Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PSMC2 (from a repository: Fri Nov 11 22:42:09 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 149 The number (and %) of the onco-proteins 47 (31.54 %) The number (and %) of the tumor suppressors 5 (3.36 %) Total number of binary PPIs (saturation %) 2215 (20.09 %) The number (and %) of affected PPIs 149 (6.73 %) The number of possible different fusions 28 PPI diameter 2 PPI radius 1 The average degree of PPI 28.940 Assortativity coefficient -0.1176 The network average Clustering coefficient 0.603 The number (and %) of a zero Clustering coefficients 2 (1.34 %) The number (and %) of a zero Betweenness Centrality 10 (6.71 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PSMC2	All fusions : BM983260;
Proteins found in more fusions	GRK5 (see 2 fusions); PSMB3 (see 1 fusions); GRB2 (see 1 fusions); UBQLN1 (see 2 fusions); PSMB7 (see 2 fusions); NDC80 (see 1 fusions); PSMA7 (see 2 fusions); MAP3K5 (see 1 fusions); SNW1 (see 1 fusions); TRAF6 (see 1 fusions); HUWE1 (see 2 fusions); VPS26A (see 1 fusions); SNRNP200 (see 3 fusions); BAG3 (see 4 fusions); FKBP8 (see 1 fusions); PSMC5 (see 2 fusions); PSMC2 (see 1 fusions); UBE2C (see 1 fusions); CUL3 (see 1 fusions); MYC (see 1 fusions); PSME3 (see 2 fusions); UBC (see 1 fusions); CRY2 (see 3 fusions); SQSTM1 (see 5 fusions); MAPT (see 1 fusions); UBR5 (see 4 fusions); UBQLN2 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PSMC2	parental protein	149	0.185	7643.768	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
2	ABCE1	interactor	18	0.522	17.242	ABC_tran (PF00005, IPR003439): ABC transporter Fer4 (PF00037, IPR001450): 4Fe-4S binding domain RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain AAA_29 (PF13555): P-loop containing region of AAA domain
3	ACADM	oncoprotein	12	0.500	18.942	Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4	ADRM1	interactor	49	0.755	34.685	Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor GET2 (PF08690, IPR028143): GET complex subunit GET2 RPN13_C (PF16550, IPR032368): UCH-binding domain
5	AMBRA1	interactor	32	0.696	28.293	Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Spt20 (PF12090, IPR021950): Spt20 family ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6	AMFR	oncoprotein	24	0.743	17.179	CUE (PF02845, IPR003892, SM00546): CUE domain UbiA (PF01040, IPR000537): UbiA prenyltransferase family zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
7	ATG4C	interactor	6	0.733	1.107	Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
8	ATXN7	interactor	9	0.667	5.140	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain Macoilin (PF09726, IPR019130): Transmembrane protein DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505) IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
9	BAG3	oncoprotein	29	0.619	33.815	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
10	CAD	oncoprotein	28	0.415	62.605	Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain GATase (PF00117, IPR017926): Glutamine amidotransferase class-I MGS (PF02142, IPR011607, SM00851): MGS-like domain OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon
11	CANX	interactor	17	0.419	28.816	Calreticulin (PF00262, IPR001580): Calreticulin family DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
12	CCDC74B	interactor	20	1.000	0	CCDC92 (PF14916): Coiled-coil domain of unknown function CCDC74_C (PF14917, IPR029422): Coiled coil protein 74, C terminal
13	CCT2	interactor	33	0.430	71.628	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
14	CCT3	interactor	33	0.453	70.528	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15	CCT4	interactor	28	0.437	48.565	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
16	CCT6A	interactor	25	0.537	30.887	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17	CCT6B	interactor	11	0.655	5.640	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18	CCT8	interactor	26	0.505	34.145	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
19	CDC5L	interactor	35	0.453	84.211	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
20	CIITA	oncoprotein	7	0.429	4.467	NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
21	CLIP1	oncoprotein	2	1.000	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain CP12 (PF02672, IPR003823, SM01093): CP12 domain DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) FliJ (PF02050, IPR012823): Flagellar FliJ protein Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain SlyX (PF04102, IPR007236): SlyX ApoO (PF09769, IPR019166): Apolipoprotein O Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Leu_zip (PF15294): Leucine zipper CLIP1_ZNF (PF16641, IPR032108): CLIP1 zinc knuckle PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
22	COX7A2	interactor	1	0	0	COX7a (PF02238, IPR003177): Cytochrome c oxidase subunit VII
23	CRY2	protein found in more fusions	19	0.464	17.004	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
24	CUL3	protein found in more fusions	47	0.274	300.850	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
25	DCTN2	interactor	20	0.556	21.136	Dynamitin (PF04912): Dynamitin
26	DNAJA1	interactor	27	0.481	47.985	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
27	DNAJA4	interactor	14	0.571	8.983	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
28	FBXO6	interactor	28	0.389	59.269	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
29	FKBP8	protein found in more fusions	33	0.891	11.886	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
30	FTSJ3	interactor	8	0.536	3.463	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase M16C_assoc (PF08367, IPR013578): Peptidase M16C associated Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381) RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
31	GFPT1	interactor	15	0.438	21.102	SIS (PF01380, IPR001347): SIS domain GATase_6 (PF13522): Glutamine amidotransferase domain
32	GRB2	oncoprotein	19	0.412	22.393	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
33	GRK5	protein found in more fusions	9	0.536	3.353	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
34	GTF2B	interactor	7	0.429	5.187	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
35	GTF2F1	interactor	9	0.417	10.632	TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
36	GTF2H1	oncoprotein	5	0.700	1.733	BSD (PF03909, IPR005607, SM00751): BSD domain PH_TFIIH (PF08567, IPR013876): TFIIH p62 subunit, N-terminal domain
37	HERC3	interactor	12	0.530	8.844	RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
38	HSPA4	interactor	25	0.283	91.793	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
39	HUWE1	oncoprotein	57	0.470	260.336	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
40	INSIG2	interactor	18	0.712	8.430	INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
41	IPO4	interactor	8	0.500	2.131	HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis UME (PF08064, IPR012993, SM00802): UME (NUC010) domain HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
42	KIAA0368	interactor	26	0.600	42.174	HEAT (PF02985, IPR000357): HEAT repeat IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) CLASP_N (PF12348, IPR024395): CLASP N terminal MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal Ecm29 (PF13001, IPR024372): Proteasome stabiliser HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
43	KPNA6	interactor	4	0.833	0.182	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
44	LDHA	interactor	16	0.410	24.977	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
45	LDHB	interactor	16	0.476	28.107	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
46	MAP3K5	oncoprotein	8	0.714	0.949	Pkinase (PF00069, IPR000719): Protein kinase domain DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
47	MAPT	protein found in more fusions	7	0.867	0.268	Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
48	MCFD2	interactor	10	0.867	0.932	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
49	MID1	oncoprotein	17	0.792	5.728	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain SPRY (PF00622, IPR003877, SM00449): SPRY domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
50	MID2	interactor	10	0.722	1.970	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
51	MRPS16	interactor	5	1.000	0	Ribosomal_S16 (PF00886, IPR000307): Ribosomal protein S16 FtsK_4TM (PF13491, IPR025199): 4TM region of DNA translocase FtsK/SpoIIIE
52	MTCH1	interactor	11	0.873	1.488	YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
53	MTMR1	interactor	1	0	0	GRAM (PF02893, IPR004182, SM00568): GRAM domain Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain 3-PAP (PF12578, IPR022587): Myotubularin-associated protein Myb_CC_LHEQLE (PF14379, IPR025756): MYB-CC type transfactor, LHEQLE motif
54	MYC	oncoprotein	39	0.411	154.515	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
55	NDC80	protein found in more fusions	8	0.667	2.198	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Ndc80_HEC (PF03801, IPR005550): HEC/Ndc80p family SlyX (PF04102, IPR007236): SlyX ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
56	NDRG1	suppressor	10	0.378	9.140	Ndr (PF03096, IPR004142): Ndr family
57	NEURL4	interactor	3	0.667	0.250	Neuralized (PF07177, IPR006573, SM00588): Neuralized
58	NFS1	interactor	3	1.000	0	Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
59	NOS2	interactor	36	0.652	38.556	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
60	NTRK1	oncoprotein	78	0.278	948.575	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
61	NXF1	interactor	29	0.312	117.151	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
62	PAAF1	interactor	23	0.964	0.629	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
63	PARK2	suppressor	54	0.586	154.447	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
64	PCDH10	suppressor	2	1.000	0	Cadherin_2 (PF08266, IPR013164): Cadherin-like K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Cadherin (PF00028, IPR002126, SM00112): Cadherin domain Cadherin_3 (PF16184): Cadherin-like Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
65	PCK1	interactor	20	0.553	21.822	PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
66	PMS2	oncoprotein	9	0.611	5.093	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain MORN_2 (PF07661, IPR011652): MORN repeat variant MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
67	POLR2M	interactor	3	0.667	0.667	GCOM2 (PF15328, IPR026213): Putative GRINL1B complex locus protein 2
68	POMP	interactor	23	0.784	15.191	UMP1 (PF05348, IPR008012): Proteasome maturation factor UMP1
69	PSMA1	interactor	60	0.624	136.997	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
70	PSMA2	interactor	65	0.596	129.237	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
71	PSMA3	interactor	63	0.595	199.768	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
72	PSMA4	interactor	53	0.706	62.348	Proteasome (PF00227, IPR001353): Proteasome subunit U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34 Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
73	PSMA5	oncoprotein	61	0.592	149.135	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
74	PSMA6	interactor	63	0.592	155.914	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
75	PSMA7	protein found in more fusions	57	0.682	77.803	Proteasome (PF00227, IPR001353): Proteasome subunit Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
76	PSMA8	interactor	31	0.974	0.936	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature Myb_DNA-bind_5 (PF13873, IPR028002): Myb/SANT-like DNA-binding domain
77	PSMB1	interactor	51	0.749	37.127	Proteasome (PF00227, IPR001353): Proteasome subunit
78	PSMB2	interactor	49	0.747	60.323	Proteasome (PF00227, IPR001353): Proteasome subunit
79	PSMB3	protein found in more fusions	50	0.765	33.021	Proteasome (PF00227, IPR001353): Proteasome subunit
80	PSMB4	interactor	50	0.740	43.212	Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Proteasome (PF00227, IPR001353): Proteasome subunit
81	PSMB5	interactor	53	0.679	84.032	Proteasome (PF00227, IPR001353): Proteasome subunit
82	PSMB6	interactor	46	0.796	33.451	DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502) Proteasome (PF00227, IPR001353): Proteasome subunit
83	PSMB7	protein found in more fusions	49	0.808	21.842	Proteasome (PF00227, IPR001353): Proteasome subunit Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
84	PSMB8	interactor	41	0.882	11.666	Proteasome (PF00227, IPR001353): Proteasome subunit
85	PSMB9	interactor	40	0.907	5.843	Proteasome (PF00227, IPR001353): Proteasome subunit
86	PSMC1	interactor	75	0.452	462.906	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) DivIC (PF04977, IPR007060): Septum formation initiator DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815) Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
87	PSMC3	interactor	75	0.454	434.896	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
88	PSMC4	interactor	74	0.467	378.286	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) NTPase_1 (PF03266, IPR004948): NTPase CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_16 (PF13191): AAA ATPase domain
89	PSMC5	protein found in more fusions	79	0.443	448.044	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Laminin_II (PF06009, IPR010307): Laminin Domain II RILP (PF11461, IPR021563): Rab interacting lysosomal protein AAA_16 (PF13191): AAA ATPase domain
90	PSMC6	interactor	69	0.514	247.385	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily) TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
91	PSMD1	interactor	66	0.560	168.323	PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat HEAT_2 (PF13646): HEAT repeats
92	PSMD10	interactor	29	0.766	22.536	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
93	PSMD11	interactor	62	0.567	176.864	DUF247 (PF03140, IPR004158): Plant protein of unknown function PCI (PF01399, IPR000717, SM00088): PCI domain AAA_16 (PF13191): AAA ATPase domain TPR_12 (PF13424): Tetratricopeptide repeat
94	PSMD12	interactor	65	0.569	153.242	Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain PCI (PF01399, IPR000717, SM00088): PCI domain
95	PSMD13	interactor	59	0.621	105.895	Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase PCI (PF01399, IPR000717, SM00088): PCI domain
96	PSMD14	interactor	65	0.576	184.775	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
97	PSMD2	oncoprotein	78	0.434	456.507	PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat THAP (PF05485, IPR006612, SM00980): THAP domain HEAT_2 (PF13646): HEAT repeats
98	PSMD3	interactor	70	0.492	276.623	Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat PCI (PF01399, IPR000717, SM00088): PCI domain Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
99	PSMD4	interactor	65	0.536	235.793	UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
100	PSMD5	interactor	40	0.865	18.715	Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
101	PSMD6	interactor	55	0.703	55.574	RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7 PCI (PF01399, IPR000717, SM00088): PCI domain
102	PSMD7	interactor	59	0.622	134.562	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function Auts2 (PF15336): Autism susceptibility gene 2 protein Coilin_N (PF15862, IPR031722): Coilin N-terminus
103	PSMD8	interactor	55	0.697	59.312	CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
104	PSMD9	interactor	21	0.943	1.024	Remorin_C (PF03763, IPR005516): Remorin, C-terminal region DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046) PDZ_2 (PF13180, IPR001478): PDZ domain
105	PSME1	interactor	30	0.840	9.223	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
106	PSME2	interactor	29	0.892	3.190	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
107	PSME3	protein found in more fusions	30	0.783	20.395	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
108	RAB5C	oncoprotein	6	0.600	2.111	Ras (PF00071, IPR001806, SM00173): Ras family
109	RAD21	oncoprotein	17	0.493	19.458	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
110	RAD23A	oncoprotein	47	0.711	107.095	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
111	RAD23B	suppressor	27	0.687	27.338	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
112	RELA	oncoprotein	15	0.407	27.262	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
113	RNF185	interactor	15	0.692	4.682	zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
114	RNF2	interactor	26	0.277	76.092	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
115	RPN1	oncoprotein	22	0.390	56.340	Ribophorin_I (PF04597, IPR007676): Ribophorin I CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
116	RPS21	interactor	14	0.769	4.236	Ribosomal_S21e (PF01249, IPR001931): Ribosomal protein S21e
117	RPS6KB2	interactor	16	0.425	13.679	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
118	SEC23A	interactor	12	0.409	13.105	Gelsolin (PF00626, IPR007123): Gelsolin repeat Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
119	SHFM1	interactor	42	0.656	58.781	CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
120	SHMT2	interactor	10	0.489	8.563	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
121	SIRT7	interactor	26	0.320	67.192	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
122	SKIL	suppressor	3	1.000	0	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
123	SMC1A	oncoprotein	13	0.545	11.920	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
124	SMC3	oncoprotein	11	0.600	9.156	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
125	SNRNP200	protein found in more fusions	16	0.467	10.377	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603 Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
126	SNW1	protein found in more fusions	36	0.417	115.002	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
127	SPRTN	interactor	9	0.500	4.689	GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term SprT-like (PF10263, IPR006640, SM00731): SprT-like family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
128	SQSTM1	oncoprotein	22	0.400	39.749	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
129	SUCLA2	interactor	5	0.700	2.333	ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain Ligase_CoA (PF00549, IPR005811): CoA-ligase nsp7 (PF08716, IPR014828): nsp7 replicase
130	TBP	interactor	9	0.464	7.886	TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
131	TPM4	oncoprotein	8	0.857	0.539	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
132	TRAF6	protein found in more fusions	19	0.523	23.667	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
133	TRIM5	interactor	8	0.667	1.292	Baculo_IE-1 (PF05290, IPR007954): Baculovirus immediate-early protein (IE-0) Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
134	TUBB	interactor	24	0.370	70.495	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
135	TXNL1	interactor	26	0.772	11.818	PITH (PF06201, IPR010400): PITH domain Thioredoxin (PF00085, IPR013766): Thioredoxin
136	UBC	protein found in more fusions	71	0.358	589.176	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
137	UBE2C	oncoprotein	10	0.722	2.446	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
138	UBQLN1	protein found in more fusions	24	0.534	39.776	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X
139	UBQLN2	protein found in more fusions	18	0.485	32.712	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family SUZ (PF12752, IPR024771): SUZ domain Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
140	UBR2	interactor	4	0.500	1.750	ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
141	UBR5	protein found in more fusions	13	0.394	11.472	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SDA1 (PF05285, IPR007949): SDA1 HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
142	UCHL5	oncoprotein	51	0.739	35.832	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
143	UFC1	interactor	2	1.000	0	UFC1 (PF08694, IPR014806): Ubiquitin-fold modifier-conjugating enzyme 1
144	USP14	interactor	31	0.789	26.054	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
145	VBP1	interactor	2	1.000	0	Prefoldin (PF02996, IPR004127): Prefoldin subunit
146	VPS26A	protein found in more fusions	5	0.833	0.200	Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
147	XPO1	interactor	28	0.220	147.787	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
148	YBX1	oncoprotein	20	0.374	33.188	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
149	ZCCHC8	interactor	11	0.582	4.838	Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein PSP (PF04046, IPR006568, SM00581): PSP zf-CCHC (PF00098, IPR001878): Zinc knuckle DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)

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