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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PTPRJ (from a repository: Mon Dec 5 22:21:52 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins9 (40.91 %)
The number (and %) of the tumor suppressors2 (9.09 %)
Total number of binary PPIs (saturation %)42 (18.18 %)
The number (and %) of affected PPIs22 (52.38 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.364
Assortativity coefficient-0.4195
The network average Clustering coefficient0.444
The number (and %) of a zero Clustering coefficients9 (40.91 %)
The number (and %) of a zero Betweenness Centrality15 (68.18 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PTPRJ All fusions
Proteins found in more fusions EGFR (see 2 fusions); TRIM25 (see 2 fusions); GRB2 (see 1 fusions); PTPRJ (see 2 fusions); LGALS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PTPRJparental protein220.076357.333fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Syndecan (PF01034, IPR027789): Syndecan domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
2 BAP1suppressor100Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
3 CASC3oncoprotein21.0000Btz (PF09405, IPR018545, SM01044): CASC3/Barentsz eIF4AIII binding
UPF0560 (PF10577, IPR018890): Uncharacterised protein family UPF0560
PRIMA1 (PF16101): Proline-rich membrane anchor 1
4 CTNNB1oncoprotein40.6671.667Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
5 CTNND1suppressor31.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
6 CYP17A1interactor100p450 (PF00067, IPR001128): Cytochrome P450
7 EGFRoncoprotein100.33323.667Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
8 EPSTI1interactor100TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
9 FBXO6interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
10 GRB2oncoprotein60.7003.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
11 HOXC6interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
12 KLK7oncoprotein100Trypsin (PF00089, IPR001254, SM00020): Trypsin
13 KLK9interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
14 LATinteractor41.0000LAT (PF15234, IPR008359): Linker for activation of T-cells
15 LGALS3oncoprotein40.6670.667Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
16 LGALS8interactor30.6671.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
17 LGALS9interactor30.6670.667Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
18 LYPD3oncoprotein100DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
19 PLCG1oncoprotein41.0000C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
20 PRDM14interactor100Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
21 SDCBPinteractor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
22 TRIM25protein found in more fusions200Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Pox_Rif (PF03340, IPR005008): Poxvirus rifampicin resistance protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4

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