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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)80
The number (and %) of the onco-proteins17 (21.25 %)
The number (and %) of the tumor suppressors4 (5.00 %)
Total number of binary PPIs (saturation %)1201 (38.01 %)
The number (and %) of affected PPIs80 (6.66 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI29.175
Assortativity coefficient-0.2688
The network average Clustering coefficient0.782
The number (and %) of a zero Clustering coefficients4 (5.00 %)
The number (and %) of a zero Betweenness Centrality15 (18.75 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PSMB7 All fusions
: W23061; BQ424626;
Proteins found in more fusions PSMC2 (see 1 fusions); PSMB3 (see 1 fusions); PSMB7 (see 2 fusions); PSMA7 (see 2 fusions); HTT (see 1 fusions); UBC (see 1 fusions); HUWE1 (see 2 fusions); PSMB7/FUS (see 1 fusions); FKBP8 (see 1 fusions); PSMC5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PSMB7parental protein800.3531690.020Proteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
2 ACACAinteractor70.4764.757ACC_central (PF08326, IPR013537): Acetyl-CoA carboxylase, central region
Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
3 ADRM1interactor400.9185.424Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor
GET2 (PF08690, IPR028143): GET complex subunit GET2
RPN13_C (PF16550, IPR032368): UCH-binding domain
4 AFPinteractor100Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
5 AMFRoncoprotein240.77125.105CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
6 AURKAoncoprotein100.6676.133Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
7 C11orf58interactor21.0000DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
8 CASToncoprotein70.9050.468Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
Calpain_inhib (PF00748, IPR001259): Calpain inhibitor
Maf_N (PF08383, IPR013592): Maf N-terminal region
9 CBX8interactor200Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
10 CLIC4oncoprotein71.0000GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
11 EPB41L1interactor90.7782.9054_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
12 FBXO7interactor90.7501.719Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
F-box-like (PF12937, IPR001810): F-box-like
13 FKBP8protein found in more fusions310.9860.373FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
14 FUSsuppressor60.6002.836Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
15 HECW2interactor51.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
16 HTTprotein found in more fusions60.6000.540HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
17 HUWE1oncoprotein370.72480.037BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
18 IQCB1interactor141.0000DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
19 KIF5Binteractor130.6678.423ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3
DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
20 NAA25interactor100BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
NatB_MDM20 (PF09797, IPR019183): N-acetyltransferase B complex (NatB) non catalytic subunit
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
21 NOS2interactor271.0000FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
22 NUDCD2interactor21.0000CS (PF04969, IPR007052): CS domain
DUF3110 (PF11360, IPR021503): Protein of unknown function (DUF3110)
23 PARK2suppressor430.78251.743IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
24 PCK1interactor140.9670.184PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
25 PCMT1interactor50.7000.936PCMT (PF01135, IPR000682): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
26 PLK1suppressor140.9232.000Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
27 POLR1Cinteractor21.0000RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
28 POMPinteractor220.9143.393UMP1 (PF05348, IPR008012): Proteasome maturation factor UMP1
29 PSMA1interactor580.622136.973Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
30 PSMA2interactor590.619122.447Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
31 PSMA3interactor550.68674.938Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
32 PSMA4interactor510.72256.608Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
33 PSMA5oncoprotein600.562240.481Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
34 PSMA6interactor550.655106.632Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
35 PSMA7protein found in more fusions540.68093.657Proteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
36 PSMA8interactor301.0000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
Myb_DNA-bind_5 (PF13873, IPR028002): Myb/SANT-like DNA-binding domain
37 PSMB1interactor520.68981.655Proteasome (PF00227, IPR001353): Proteasome subunit
38 PSMB2interactor480.75589.335Proteasome (PF00227, IPR001353): Proteasome subunit
39 PSMB3protein found in more fusions540.654107.894Proteasome (PF00227, IPR001353): Proteasome subunit
40 PSMB4interactor540.619134.959Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Proteasome (PF00227, IPR001353): Proteasome subunit
41 PSMB5interactor520.665113.586Proteasome (PF00227, IPR001353): Proteasome subunit
42 PSMB6interactor490.74540.932DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502)
Proteasome (PF00227, IPR001353): Proteasome subunit
43 PSMB8interactor400.9235.013Proteasome (PF00227, IPR001353): Proteasome subunit
44 PSMB9interactor450.75347.384Proteasome (PF00227, IPR001353): Proteasome subunit
45 PSMC1interactor460.84515.871AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
46 PSMC2protein found in more fusions490.80823.052AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
47 PSMC3interactor450.87710.889AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
48 PSMC4interactor470.81334.771AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NTPase_1 (PF03266, IPR004948): NTPase
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
AAA_16 (PF13191): AAA ATPase domain
49 PSMC5protein found in more fusions490.79149.903AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
50 PSMC6interactor440.86525.391AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
51 PSMD1interactor450.86013.541PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
52 PSMD11interactor410.9353.702DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
53 PSMD12interactor450.85332.222Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
54 PSMD13interactor430.88410.322Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase
PCI (PF01399, IPR000717, SM00088): PCI domain
55 PSMD14interactor490.77371.329JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
56 PSMD2oncoprotein470.78943.038PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
57 PSMD3interactor440.84826.838Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
58 PSMD4interactor420.9126.293UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
59 PSMD5interactor360.9780.873Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
60 PSMD6interactor460.81736.338RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
61 PSMD7interactor450.85714.197JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
62 PSMD8interactor410.9353.753CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
63 PSME1interactor280.9005.053PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
64 PSME2interactor260.9800.419PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
65 PSME4interactor160.9750.266Filament (PF00038, IPR001664): Intermediate filament protein
HEAT (PF02985, IPR000357): HEAT repeat
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
BLM10_mid (PF16507, IPR032430): Proteasome-substrate-size regulator, mid region
66 PSMF1interactor90.8570.794PI31_Prot_C (PF08577, IPR013886): PI31 proteasome regulator
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
67 PSMG1interactor110.9560.254PAC1 (PF16094, IPR016565): Proteasome assembly chaperone 4
68 PSMG2interactor210.76711.871PAC2 (PF09754, IPR019151): PAC2 family
69 PSMG3interactor130.9231.033PAC3 (PF10178, IPR018788): Proteasome assembly chaperone 3
70 PYGLinteractor60.9000.065Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
71 RAD23Aoncoprotein420.79659.692UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
72 RAD23Bsuppressor190.9770.234K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
73 S100A9oncoprotein31.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
74 SERPINA10interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
75 SYAP1interactor41.0000Arg_tRNA_synt_N (PF03485, IPR005148, SM01016): Arginyl tRNA synthetase N terminal domain
BSD (PF03909, IPR005607, SM00751): BSD domain
UPF0052 (PF01933, IPR002882): Uncharacterised protein family UPF0052
DUF2340 (PF10209, IPR018794): Uncharacterized conserved protein (DUF2340)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
76 SYVN1interactor180.8756.705Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
77 TMOD3interactor51.0000Tropomodulin (PF03250, IPR004934): Tropomodulin
Usher (PF00577, IPR000015): Outer membrane usher protein
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
78 UBCprotein found in more fusions410.647132.990ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
79 UBE2D1interactor50.8330.133UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
80 UCHL5oncoprotein400.9274.677Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1

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