactor	18	0.627	9.619	ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
76	PAPOLA	interactor	10	0.600	6.737	PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain Macoilin (PF09726, IPR019130): Transmembrane protein
77	PCBP1	oncoprotein	18	0.497	15.927	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
78	PPM1G	interactor	11	0.436	20.123	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) PP2C (PF00481, IPR001932): Protein phosphatase 2C DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
79	PPP1R16A	interactor	2	0	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
80	PRPF40A	protein found in more fusions	30	0.463	70.615	FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
81	PSMA3	interactor	14	0.397	15.690	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
82	PTBP2	interactor	5	0.667	0.287	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
83	QRICH1	interactor	5	0.667	1.167	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504) RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
84	RAB2A	oncoprotein	6	0.400	4.825	Ras (PF00071, IPR001806, SM00173): Ras family
85	RAD23B	suppressor	10	0.400	13.382	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
86	RAP1GDS1	oncoprotein	5	0.700	1.033	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1 V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H HEAT_2 (PF13646): HEAT repeats Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
87	RBM25	interactor	16	0.500	15.092	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 PWI (PF01480, IPR002483, SM00311): PWI domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 DUF3441 (PF11923, IPR021846): Domain of unknown function (DUF3441) U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4778 (PF16008, IPR031958): Domain of unknown function (DUF4778)
88	RNPS1	interactor	24	0.507	40.739	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) Macoilin (PF09726, IPR019130): Transmembrane protein
89	RPL6	protein found in more fusions	21	0.667	9.504	Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
90	SAP30BP	interactor	9	0.528	7.265	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HCNGP (PF07818, IPR012479): HCNGP-like protein Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
91	SARS2	interactor	6	0.867	0.536	tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) DUF2312 (PF10073, IPR018753): Uncharacterized protein conserved in bacteria (DUF2312) DUF4445 (PF14574, IPR027980): Domain of unknown function (DUF4445)
92	SDCBP	interactor	7	0.381	5.833	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
93	SF3A2	interactor	24	0.442	43.878	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
94	SF3A3	interactor	21	0.405	43.327	DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449) SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain Telomere_Sde2_2 (PF13297): Telomere stability C-terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
95	SF3B1	oncoprotein	27	0.427	90.933	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1 UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
96	SF3B6	interactor	13	0.603	5.879	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
97	SIAH1	suppressor	8	0.286	10.174	Sina (PF03145, IPR018121): Seven in absentia protein family
98	SIRT7	interactor	28	0.347	67.087	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
99	SNRPF	interactor	15	0.343	27.214	LSM (PF01423, IPR001163): LSM domain
100	SNW1	protein found in more fusions	35	0.396	113.729	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
101	SON	interactor	14	0.659	5.978	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region G-patch (PF01585, IPR000467, SM00443): G-patch domain tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1 GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer RSRP (PF17069): Arginine/Serine-Rich protein 1
102	SREK1	protein found in more fusions	15	0.429	10.206	Ureide_permease (PF07168, IPR009834): Ureide permease RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
103	SRRM1	interactor	21	0.562	19.456	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
104	SRRM2	interactor	40	0.449	116.166	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
105	SRSF11	interactor	18	0.503	25.403	Rtf2 (PF04641, IPR027799): Rtf2 RING-finger RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP2 (PF01254, IPR000678): Nuclear transition protein 2 Transformer (PF06495, IPR010519): Fruit fly transformer protein FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
106	SSB	interactor	14	0.527	12.064	HMA (PF00403, IPR006121): Heavy-metal-associated domain La (PF05383, IPR006630, SM00715): La domain Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 (PF08777, IPR014886): RNA binding motif
107	STOM	protein found in more fusions	6	0.500	3.400	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
108	SYNCRIP	interactor	26	0.597	23.206	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
109	TADA2A	interactor	15	0.362	27.383	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
110	TARS	interactor	13	0.462	16.111	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain TGS (PF02824, IPR004095): TGS domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
111	THRAP3	oncoprotein	17	0.390	39.300	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228) THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
112	TROVE2	interactor	8	0.714	4.019	TROVE (PF05731, IPR008858): TROVE domain DUF2201 (PF09967, IPR018698): VWA-like domain (DUF2201)
113	TTN	interactor	10	0.578	6.895	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
114	U2AF2	protein found in more fusions	47	0.414	183.292	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
115	UBE2I	interactor	12	0.436	16.339	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
116	UGP2	protein found in more fusions	15	0.440	29.776	UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
117	UPF2	interactor	4	0.667	0.100	DDHD (PF02862, IPR004177, SM01127): DDHD domain DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) MIF4G (PF02854, IPR003890, SM00543): MIF4G domain Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2 MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
118	VIM	suppressor	15	0.451	18.554	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
119	VPS29	interactor	5	0.700	2.167	Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
120	XPNPEP1	interactor	4	0.833	0.500	Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24 Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain
121	YWHAG	protein found in more fusions	19	0.464	24.801	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
122	ZG16	interactor	1	0	0	Jacalin (PF01419, IPR001229, SM00915): Jacalin-like lectin domain Beta-prism_lec (PF16458, IPR032496): Beta-prism lectin
123	ZYX	suppressor	11	0.436	13.381	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) LIM (PF00412, IPR001781, SM00132): LIM domain DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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