1 |
PTK2 | parental protein | 114 | 0.084 | 8148.916 | FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein |
2 |
AMPH | oncoprotein | 2 | 1.000 | 0 | BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus |
3 |
APC | suppressor | 3 | 1.000 | 0 | APC_15aa (PF05972, IPR009240): APC 15 residue motif APC_basic (PF05956, IPR009234): APC basic domain APC_r (PF05923): APC repeat Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EB1_binding (PF05937, IPR009232): EB-1 Binding Domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) SAMP (PF05924, IPR009224): SAMP Motif Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4 Arm_APC_u3 (PF16629): Armadillo-associated region on APC APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6 APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain |
4 |
APP | protein found in more fusions | 25 | 0.199 | 163.307 | APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein |
5 |
ARHGAP26 | oncoprotein | 3 | 0.667 | 0.400 | Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein PH (PF00169, IPR001849, SM00233): PH domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain Vps5 (PF09325, IPR015404): Vps5 C terminal like SH3_9 (PF14604, IPR001452): Variant SH3 domain BAR_3 (PF16746): BAR domain of APPL family |
6 |
ASAP1 | interactor | 11 | 0.636 | 5.645 | ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf PH (PF00169, IPR001849, SM00233): PH domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) BAR_3 (PF16746): BAR domain of APPL family |
7 |
ATG12 | interactor | 2 | 1.000 | 0 | APG12 (PF04110, IPR007242): Ubiquitin-like autophagy protein Apg12 |
8 |
BBS10 | interactor | 1 | 0 | 0 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
9 |
BCAR1 | oncoprotein | 18 | 0.497 | 29.022 | Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) Caskin1-CID (PF16600): Caskin1 CASK-interaction domain |
10 |
BIN1 | suppressor | 6 | 0.400 | 5.333 | BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
11 |
BMX | interactor | 8 | 0.750 | 1.794 | BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain PH_8 (PF15409): Pleckstrin homology domain |
12 |
CBL | suppressor | 37 | 0.343 | 173.612 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain |
13 |
CCNA1 | interactor | 4 | 0.500 | 1.750 | Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N |
14 |
CCR5 | interactor | 4 | 0.833 | 0.500 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) |
15 |
CIB1 | interactor | 1 | 0 | 0 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
16 |
CRK | oncoprotein | 21 | 0.448 | 47.068 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
17 |
CSK | interactor | 12 | 0.561 | 11.772 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
18 |
CTTN | oncoprotein | 14 | 0.462 | 19.815 | FadA (PF09403, IPR018543): Adhesion protein FadA HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
19 |
CXCR4 | interactor | 6 | 0.667 | 2.619 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal |
20 |
DAG1 | interactor | 11 | 0.455 | 12.512 | DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1) |
21 |
DCC | suppressor | 3 | 0.667 | 0.500 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neogenin_C (PF06583, IPR010560): Neogenin C-terminus DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
22 |
DDX39A | interactor | 4 | 1.000 | 0 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
23 |
DEF6 | interactor | 3 | 0.667 | 1.000 | ArgK (PF03308, IPR005129): ArgK protein HSP70 (PF00012, IPR013126): Hsp70 protein PH (PF00169, IPR001849, SM00233): PH domain zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein EF-hand_6 (PF13405, IPR002048): EF-hand domain |
24 |
DOCK1 | interactor | 8 | 0.536 | 5.702 | DHR-2 (PF06920, IPR010703): Dock homology region 2 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein TetR_C_8 (PF14278): Transcriptional regulator C-terminal region DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins SH3_9 (PF14604, IPR001452): Variant SH3 domain DOCK_N (PF16172, IPR032376): DOCK N-terminus |
25 |
DOK4 | interactor | 5 | 0.600 | 1.018 | IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain |
26 |
EEF1G | protein found in more fusions | 8 | 0.619 | 2.861 | EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein |
27 |
EGFR | oncoprotein | 46 | 0.270 | 354.666 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
28 |
ELAVL1 | oncoprotein | 32 | 0.170 | 273.535 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
29 |
EPHA2 | suppressor | 14 | 0.538 | 21.561 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
30 |
EPS8L2 | interactor | 2 | 1.000 | 0 | PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
31 |
ERBB2 | oncoprotein | 31 | 0.338 | 147.025 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
32 |
EZR | protein found in more fusions | 11 | 0.378 | 16.919 | DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
33 |
F13A1 | protein found in more fusions | 2 | 0 | 0 | Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily |
34 |
FBP1 | suppressor | 3 | 1.000 | 0 | FBPase (PF00316, IPR000146): Fructose-1-6-bisphosphatase, N-terminal domain |
35 |
FGR | oncoprotein | 8 | 0.786 | 1.206 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
36 |
FYN | oncoprotein | 21 | 0.347 | 62.521 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
37 |
GAPDH | oncoprotein | 13 | 0.515 | 12.652 | Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein |
38 |
GIT1 | interactor | 9 | 0.464 | 6.487 | ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) FlxA (PF14282, IPR025577): FlxA-like protein GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor |
39 |
GNB1 | interactor | 5 | 0.600 | 2.472 | Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
40 |
GNG2 | interactor | 3 | 1.000 | 0 | G-gamma (PF00631, IPR015898, SM00224): GGL domain SidE (PF12252, IPR021014): Dot/Icm substrate protein |
41 |
GRB2 | oncoprotein | 38 | 0.323 | 199.908 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
42 |
GRB7 | interactor | 3 | 0.667 | 0.167 | BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain |
43 |
GSK3B | suppressor | 15 | 0.330 | 42.325 | Pkinase (PF00069, IPR000719): Protein kinase domain |
44 |
GSN | suppressor | 8 | 0.571 | 4.710 | Gelsolin (PF00626, IPR007123): Gelsolin repeat |
45 |
HCK | oncoprotein | 11 | 0.618 | 6.940 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
46 |
HES1 | oncoprotein | 7 | 0.571 | 3.919 | Hairy_orange (PF07527, IPR003650): Hairy Orange HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain |
47 |
HSP90AA1 | oncoprotein | 28 | 0.356 | 97.103 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
48 |
IGF1R | oncoprotein | 19 | 0.456 | 40.059 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain |
49 |
IQGAP1 | interactor | 15 | 0.429 | 28.855 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain |
50 |
IRS1 | interactor | 13 | 0.667 | 8.003 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain |
51 |
ITGA4 | interactor | 13 | 0.409 | 20.993 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha |
52 |
ITGB3 | suppressor | 5 | 0.600 | 1.519 | EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain |
53 |
ITGB5 | interactor | 2 | 1.000 | 0 | EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain |
54 |
JAK2 | oncoprotein | 22 | 0.414 | 68.505 | FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
55 |
LPXN | interactor | 1 | 0 | 0 | LIM (PF00412, IPR001781, SM00132): LIM domain zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger |
56 |
LYN | oncoprotein | 19 | 0.444 | 29.308 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
57 |
MAPK8IP3 | interactor | 3 | 1.000 | 0 | Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II |
58 |
MDM2 | oncoprotein | 14 | 0.474 | 19.767 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
59 |
NACAD | interactor | 3 | 1.000 | 0 | NAC (PF01849, IPR002715): NAC domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain |
60 |
NASP | interactor | 2 | 1.000 | 0 | Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) SlyX (PF04102, IPR007236): SlyX TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV) SHNi-TPR (PF10516, IPR019544): SHNi-TPR XhlA (PF10779, IPR019715): Haemolysin XhlA TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 |
61 |
NCK1 | oncoprotein | 14 | 0.440 | 26.001 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
62 |
NCK2 | interactor | 14 | 0.308 | 27.340 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
63 |
NEDD9 | protein found in more fusions | 11 | 0.444 | 10.025 | Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) SH3_9 (PF14604, IPR001452): Variant SH3 domain |
64 |
NEO1 | interactor | 2 | 1.000 | 0 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neogenin_C (PF06583, IPR010560): Neogenin C-terminus V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
65 |
NTRK1 | oncoprotein | 41 | 0.201 | 427.554 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
66 |
OTUD6B | interactor | 2 | 1.000 | 0 | Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57 Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family HemY_N (PF07219, IPR010817): HemY protein N-terminus OTU (PF02338, IPR003323): OTU-like cysteine protease DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335) |
67 |
PARP1 | suppressor | 8 | 0.476 | 6.356 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region |
68 |
PDCD6IP | interactor | 11 | 0.600 | 6.384 | BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV |
69 |
PIAS1 | suppressor | 8 | 0.571 | 7.167 | Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544 |
70 |
PIK3R1 | oncoprotein | 25 | 0.507 | 43.315 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
71 |
PIK3R3 | interactor | 15 | 0.581 | 11.022 | SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
72 |
PKD1 | suppressor | 2 | 0 | 0 | Stress-antifung (PF01657, IPR002902): Salt stress response/antifungal LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain PKD (PF00801, IPR000601, SM00089): PKD domain PKD_channel (PF08016, IPR013122): Polycystin cation channel PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain REJ (PF02010, IPR002859): REJ domain WSC (PF01822, IPR002889, SM00321): WSC domain Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain LRR_8 (PF13855, IPR001611): Leucine rich repeat fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II |
73 |
PLCG1 | oncoprotein | 14 | 0.560 | 19.236 | C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain |
74 |
PPP1CA | suppressor | 13 | 0.372 | 28.399 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
75 |
PPP1CB | interactor | 8 | 0.571 | 5.443 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
76 |
PTAFR | interactor | 2 | 1.000 | 0 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) |
77 |
PTEN | suppressor | 10 | 0.400 | 14.229 | DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein |
78 |
PTPN11 | suppressor | 21 | 0.463 | 48.016 | SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase |
79 |
PTPN6 | suppressor | 10 | 0.600 | 8.468 | SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus |
80 |
PTRH2 | interactor | 1 | 0 | 0 | PTH2 (PF01981, IPR002833): Peptidyl-tRNA hydrolase PTH2 |
81 |
PXN | oncoprotein | 26 | 0.298 | 134.401 | LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family |
82 |
RAC1 | oncoprotein | 8 | 0.333 | 9.267 | Ras (PF00071, IPR001806, SM00173): Ras family |
83 |
RB1CC1 | suppressor | 2 | 1.000 | 0 | Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II DHC (PF09626, IPR018588): Dihaem cytochrome c DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) ATG11 (PF10377, IPR019460): Autophagy-related protein 11 DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Jag_N (PF14804, IPR032782): Jag N-terminus NPBW (PF15180, IPR013297): Neuropeptides B and W HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain |
84 |
RBSN | interactor | 1 | 0 | 0 | DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Histone_HNS (PF00816, IPR001801): H-NS histone family zf-AD (PF07776, IPR012934, SM00868): Zinc-finger associated domain (zf-AD) Rbsn (PF11464, IPR021565): Rabenosyn Rab binding domain DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637) NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif |
85 |
RET | oncoprotein | 14 | 0.615 | 13.831 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Cadherin (PF00028, IPR002126, SM00112): Cadherin domain |
86 |
SAE1 | interactor | 3 | 0.667 | 0.222 | ThiF (PF00899, IPR000594): ThiF family |
87 |
SELE | oncoprotein | 4 | 0.500 | 0.722 | EGF (PF00008, IPR000742, SM00181): EGF-like domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain |
88 |
SH2D1A | interactor | 6 | 0.533 | 1.599 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
89 |
SH2D1B | interactor | 3 | 0.667 | 0.182 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
90 |
SH2D2A | interactor | 11 | 0.636 | 11.826 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
91 |
SH3KBP1 | protein found in more fusions | 17 | 0.533 | 19.101 | Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein SH3_9 (PF14604, IPR001452): Variant SH3 domain |
92 |
SHC1 | oncoprotein | 21 | 0.479 | 33.986 | PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
93 |
SOCS2 | oncoprotein | 3 | 1.000 | 0 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box |
94 |
SOCS3 | suppressor | 12 | 0.455 | 20.399 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box |
95 |
SRC | oncoprotein | 39 | 0.299 | 257.949 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
96 |
SRPK1 | interactor | 9 | 0.417 | 10.396 | FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 |
97 |
STAP2 | interactor | 3 | 1.000 | 0 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
98 |
STAT1 | suppressor | 10 | 0.639 | 7.392 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain |
99 |
STAT3 | suppressor | 27 | 0.385 | 104.879 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain |
100 |
STUB1 | suppressor | 9 | 0.714 | 2.687 | U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat |
101 |
SYK | suppressor | 22 | 0.419 | 53.148 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
102 |
TGFB1I1 | interactor | 4 | 0.667 | 1.333 | LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family |
103 |
TLN1 | interactor | 9 | 0.361 | 10.270 | DUF1013 (PF06242, IPR010421): Protein of unknown function (DUF1013) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Talin_middle (PF09141, IPR015224): Talin, middle domain VBS (PF08913, IPR015009): Vinculin Binding Site CoatB (PF10389, IPR008020): Bacteriophage coat protein B LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM |
104 |
TP53 | suppressor | 21 | 0.321 | 72.003 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
105 |
TRIM15 | suppressor | 9 | 0.536 | 3.614 | Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta |
106 |
TRIM72 | interactor | 2 | 1.000 | 0 | HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
107 |
TRIP6 | interactor | 8 | 0.464 | 6.496 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region LIM (PF00412, IPR001781, SM00132): LIM domain |
108 |
TRMT6 | interactor | 2 | 1.000 | 0 | Gcd10p (PF04189, IPR007316): Gcd10p family Presenilin (PF01080, IPR001108): Presenilin INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus |
109 |
TSC1 | suppressor | 6 | 0.500 | 3.667 | Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein |
110 |
TSC2 | suppressor | 5 | 0.600 | 2.167 | Rap_GAP (PF02145, IPR000331): Rap/ran-GAP Tuberin (PF03542, IPR018515): Tuberin DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384) Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 |
111 |
UBE2H | protein found in more fusions | 4 | 0.667 | 1.000 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family |
112 |
VPS16 | interactor | 3 | 0.667 | 0.500 | Vps16_C (PF04840, IPR006925): Vps16, C-terminal region Vps16_N (PF04841, IPR006926): Vps16, N-terminal region |
113 |
YES1 | oncoprotein | 10 | 0.467 | 9.744 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain YdjC (PF04794, IPR006879): YdjC-like protein SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
114 |
ZNF331 | oncoprotein | 1 | 0 | 0 | KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |