Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PTK2 (from a repository: Mon Jan 25 10:12:22 2021)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PNG file PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 114 The number (and %) of the onco-proteins 39 (34.21 %) The number (and %) of the tumor suppressors 26 (22.81 %) Total number of binary PPIs (saturation %) 694 (10.77 %) The number (and %) of affected PPIs 114 (16.43 %) The number of possible different fusions 32 PPI diameter 2 PPI radius 1 The average degree of PPI 11.351 Assortativity coefficient -0.2607 The network average Clustering coefficient 0.546 The number (and %) of a zero Clustering coefficients 8 (7.02 %) The number (and %) of a zero Betweenness Centrality 27 (23.68 %)

ACTIVE INTERACTORS MISSING INTERACTORS (in fusions)

List of the fusions
PPI for parental proteins: PTK2	All fusions : BE929722;
Proteins found in more fusions	PTPN11 (see 1 fusions); APP (see 4 fusions); SYK (see 1 fusions); EEF1G (see 1 fusions); HSP90AA1 (see 2 fusions); LYN (see 2 fusions); PKD1 (see 1 fusions); CBL (see 1 fusions); GSK3B (see 1 fusions); JAK2 (see 3 fusions); GRB2 (see 1 fusions); RAC1 (see 1 fusions); FYN (see 1 fusions); STAT3 (see 2 fusions); UBE2H (see 4 fusions); PIAS1 (see 2 fusions); EZR (see 2 fusions); SH3KBP1 (see 1 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); APC (see 1 fusions); STUB1 (see 1 fusions); NEDD9 (see 1 fusions); CTTN (see 1 fusions); SHC1 (see 1 fusions); PTK2 (see 2 fusions); PARP1 (see 1 fusions); STAT1 (see 1 fusions); TP53 (see 3 fusions); GAPDH (see 2 fusions); F13A1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PTK2	parental protein	114	0.084	8148.916	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
2	AMPH	oncoprotein	2	1.000	0	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
3	APC	suppressor	3	1.000	0	APC_15aa (PF05972, IPR009240): APC 15 residue motif APC_basic (PF05956, IPR009234): APC basic domain APC_r (PF05923): APC repeat Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EB1_binding (PF05937, IPR009232): EB-1 Binding Domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) SAMP (PF05924, IPR009224): SAMP Motif Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4 Arm_APC_u3 (PF16629): Armadillo-associated region on APC APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6 APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
4	APP	protein found in more fusions	25	0.199	163.307	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5	ARHGAP26	oncoprotein	3	0.667	0.400	Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein PH (PF00169, IPR001849, SM00233): PH domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain Vps5 (PF09325, IPR015404): Vps5 C terminal like SH3_9 (PF14604, IPR001452): Variant SH3 domain BAR_3 (PF16746): BAR domain of APPL family
6	ASAP1	interactor	11	0.636	5.645	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf PH (PF00169, IPR001849, SM00233): PH domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) BAR_3 (PF16746): BAR domain of APPL family
7	ATG12	interactor	2	1.000	0	APG12 (PF04110, IPR007242): Ubiquitin-like autophagy protein Apg12
8	BBS10	interactor	1	0	0	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
9	BCAR1	oncoprotein	18	0.497	29.022	Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
10	BIN1	suppressor	6	0.400	5.333	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
11	BMX	interactor	8	0.750	1.794	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain PH_8 (PF15409): Pleckstrin homology domain
12	CBL	suppressor	37	0.343	173.612	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
13	CCNA1	interactor	4	0.500	1.750	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
14	CCR5	interactor	4	0.833	0.500	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
15	CIB1	interactor	1	0	0	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
16	CRK	oncoprotein	21	0.448	47.068	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
17	CSK	interactor	12	0.561	11.772	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
18	CTTN	oncoprotein	14	0.462	19.815	FadA (PF09403, IPR018543): Adhesion protein FadA HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
19	CXCR4	interactor	6	0.667	2.619	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal
20	DAG1	interactor	11	0.455	12.512	DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
21	DCC	suppressor	3	0.667	0.500	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neogenin_C (PF06583, IPR010560): Neogenin C-terminus DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
22	DDX39A	interactor	4	1.000	0	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23	DEF6	interactor	3	0.667	1.000	ArgK (PF03308, IPR005129): ArgK protein HSP70 (PF00012, IPR013126): Hsp70 protein PH (PF00169, IPR001849, SM00233): PH domain zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein EF-hand_6 (PF13405, IPR002048): EF-hand domain
24	DOCK1	interactor	8	0.536	5.702	DHR-2 (PF06920, IPR010703): Dock homology region 2 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein TetR_C_8 (PF14278): Transcriptional regulator C-terminal region DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins SH3_9 (PF14604, IPR001452): Variant SH3 domain DOCK_N (PF16172, IPR032376): DOCK N-terminus
25	DOK4	interactor	5	0.600	1.018	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
26	EEF1G	protein found in more fusions	8	0.619	2.861	EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
27	EGFR	oncoprotein	46	0.270	354.666	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
28	ELAVL1	oncoprotein	32	0.170	273.535	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
29	EPHA2	suppressor	14	0.538	21.561	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
30	EPS8L2	interactor	2	1.000	0	PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31	ERBB2	oncoprotein	31	0.338	147.025	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
32	EZR	protein found in more fusions	11	0.378	16.919	DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
33	F13A1	protein found in more fusions	2	0	0	Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
34	FBP1	suppressor	3	1.000	0	FBPase (PF00316, IPR000146): Fructose-1-6-bisphosphatase, N-terminal domain
35	FGR	oncoprotein	8	0.786	1.206	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
36	FYN	oncoprotein	21	0.347	62.521	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
37	GAPDH	oncoprotein	13	0.515	12.652	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
38	GIT1	interactor	9	0.464	6.487	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) FlxA (PF14282, IPR025577): FlxA-like protein GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
39	GNB1	interactor	5	0.600	2.472	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
40	GNG2	interactor	3	1.000	0	G-gamma (PF00631, IPR015898, SM00224): GGL domain SidE (PF12252, IPR021014): Dot/Icm substrate protein
41	GRB2	oncoprotein	38	0.323	199.908	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
42	GRB7	interactor	3	0.667	0.167	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
43	GSK3B	suppressor	15	0.330	42.325	Pkinase (PF00069, IPR000719): Protein kinase domain
44	GSN	suppressor	8	0.571	4.710	Gelsolin (PF00626, IPR007123): Gelsolin repeat
45	HCK	oncoprotein	11	0.618	6.940	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
46	HES1	oncoprotein	7	0.571	3.919	Hairy_orange (PF07527, IPR003650): Hairy Orange HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
47	HSP90AA1	oncoprotein	28	0.356	97.103	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
48	IGF1R	oncoprotein	19	0.456	40.059	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain
49	IQGAP1	interactor	15	0.429	28.855	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain
50	IRS1	interactor	13	0.667	8.003	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
51	ITGA4	interactor	13	0.409	20.993	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
52	ITGB3	suppressor	5	0.600	1.519	EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain
53	ITGB5	interactor	2	1.000	0	EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain
54	JAK2	oncoprotein	22	0.414	68.505	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
55	LPXN	interactor	1	0	0	LIM (PF00412, IPR001781, SM00132): LIM domain zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
56	LYN	oncoprotein	19	0.444	29.308	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
57	MAPK8IP3	interactor	3	1.000	0	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
58	MDM2	oncoprotein	14	0.474	19.767	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
59	NACAD	interactor	3	1.000	0	NAC (PF01849, IPR002715): NAC domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain
60	NASP	interactor	2	1.000	0	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) SlyX (PF04102, IPR007236): SlyX TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV) SHNi-TPR (PF10516, IPR019544): SHNi-TPR XhlA (PF10779, IPR019715): Haemolysin XhlA TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
61	NCK1	oncoprotein	14	0.440	26.001	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
62	NCK2	interactor	14	0.308	27.340	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
63	NEDD9	protein found in more fusions	11	0.444	10.025	Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) SH3_9 (PF14604, IPR001452): Variant SH3 domain
64	NEO1	interactor	2	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neogenin_C (PF06583, IPR010560): Neogenin C-terminus V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
65	NTRK1	oncoprotein	41	0.201	427.554	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
66	OTUD6B	interactor	2	1.000	0	Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57 Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family HemY_N (PF07219, IPR010817): HemY protein N-terminus OTU (PF02338, IPR003323): OTU-like cysteine protease DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
67	PARP1	suppressor	8	0.476	6.356	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
68	PDCD6IP	interactor	11	0.600	6.384	BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
69	PIAS1	suppressor	8	0.571	7.167	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
70	PIK3R1	oncoprotein	25	0.507	43.315	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
71	PIK3R3	interactor	15	0.581	11.022	SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
72	PKD1	suppressor	2	0	0	Stress-antifung (PF01657, IPR002902): Salt stress response/antifungal LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain PKD (PF00801, IPR000601, SM00089): PKD domain PKD_channel (PF08016, IPR013122): Polycystin cation channel PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain REJ (PF02010, IPR002859): REJ domain WSC (PF01822, IPR002889, SM00321): WSC domain Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain LRR_8 (PF13855, IPR001611): Leucine rich repeat fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
73	PLCG1	oncoprotein	14	0.560	19.236	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
74	PPP1CA	suppressor	13	0.372	28.399	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
75	PPP1CB	interactor	8	0.571	5.443	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
76	PTAFR	interactor	2	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
77	PTEN	suppressor	10	0.400	14.229	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
78	PTPN11	suppressor	21	0.463	48.016	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
79	PTPN6	suppressor	10	0.600	8.468	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
80	PTRH2	interactor	1	0	0	PTH2 (PF01981, IPR002833): Peptidyl-tRNA hydrolase PTH2
81	PXN	oncoprotein	26	0.298	134.401	LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family
82	RAC1	oncoprotein	8	0.333	9.267	Ras (PF00071, IPR001806, SM00173): Ras family
83	RB1CC1	suppressor	2	1.000	0	Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II DHC (PF09626, IPR018588): Dihaem cytochrome c DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) ATG11 (PF10377, IPR019460): Autophagy-related protein 11 DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Jag_N (PF14804, IPR032782): Jag N-terminus NPBW (PF15180, IPR013297): Neuropeptides B and W HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
84	RBSN	interactor	1	0	0	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Histone_HNS (PF00816, IPR001801): H-NS histone family zf-AD (PF07776, IPR012934, SM00868): Zinc-finger associated domain (zf-AD) Rbsn (PF11464, IPR021565): Rabenosyn Rab binding domain DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637) NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
85	RET	oncoprotein	14	0.615	13.831	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
86	SAE1	interactor	3	0.667	0.222	ThiF (PF00899, IPR000594): ThiF family
87	SELE	oncoprotein	4	0.500	0.722	EGF (PF00008, IPR000742, SM00181): EGF-like domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
88	SH2D1A	interactor	6	0.533	1.599	SH2 (PF00017, IPR000980, SM00252): SH2 domain
89	SH2D1B	interactor	3	0.667	0.182	SH2 (PF00017, IPR000980, SM00252): SH2 domain
90	SH2D2A	interactor	11	0.636	11.826	SH2 (PF00017, IPR000980, SM00252): SH2 domain
91	SH3KBP1	protein found in more fusions	17	0.533	19.101	Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
92	SHC1	oncoprotein	21	0.479	33.986	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
93	SOCS2	oncoprotein	3	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
94	SOCS3	suppressor	12	0.455	20.399	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
95	SRC	oncoprotein	39	0.299	257.949	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
96	SRPK1	interactor	9	0.417	10.396	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
97	STAP2	interactor	3	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain
98	STAT1	suppressor	10	0.639	7.392	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
99	STAT3	suppressor	27	0.385	104.879	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
100	STUB1	suppressor	9	0.714	2.687	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
101	SYK	suppressor	22	0.419	53.148	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
102	TGFB1I1	interactor	4	0.667	1.333	LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family
103	TLN1	interactor	9	0.361	10.270	DUF1013 (PF06242, IPR010421): Protein of unknown function (DUF1013) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Talin_middle (PF09141, IPR015224): Talin, middle domain VBS (PF08913, IPR015009): Vinculin Binding Site CoatB (PF10389, IPR008020): Bacteriophage coat protein B LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM
104	TP53	suppressor	21	0.321	72.003	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
105	TRIM15	suppressor	9	0.536	3.614	Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
106	TRIM72	interactor	2	1.000	0	HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
107	TRIP6	interactor	8	0.464	6.496	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region LIM (PF00412, IPR001781, SM00132): LIM domain
108	TRMT6	interactor	2	1.000	0	Gcd10p (PF04189, IPR007316): Gcd10p family Presenilin (PF01080, IPR001108): Presenilin INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus
109	TSC1	suppressor	6	0.500	3.667	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein
110	TSC2	suppressor	5	0.600	2.167	Rap_GAP (PF02145, IPR000331): Rap/ran-GAP Tuberin (PF03542, IPR018515): Tuberin DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384) Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
111	UBE2H	protein found in more fusions	4	0.667	1.000	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
112	VPS16	interactor	3	0.667	0.500	Vps16_C (PF04840, IPR006925): Vps16, C-terminal region Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
113	YES1	oncoprotein	10	0.467	9.744	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain YdjC (PF04794, IPR006879): YdjC-like protein SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
114	ZNF331	oncoprotein	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

B a c k    t o    T o p ⇑

List of missing interactors (in fusions)

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ATG12	interactor	APG12 (PF04110, IPR007242): Ubiquitin-like autophagy protein Apg12	BE929722
2	CCNA1	interactor	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N	BE929722
3	DAG1	interactor	DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)	BE929722
4	DCC	suppressor	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neogenin_C (PF06583, IPR010560): Neogenin C-terminus DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain	BE929722
5	FBP1	suppressor	FBPase (PF00316, IPR000146): Fructose-1-6-bisphosphatase, N-terminal domain	BE929722
6	GNG2	interactor	G-gamma (PF00631, IPR015898, SM00224): GGL domain SidE (PF12252, IPR021014): Dot/Icm substrate protein	BE929722
7	HES1	oncoprotein	Hairy_orange (PF07527, IPR003650): Hairy Orange HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain	BE929722
8	NEO1	interactor	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neogenin_C (PF06583, IPR010560): Neogenin C-terminus V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain	BE929722
9	PTK2	parental protein	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein	BE929722
10	PTRH2	interactor	PTH2 (PF01981, IPR002833): Peptidyl-tRNA hydrolase PTH2	BE929722
11	UBE2H	interactor	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family	BE929722
12	ZNF331	oncoprotein	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain	BE929722

B a c k    t o    T o p ⇑