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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)106
The number (and %) of the onco-proteins45 (42.45 %)
The number (and %) of the tumor suppressors16 (15.09 %)
Total number of binary PPIs (saturation %)538 (9.67 %)
The number (and %) of affected PPIs106 (19.70 %)
The number of possible different fusions20
PPI diameter2
PPI radius1
The average degree of PPI9.340
Assortativity coefficient-0.3217
The network average Clustering coefficient0.548
The number (and %) of a zero Clustering coefficients18 (16.98 %)
The number (and %) of a zero Betweenness Centrality33 (31.13 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PTPN11 All fusions
: AW362486;
Proteins found in more fusions PTPN11 (see 1 fusions); GAB2 (see 2 fusions); CBL (see 1 fusions); GSK3B (see 1 fusions); JAK2 (see 3 fusions); GRB2 (see 1 fusions); FYN (see 1 fusions); MAPK14 (see 1 fusions); ERBB3 (see 2 fusions); STAT3 (see 2 fusions); LGALS3 (see 2 fusions); TXNIP (see 2 fusions); PRLR (see 1 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); JAK1 (see 1 fusions); PTK2 (see 2 fusions); MAP3K5 (see 1 fusions); CBLB (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PTPN11parental protein1060.0717969.784SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
2 BCAR1oncoprotein110.6736.313Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
3 BTLAinteractor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
4 C6orf25interactor100G6B (PF15096, IPR028070): G6B family
5 CAV1suppressor80.5006.943Caveolin (PF01146, IPR001612): Caveolin
6 CBLsuppressor310.354153.075Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
7 CBLBoncoprotein160.63810.965Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 CD274oncoprotein100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
9 CD33interactor21.0000DUF998 (PF06197, IPR009339): Protein of unknown function (DUF998)
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
10 CD84interactor200I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Cadherin-like (PF12733, IPR025883): Cadherin-like beta sandwich domain
Ig_3 (PF13927): Immunoglobulin domain
11 CDC73suppressor80.8212.500CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
12 CDH5suppressor31.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
13 CEACAM1suppressor200ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
14 CHRAC1interactor21.0000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
15 CRKoncoprotein200.47933.753SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16 CRKLoncoprotein220.43355.397SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
17 CSF2RBinteractor50.8330.125fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal
IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Tissue_fac (PF01108, IPR003961): Tissue factor
18 CSF2RBP1interactor100NA
19 CSF3Roncoprotein40.6671.500EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
20 CTNNB1oncoprotein150.34350.482Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
21 CTR9interactor80.7864.000DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
Pap_E4 (PF02711, IPR003861): E4 protein
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
22 CXCR4interactor50.7001.3007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal
23 CYP1A1oncoprotein100p450 (PF00067, IPR001128): Cytochrome P450
24 EFHD2interactor21.0000SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
25 EGFRoncoprotein350.339188.599Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
26 ELAVL1oncoprotein220.190147.703RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
27 EPHA2suppressor90.8930.672fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
28 EPORoncoprotein100.6225.587EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
29 ERBB2oncoprotein230.51935.652Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
30 ERBB3oncoprotein110.8222.062Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
31 ERBB4suppressor90.8930.702Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
32 FASNinteractor40.6670.286Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
33 FCGR2Ainteractor50.5004.333DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
34 FCGR2Boncoprotein21.0000DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
35 FCRL3interactor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
36 FLT1oncoprotein21.0000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
37 FRS2interactor70.8101.387IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
38 FSD1interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
DUF4945 (PF16303, IPR032544): Domain of unknown function (DUF4945)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
39 FYNoncoprotein200.29872.014Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
40 GAB1oncoprotein80.8930.501PH (PF00169, IPR001849, SM00233): PH domain
41 GAB2oncoprotein110.6446.765PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
42 GAB3interactor30.6670.167PH (PF00169, IPR001849, SM00233): PH domain
43 GHRoncoprotein110.5564.866EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
GHBP (PF12772, IPR025871): Growth hormone receptor binding
44 GRB2oncoprotein420.259384.034SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
45 GSK3Bsuppressor60.6002.556Pkinase (PF00069, IPR000719): Protein kinase domain
46 HIST1H2BGoncoprotein100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
47 IGF1Roncoprotein130.7314.594fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
48 IL4Roncoprotein40.5001.125fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal
49 IL6SToncoprotein90.7222.434fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
50 INPP5Dinteractor110.47321.486Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SH2 (PF00017, IPR000980, SM00252): SH2 domain
51 INSRinteractor140.47321.872fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
52 IQCB1interactor30.6670.500DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
53 IRS1interactor170.61015.878CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
54 IRS2oncoprotein120.6676.190CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
55 JAK1oncoprotein210.40554.927FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
56 JAK2oncoprotein260.337104.075FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
57 KIToncoprotein120.6527.690ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
58 LAIR1interactor200Ig_2 (PF13895, IPR007110): Immunoglobulin domain
DUF4448 (PF14610, IPR028000): Protein of unknown function (DUF4448)
59 LEO1interactor80.8212.500Leo1 (PF04004, IPR007149): Leo1-like protein
PPP4R2 (PF09184, IPR015267): PPP4R2
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
60 LGALS3oncoprotein60.5003.667Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
61 LGALS9interactor40.6671.333Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
62 LNX1interactor40.6670.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
63 LRRK1interactor60.7001.019Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
64 LY9interactor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
65 MAP2K1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
66 MAP3K5oncoprotein60.8000.400Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
67 MAPK14oncoprotein70.4675.867Pkinase (PF00069, IPR000719): Protein kinase domain
68 MPZL1interactor60.5335.200Adeno_E3_CR2 (PF02439, IPR003470): Adenovirus E3 region protein CR2
FTR1 (PF03239, IPR004923): Iron permease FTR1 family
Trp_oprn_chp (PF09534, IPR019051): Tryptophan-associated transmembrane protein (Trp_oprn_chp)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
69 MTPNinteractor30.6670.500Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
70 NTRK1oncoprotein340.265273.482I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
71 OVCA2suppressor100FSH1 (PF03959, IPR005645): Serine hydrolase (FSH1)
72 OXCT1interactor60.4004.500CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
73 PAF1oncoprotein70.9520.333Paf1 (PF03985, IPR007133): Paf1
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
74 PDGFRBoncoprotein110.6674.818I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
TonB_N (PF16031): TonB N-terminal region
75 PECAM1oncoprotein60.8000.900C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
76 PIK3R1oncoprotein350.358167.883RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
77 PIK3R2oncoprotein190.52629.896RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
78 PILRAinteractor100SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
G6B (PF15096, IPR028070): G6B family
79 PLCG2interactor80.6792.372C2 (PF00168, IPR000008, SM00239): C2 domain
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
80 PPIFinteractor100Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
81 PRLRoncoprotein50.8330.286EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
82 PTK2protein found in more fusions210.46356.639FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
83 PTK2Binteractor120.6365.784FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
84 RFWD2suppressor31.0000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
85 ROS1oncoprotein21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
86 RPIAinteractor40.6670.667Rib_5-P_isom_A (PF06026, IPR004788): Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
Sugar-bind (PF04198, IPR007324): Putative sugar-binding domain
87 RTF1interactor70.9520.333K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Plus-3 (PF03126, IPR004343): Plus-3 domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
YL1 (PF05764, IPR008895): YL1 nuclear protein
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
88 SELEoncoprotein21.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
89 SIGLEC11interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
90 SIT1interactor21.0000DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
91 SLAMF1interactor40.6670.400ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
SLAM (PF06214, IPR010407): Signaling lymphocytic activation molecule (SLAM) protein
92 SLAMF6oncoprotein100OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
93 SOCS1suppressor180.48431.230SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
94 SOCS3suppressor170.36840.473SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
95 SOS1oncoprotein110.6557.627Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
96 STAMBPinteractor21.0000USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
97 STAT3suppressor210.40063.610SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
98 STAT5Asuppressor130.45512.020SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
99 STAT5Boncoprotein120.47313.343SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
100 SYNCRIPinteractor50.8000.786RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
101 TCEAL1interactor30.6670.500BEX (PF04538, IPR021156): Brain expressed X-linked like family
102 TREML1interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
P12 (PF12669): Virus attachment protein p12 family
DUF3999 (PF13163, IPR025060): Protein of unknown function (DUF3999)
103 TRIM32suppressor200NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
104 TXNIPsuppressor31.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
105 VCAM1interactor70.4296.175C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
106 WDR61interactor61.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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