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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)150
The number (and %) of the onco-proteins28 (18.67 %)
The number (and %) of the tumor suppressors22 (14.67 %)
Total number of binary PPIs (saturation %)874 (7.82 %)
The number (and %) of affected PPIs150 (17.16 %)
The number of possible different fusions20
PPI diameter2
PPI radius1
The average degree of PPI11.027
Assortativity coefficient-0.3047
The network average Clustering coefficient0.585
The number (and %) of a zero Clustering coefficients17 (11.33 %)
The number (and %) of a zero Betweenness Centrality47 (31.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PSME3 All fusions
: BU678578; BM971211;
Proteins found in more fusions PSMC2 (see 1 fusions); SRSF2 (see 1 fusions); TRIM33 (see 1 fusions); NPM1 (see 1 fusions); HUWE1 (see 2 fusions); PSMB3 (see 1 fusions); AHNAK (see 2 fusions); LUC7L (see 1 fusions); PSME3 (see 2 fusions); CREBBP (see 5 fusions); AHCYL1 (see 3 fusions); BAG3 (see 4 fusions); PIAS1 (see 2 fusions); PSMA7 (see 2 fusions); ATN1 (see 1 fusions); UBC (see 1 fusions); PML (see 4 fusions); PSMC5 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PSME3parental protein1500.06117552.886PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
2 ADAP1interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
3 ADARB2oncoprotein100dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
A_deamin (PF02137, IPR002466, SM00552): Adenosine-deaminase (editase) domain
4 AHCYL1suppressor90.3576.613AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
5 AHNAKsuppressor60.7001.500DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945)
ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein
DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993)
DUF4097 (PF13349, IPR025164): Putative adhesin
Ntox37 (PF15535, IPR029108): Bacterial toxin 37
6 AICDAinteractor31.0000APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
7 ARHGEF2oncoprotein40.5000.876IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
8 ATN1protein found in more fusions31.0000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
9 ATP5Binteractor80.5713.469AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
10 BAG3oncoprotein190.70626.749BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
11 BAP1suppressor30.6671.000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
12 BBS2interactor100BBS2_N (PF14781, IPR029430): Ciliary BBSome complex subunit 2, N-terminal
BBS2_C (PF14782, IPR029333): Ciliary BBSome complex subunit 2, C-terminal
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
13 C1QBPinteractor100.35620.510MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
14 CAMTA2interactor21.0000CG-1 (PF03859, IPR005559, SM01076): CG-1 domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
TIG (PF01833, IPR002909): IPT/TIG domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
dbPDZ_assoc (PF16610): Unstructured region between two PDZ domains on Dlg5
15 CBX2interactor40.8330.667AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
CBX7_C (PF17218): CBX family C-terminal motif
16 CBX4oncoprotein60.7002.333Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
CBX7_C (PF17218): CBX family C-terminal motif
17 CCAR2suppressor80.35712.994DREPP (PF05558, IPR008469): DREPP plasma membrane polypeptide
IncA (PF04156, IPR007285): IncA protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DBC1 (PF14443, IPR025954, SM01122): DBC1
S1-like (PF14444, IPR025223): S1-like
18 CDKN1Asuppressor110.6007.369CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
19 CDKN2Asuppressor110.52711.636Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
20 CHD8oncoprotein30.6670.286BUD22 (PF09073, IPR015158): BUD22
CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
21 CHEK2suppressor70.8001.286FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
22 CLK2interactor90.42910.500DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-met (PF12874): Zinc-finger of C2H2 type
23 CLK3interactor80.5247.233Pkinase (PF00069, IPR000719): Protein kinase domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
24 CMSS1interactor21.0000CMS1 (PF14617, IPR032704): U3-containing 90S pre-ribosomal complex subunit
25 COILinteractor80.28614.067CDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
26 CREBBPsuppressor110.55611.571Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
27 DEPTORinteractor21.0000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PDZ_2 (PF13180, IPR001478): PDZ domain
Complex1_LYR_2 (PF13233): Complex1_LYR-like
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
28 DIEXFinteractor100UTP25 (PF06862, IPR010678): Utp25, U3 small nucleolar RNA-associated SSU processome protein 25
eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
SDA1 (PF05285, IPR007949): SDA1
29 DIP2Ainteractor30.6670.667AMP-binding (PF00501, IPR000873): AMP-binding enzyme
Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
30 DTNBP1interactor21.0000Dysbindin (PF04440, IPR007531): Dysbindin (Dystrobrevin binding protein 1)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
31 EAF1suppressor50.4006.000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Peroxin-3 (PF04882, IPR006966): Peroxin-3
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
32 EAF2suppressor21.0000Paf1 (PF03985, IPR007133): Paf1
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
33 ELF2interactor21.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
Elf-1_N (PF12310, IPR022084): Transcription factor protein N terminal
34 FAM192Ainteractor100.28928.293VIT1 (PF01988, IPR008217): VIT family
Nefa_Nip30_N (PF10187, IPR019331): N-terminal domain of NEFA-interacting nuclear protein NIP30
35 FBXL19interactor100AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
RbpA (PF13397, IPR025182): RNA polymerase-binding protein
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PHD_4 (PF16866, IPR019787): PHD-finger
36 FBXO7interactor100.55610.383Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
F-box-like (PF12937, IPR001810): F-box-like
37 FLYWCH2interactor100FLYWCH_N (PF15423, IPR029279): FLYWCH-type zinc finger-containing protein
38 FXR2interactor40.6671.000Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
39 GATAD2Ainteractor100DUF2299 (PF10061, IPR018747): Uncharacterized conserved protein (DUF2299)
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
P66_CC (PF16563, IPR032346): Coiled-coil and interaction region of P66A and P66B with MBD2
40 GTF2F1interactor60.3337.900TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
41 GTPBP4suppressor40.8330.286DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
MRC1 (PF09444, IPR018564): MRC1-like domain
NOG1 (PF06858, IPR010674): Nucleolar GTP-binding protein 1 (NOG1)
NOGCT (PF08155, IPR012973): NOGCT (NUC087) domain
Lip_prot_lig_C (PF10437, IPR019491): Bacterial lipoate protein ligase C-terminus
AAA_16 (PF13191): AAA ATPase domain
42 HDGFinteractor60.4674.593PWWP (PF00855, IPR000313, SM00293): PWWP domain
43 HIBCHinteractor100ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
44 HSPA5oncoprotein230.32993.314HSP70 (PF00012, IPR013126): Hsp70 protein
45 HUWE1oncoprotein330.442154.132BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
46 ITGA4interactor150.57117.380FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
47 ITPKBinteractor100IPK (PF03770, IPR005522): Inositol polyphosphate kinase
48 KANSL1interactor21.0000PEHE (PF15275, IPR029332): PEHE domain
49 KAT14oncoprotein31.0000Acetyltransf_10 (PF13673, IPR000182): Acetyltransferase (GNAT) domain
50 KLF2interactor30.6670.400CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
51 L3MBTL2interactor30.6671.000MBT (PF02820, IPR004092, SM00561): mbt repeat
52 LCA5interactor30.6671.000IncA (PF04156, IPR007285): IncA protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
53 LIG3interactor30.6670.143DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
HD_2 (PF12917, IPR027366): HD containing hydrolase-like enzyme
Synaptonemal_3 (PF15191, IPR028145): Synaptonemal complex central element protein 3
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
54 LUC7Lprotein found in more fusions100.38917.733LUC7 (PF03194, IPR004882): LUC7 N_terminus
Hid1 (PF12722): High-temperature-induced dauer-formation protein
55 MBIPinteractor80.47610.000DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
56 MBTD1interactor100C1_2 (PF03107, IPR004146): C1 domain
MBT (PF02820, IPR004092, SM00561): mbt repeat
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
57 MCCsuppressor30.6670.400ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
FAM76 (PF16046, IPR032017): FAM76 protein
58 MDM2oncoprotein250.333113.673Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
59 MED4interactor100.31121.524Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
60 MGAinteractor40.6672.000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
T-box (PF00907, IPR001699, SM00425): T-box
DUF4801 (PF16059, IPR032060): Domain of unknown function (DUF4801)
Tristanin_u2 (PF16638): Unstructured region on methyltransferase between zinc-fingers
61 MOV10interactor170.23567.047AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
62 MYH9suppressor110.38219.086IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
63 NCOA3oncoprotein90.5288.025DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
64 NPM1suppressor290.259194.842Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
65 NUDT18interactor21.0000NUDIX (PF00293, IPR000086): NUDIX domain
66 NUP50interactor21.0000NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa)
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
67 NXF1interactor270.145215.283NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
68 PARD3interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
69 PARK2suppressor300.62874.804IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
70 PCGF6interactor70.33310.000DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
71 PFDN5interactor21.0000Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
72 PIAS1suppressor90.5368.891Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
73 PMLsuppressor120.5829.684zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
74 PRKAB2interactor40.6670.667AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
75 PRR13interactor40.6671.000DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
76 PRR14Linteractor100Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
77 PSMA1interactor320.66984.790Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
78 PSMA2interactor320.72055.675Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
79 PSMA3interactor440.419323.318Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
80 PSMA4interactor270.79832.085Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
81 PSMA5oncoprotein290.79317.750Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
82 PSMA6interactor310.75322.881Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
83 PSMA7protein found in more fusions330.71051.004Proteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
84 PSMA8interactor200.9322.922Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
Myb_DNA-bind_5 (PF13873, IPR028002): Myb/SANT-like DNA-binding domain
85 PSMB1interactor310.71039.501Proteasome (PF00227, IPR001353): Proteasome subunit
86 PSMB2interactor270.8409.790Proteasome (PF00227, IPR001353): Proteasome subunit
87 PSMB3protein found in more fusions270.84910.493Proteasome (PF00227, IPR001353): Proteasome subunit
88 PSMB4interactor260.8688.384Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Proteasome (PF00227, IPR001353): Proteasome subunit
89 PSMB9interactor260.79029.770Proteasome (PF00227, IPR001353): Proteasome subunit
90 PSMC2protein found in more fusions300.78336.761AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
91 PSMC5protein found in more fusions380.571118.968AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
92 PSMD1interactor310.71635.383PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
93 PSMD11interactor290.76139.984DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
94 PSMD12interactor290.80222.370Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
95 PSMD14interactor260.9173.021JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
96 PSMD2oncoprotein340.59291.360PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
97 PSMD4interactor300.70842.945UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
98 PSMD8interactor280.82830.735CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
99 RAB40Aoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
SOCS_box (PF07525, IPR001496): SOCS box
100 RAB40ALoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
SOCS_box (PF07525, IPR001496): SOCS box
101 RAD18interactor50.5002.333PhoU_div (PF01865, IPR018445): Protein of unknown function DUF47
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
102 RALYinteractor90.27817.280RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
103 RNPS1interactor110.41821.467RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
104 RSRP1oncoprotein50.6002.733RSRP (PF17069): Arginine/Serine-Rich protein 1
105 RTEL1oncoprotein21.0000C1_2 (PF03107, IPR004146): C1 domain
DEAD_2 (PF06733, IPR010614): DEAD_2
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
DZR (PF12773, IPR025874): Double zinc ribbon
Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain
CCM2_C (PF16545, IPR032375): Cerebral cavernous malformation protein, harmonin-homology
106 SALL2suppressor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
MPP6 (PF10175, IPR019324): M-phase phosphoprotein 6
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
107 SERF2interactor21.00004F5 (PF04419, IPR007513): 4F5 protein family
108 SF3A3interactor70.4766.467DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449)
SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
109 SF3B2interactor70.4299.733DUF382 (PF04037, IPR007180): Domain of unknown function (DUF382)
PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region
PSP (PF04046, IPR006568, SM00581): PSP
SAP (PF02037, IPR003034, SM00513): SAP domain
Usp (PF00582, IPR006016): Universal stress protein family
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
Vma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
110 SF3B3interactor110.34529.000CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
111 SF3B5interactor31.0000SF3b10 (PF07189, IPR009846): Splicing factor 3B subunit 10 (SF3b10)
112 SFNsuppressor80.4298.43314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
113 SHFM1interactor220.65851.360CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
114 SIRT1suppressor100.50010.519DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
115 SLX1Binteractor140.8358.301GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
116 SMURF1interactor120.45516.311C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
117 SNAPC1interactor30.6671.000SNAPc_SNAP43 (PF09808, IPR019188): Small nuclear RNA activating complex (SNAPc), subunit SNAP43
118 SNAPC3oncoprotein21.0000zf-SNAP50_C (PF12251, IPR022042): snRNA-activating protein of 50kDa MW C terminal
119 SNAPC4interactor21.0000DUF111 (PF01969, IPR002822): Protein of unknown function DUF111
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
120 SPG7oncoprotein21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
AAA_22 (PF13401, IPR003593): AAA domain
121 SRRTinteractor70.4767.425ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3546 (PF12066, IPR021933): Domain of unknown function (DUF3546)
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
122 SRSF2oncoprotein120.41821.201RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
123 STRBPinteractor100dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
DZF (PF07528, IPR006561, SM00572): DZF domain
124 TADA2Ainteractor120.28839.300SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
125 TAF1Dinteractor30.6671.000TAF1D (PF15333, IPR027976): TATA box-binding protein-associated factor 1D
126 TBXA2Rinteractor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
127 THAP11interactor50.5002.143THAP (PF05485, IPR006612, SM00980): THAP domain
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
MRP-S31 (PF15433, IPR026299): Mitochondrial 28S ribosomal protein S31
FAM76 (PF16046, IPR032017): FAM76 protein
128 TNFAIP8L1oncoprotein100DUF758 (PF05527, IPR008477): Domain of unknown function (DUF758)
129 TP53suppressor310.244231.111DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
130 TRIM33oncoprotein41.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
Spectrin (PF00435, IPR002017): Spectrin repeat
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
131 TRMT6interactor21.0000Gcd10p (PF04189, IPR007316): Gcd10p family
Presenilin (PF01080, IPR001108): Presenilin
INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus
132 TSHZ3interactor100LMP (PF04778, IPR006864): LMP repeated region
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
133 TSR1interactor30.6670.400AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
134 TUBGCP3interactor60.4672.598Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
135 TXN2interactor21.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
136 UBCprotein found in more fusions350.463147.741ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
137 UBE2Iinteractor150.36340.282UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
138 USP43interactor30.6671.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
139 VCAM1interactor170.54431.915C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
140 WDR25interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
141 WDR48suppressor50.6001.204WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
142 YEATS2interactor60.6004.333YEATS (PF03366, IPR005033): YEATS family
143 YWHAQinteractor160.23366.82314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
144 ZBTB9interactor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
PRIMA1 (PF16101): Proline-rich membrane anchor 1
145 ZCCHC10interactor50.5005.000Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-CCHC_3 (PF13917): Zinc knuckle
146 ZKSCAN1interactor21.0000CDC45 (PF02724, IPR003874): CDC45-like protein
KRAB (PF01352, IPR001909, SM00349): KRAB box
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
147 ZNF324interactor21.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
148 ZNF526interactor21.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
149 ZNF891interactor100zf-RING_7 (PF02591, IPR003743): C4-type zinc ribbon domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
OrfB_Zn_ribbon (PF07282, IPR010095): Putative transposase DNA-binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3268 (PF11672, IPR021686): zinc-finger-containing domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
150 ZZZ3interactor50.7003.000Cript (PF10235, IPR019367): Microtubule-associated protein CRIPT
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type

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