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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PSAP (from a repository: Mon Nov 14 12:25:14 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins11 (26.83 %)
The number (and %) of the tumor suppressors3 (7.32 %)
Total number of binary PPIs (saturation %)98 (11.95 %)
The number (and %) of affected PPIs41 (41.84 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.951
Assortativity coefficient-0.3751
The network average Clustering coefficient0.663
The number (and %) of a zero Clustering coefficients4 (9.76 %)
The number (and %) of a zero Betweenness Centrality20 (48.78 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: PSAP All fusions
: BE698722; BG236863; BE930210; BE176600; BF733880; AA632698;
Proteins found in more fusions VPS35 (see 2 fusions); PSAP (see 6 fusions); SNAP23 (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PSAPparental protein410.0531403.500SapA (PF02199, IPR003119, SM00162): Saposin A-type domain
SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
SapB_2 (PF03489, IPR008138): Saposin-like type B, region 2
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
2 BAG3oncoprotein31.0000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
3 BCAT1interactor21.0000Aminotran_4 (PF01063, IPR001544): Amino-transferase class IV
4 BRCA1suppressor70.3339.667BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
5 C1QBPinteractor31.0000MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
6 CELSR1interactor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Cadherin_3 (PF16184): Cadherin-like
GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
7 CFTRsuppressor50.5002.667ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
8 COPS6interactor41.0000DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
9 CTSDinteractor40.5003.000A1_Propeptide (PF07966, IPR012848): A1 Propeptide
Asp (PF00026, IPR001461): Eukaryotic aspartyl protease
10 DNAJA1interactor40.5002.667DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
11 ERBB2oncoprotein31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
12 FBXO6interactor80.28620.000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
13 GDAP1interactor100SyrA (PF11089, IPR024239): Exopolysaccharide production repressor
GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
DUF4296 (PF14129, IPR025381): Domain of unknown function (DUF4296)
14 GTF2F1interactor40.5003.000TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
15 LAMB2interactor30.6671.000APG6 (PF04111, IPR007243): Autophagy protein Apg6
DivIC (PF04977, IPR007060): Septum formation initiator
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
RecX (PF02631, IPR003783): RecX family
Vps53_N (PF04100, IPR007234): Vps53-like, N-terminal
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
16 MAFFinteractor200bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
17 MVPoncoprotein31.0000Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
18 NLGN3interactor21.0000COesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
19 NUP133oncoprotein21.0000Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal
20 PLAURoncoprotein30.6671.000Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
21 SAP18interactor60.4676.667SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
22 SGK223interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Serglycin (PF04360, IPR007455): Serglycin
23 SMAD2suppressor40.6671.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
24 SMAD9interactor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
25 SMARCC2interactor50.4005.500GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
26 SNAP23protein found in more fusions31.0000DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SNAP-25 (PF00835, IPR000928): SNAP-25 family
DUF5089 (PF17002, IPR031547): Domain of unknown function (DUF5089)
27 SNCAinteractor31.0000Synuclein (PF01387, IPR001058): Synuclein
28 SNRPA1interactor50.4005.000LRR_9 (PF14580): Leucine-rich repeat
29 SRSF5interactor40.8330.667DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
30 SSR1interactor21.0000TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
31 SUMO2interactor40.6671.000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
32 SURF4interactor40.6672.000SURF4 (PF02077, IPR002995): SURF4 family
33 TCERG1interactor21.0000FF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family
34 THRAP3oncoprotein30.6670.500API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
35 U2AF1oncoprotein40.6671.500DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509)
KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
36 UBE3Aoncoprotein60.4005.667HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
37 USP4oncoprotein200UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
38 USP48interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-trcl (PF13451, IPR025306): Probable zinc-ribbon domain
39 VPS29interactor30.6671.000Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
40 VPS35protein found in more fusions40.6671.000FerA (PF08165, IPR012560): FerA (NUC095) domain
Vps35 (PF03635, IPR005378): Vacuolar protein sorting-associated protein 35
41 ZBED1interactor31.0000Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 PSAPparental proteinSapA (PF02199, IPR003119, SM00162): Saposin A-type domain
SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
SapB_2 (PF03489, IPR008138): Saposin-like type B, region 2
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
BE176600, BE698722, BE930210

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