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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRPS2 (from a repository: Sat Nov 19 13:52:37 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins5 (26.32 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)34 (19.88 %)
The number (and %) of affected PPIs19 (55.88 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.947
Assortativity coefficient-0.1496
The network average Clustering coefficient0.512
The number (and %) of a zero Clustering coefficients7 (36.84 %)
The number (and %) of a zero Betweenness Centrality15 (78.95 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PRPS2 All fusions
: BE767033;
Proteins found in more fusions PRPS2 (see 2 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PRPS2parental protein190.065269.000Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
2 ARMC9interactor100CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
AP3D1 (PF06375): AP-3 complex subunit delta-1
3 BAG3oncoprotein200BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
4 C18orf8interactor100Mic1 (PF07035, IPR009755): Colon cancer-associated protein Mic1-like
5 ELAVL1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 FAM96Ainteractor100DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
7 FN1oncoprotein21.0000fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
8 GTF2Iinteractor100GTF2I (PF02946, IPR004212): GTF2I-like repeat
9 NMT2interactor21.0000NMT (PF01233, IPR022676): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
NMT_C (PF02799, IPR022677): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
10 NOTCH2NLinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
11 PPATinteractor21.0000Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
12 PRIM2interactor21.0000DNA_primase_lrg (PF04104, IPR007238): Eukaryotic and archaeal DNA primase, large subunit
13 PRPS1oncoprotein80.33314.000Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
14 PRPSAP1interactor41.0000Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
15 PRPSAP2interactor40.6672.000Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
16 SBDSoncoprotein21.0000SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
17 TCTN1interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
18 UBXN1interactor31.0000Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
19 WDYHV1interactor100Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase

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