Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRPF6 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 87 The number (and %) of the onco-proteins 23 (26.44 %) The number (and %) of the tumor suppressors 6 (6.90 %) Total number of binary PPIs (saturation %) 967 (25.85 %) The number (and %) of affected PPIs 87 (9.00 %) The number of possible different fusions 14 PPI diameter 2 PPI radius 1 The average degree of PPI 21.494 Assortativity coefficient -0.1481 The network average Clustering coefficient 0.545 The number (and %) of a zero Clustering coefficients 2 (2.30 %) The number (and %) of a zero Betweenness Centrality 3 (3.45 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PRPF6	All fusions : AI620966;
Proteins found in more fusions	LUC7L2 (see 2 fusions); PRPF19 (see 2 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); MYC (see 1 fusions); SNRNP200 (see 3 fusions); PRPF8 (see 3 fusions); PRPF6 (see 1 fusions); RPA1 (see 1 fusions); TP53 (see 3 fusions); PRPF3 (see 1 fusions); SNW1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PRPF6	parental protein	87	0.232	2233.674	PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal Suf (PF05843, IPR008847): Suppressor of forked protein (Suf) TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
2	ACIN1	interactor	20	0.547	17.857	Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family FAM27 (PF15832, IPR031672): FAM27 D and E protein family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746) RSB_motif (PF16294, IPR032552): RNSP1-SAP18 binding (RSB) motif SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
3	AR	oncoprotein	8	0.381	7.450	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
4	ARAF	oncoprotein	3	0.667	0.667	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
5	BSG	interactor	6	0.733	1.936	Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
6	CCDC8	interactor	17	0.533	16.791	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
7	CD2BP2	interactor	13	0.833	2.458	GYF (PF02213, IPR003169, SM00444): GYF domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
8	CDC5L	interactor	43	0.494	127.391	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
9	CTNNB1	oncoprotein	10	0.333	11.442	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
10	CUL7	protein found in more fusions	42	0.451	117.716	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
11	DDX18	interactor	8	0.357	3.875	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217)
12	DDX23	interactor	30	0.492	66.695	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase FUSC (PF04632, IPR006726): Fusaric acid resistance protein family Transformer (PF06495, IPR010519): Fruit fly transformer protein Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF3698 (PF12479, IPR022167): Protein of unknown function (DUF3698) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
13	EED	suppressor	31	0.448	81.514	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
14	EFTUD2	interactor	39	0.499	82.016	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
15	EIF4A3	interactor	32	0.632	30.465	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
16	GCFC2	interactor	7	0.619	3.770	DUF1676 (PF07898, IPR012464): Protein of unknown function (DUF1676) GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
17	GIGYF2	interactor	9	0.500	8.043	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) GYF (PF02213, IPR003169, SM00444): GYF domain Macoilin (PF09726, IPR019130): Transmembrane protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 DUF3801 (PF12687, IPR024234): Protein of unknown function (DUF3801) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term AAA_23 (PF13476): AAA domain ARGLU (PF15346): Arginine and glutamate-rich 1 PRTase_3 (PF15610, IPR028944): PRTase ComF-like Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
18	HDAC11	interactor	11	0.509	9.638	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
19	HNRNPM	interactor	38	0.430	121.271	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
20	IK	interactor	23	0.463	35.461	Lsm_interact (PF05391, IPR008669): Lsm interaction motif RED_C (PF07807, IPR012492): RED-like protein C-terminal region RED_N (PF07808, IPR012916): RED-like protein N-terminal region PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
21	KIF21B	interactor	1	0	0	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) Thioredoxin_4 (PF13462, IPR012336): Thioredoxin BORG_CEP (PF14957, IPR029273): Cdc42 effector TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
22	LUC7L2	protein found in more fusions	21	0.595	12.918	LUC7 (PF03194, IPR004882): LUC7 N_terminus Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
23	MEPCE	interactor	20	0.616	12.921	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
24	MEX3C	interactor	3	1.000	0	KH_1 (PF00013, IPR004088, SM00322): KH domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
25	MMS19	interactor	8	0.500	8.427	DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
26	MYC	oncoprotein	13	0.424	19.877	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
27	NCSTN	interactor	14	0.473	18.714	Nicastrin (PF05450, IPR008710): Nicastrin Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
28	NOTCH1	oncoprotein	8	0.571	3.352	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
29	NPM1	oncoprotein	20	0.398	27.847	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
30	NTRK1	oncoprotein	47	0.340	276.958	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
31	OBSL1	interactor	45	0.439	162.206	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
32	PARK2	suppressor	9	0.464	6.127	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33	PASK	interactor	3	0.667	0.286	Pkinase (PF00069, IPR000719): Protein kinase domain PAS_8 (PF13188, IPR000014): PAS domain PAS_9 (PF13426, IPR000014): PAS domain
34	PRPF19	protein found in more fusions	41	0.512	100.315	Prp19 (PF08606, IPR013915): Prp19/Pso4-like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
35	PRPF3	protein found in more fusions	36	0.516	83.920	DUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115) PRP3 (PF08572, IPR013881): pre-mRNA processing factor 3 (PRP3) PWI (PF01480, IPR002483, SM00311): PWI domain TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
36	PRPF31	interactor	26	0.653	19.588	Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
37	PRPF4	interactor	25	0.685	20.790	PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
38	PRPF4B	oncoprotein	19	0.690	8.506	Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking Ureide_permease (PF07168, IPR009834): Ureide permease Pkinase (PF00069, IPR000719): Protein kinase domain Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
39	PRPF8	oncoprotein	51	0.403	283.627	PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain PROCN (PF08083, IPR012592): PROCN (NUC071) domain PROCT (PF08084, IPR012984): PROCT (NUC072) domain RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8 U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8 U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8 JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
40	RAB4B	oncoprotein	3	0.667	0.077	Ras (PF00071, IPR001806, SM00173): Ras family
41	RAF1	oncoprotein	6	0.600	2.900	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
42	RBM14	suppressor	22	0.398	39.812	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
43	RNPS1	interactor	30	0.483	54.056	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) Macoilin (PF09726, IPR019130): Transmembrane protein
44	RNU11	interactor	9	0.889	0.376	NA
45	RNU12	interactor	9	0.889	0.376	NA
46	RPA1	suppressor	21	0.679	10.155	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
47	RPA2	oncoprotein	17	0.632	8.614	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
48	RPA3	interactor	16	0.733	4.121	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
49	RPS13	interactor	12	0.621	5.377	Ribosomal_S13_N (PF08069, IPR012606): Ribosomal S13/S15 N-terminal domain Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
50	RPS24	interactor	12	0.591	5.857	Fascin (PF06268, IPR022768): Fascin domain Ribosomal_S24e (PF01282, IPR001976): Ribosomal protein S24e DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
51	SAP18	interactor	18	0.562	12.330	SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
52	SART1	interactor	43	0.503	114.539	SART-1 (PF03343, IPR005011): SART-1 family Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
53	SCARNA22	interactor	9	0.667	3.135	NA
54	SF3A1	interactor	43	0.481	118.512	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
55	SF3A2	interactor	29	0.670	22.273	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
56	SF3A3	interactor	24	0.710	11.596	DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449) SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain Telomere_Sde2_2 (PF13297): Telomere stability C-terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
57	SF3B3	interactor	41	0.521	99.000	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
58	SIRT7	interactor	21	0.433	41.292	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
59	SMARCA2	suppressor	6	0.467	2.719	DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain YL1 (PF05764, IPR008895): YL1 nuclear protein BRK (PF07533, IPR006576, SM00592): BRK domain DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
60	SNRNP200	protein found in more fusions	45	0.446	166.096	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603 Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
61	SNRNP40	interactor	24	0.612	25.452	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
62	SNRPA	interactor	16	0.781	2.986	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
63	SNRPA1	interactor	31	0.645	34.314	LRR_9 (PF14580): Leucine-rich repeat
64	SNRPD1	interactor	31	0.576	45.696	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) LSM (PF01423, IPR001163): LSM domain
65	SNRPD2	interactor	33	0.511	63.770	LSM (PF01423, IPR001163): LSM domain
66	SNRPD3	interactor	25	0.657	20.998	LSM (PF01423, IPR001163): LSM domain
67	SNU13	interactor	23	0.390	45.486	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
68	SNW1	protein found in more fusions	40	0.475	110.268	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
69	SON	interactor	20	0.579	19.518	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region G-patch (PF01585, IPR000467, SM00443): G-patch domain tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1 GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer RSRP (PF17069): Arginine/Serine-Rich protein 1
70	SRRM2	interactor	35	0.576	60.500	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
71	SRSF5	interactor	23	0.648	15.949	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
72	SRSF7	interactor	25	0.640	16.059	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP2 (PF01254, IPR000678): Nuclear transition protein 2 zf-CCHC (PF00098, IPR001878): Zinc knuckle
73	SUPT16H	interactor	21	0.474	22.308	Nop14 (PF04147, IPR007276): Nop14-like family Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Rtt106 (PF08512, IPR013719): Histone chaperone Rttp106-like SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68) Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal FACT-Spt16_Nlob (PF14826, IPR029148): FACT complex subunit SPT16 N-terminal lobe domain
74	TADA2A	interactor	16	0.458	18.002	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
75	THRAP3	oncoprotein	22	0.571	22.405	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228) THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
76	TIMM44	interactor	3	0.667	0.667	Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211) AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3 RecG_N (PF17190): RecG N-terminal helical domain
77	TP53	oncoprotein	21	0.374	44.833	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
78	TPBG	interactor	8	0.500	2.762	LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
79	TRA2A	interactor	22	0.584	19.963	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
80	TSSC4	suppressor	11	0.673	5.515	TSSC4 (PF15264, IPR029338): Tumour suppressing sub-chromosomal transferable candidate 4
81	TXNL4A	interactor	6	0.800	0.736	DIM1 (PF02966, IPR004123): Mitosis protein DIM1
82	TXNL4B	interactor	1	0	0	DIM1 (PF02966, IPR004123): Mitosis protein DIM1
83	U2AF1	oncoprotein	33	0.513	69.599	DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509) KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
84	U2AF2	protein found in more fusions	38	0.563	64.930	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
85	USP39	oncoprotein	30	0.460	86.470	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
86	YWHAB	interactor	10	0.400	17.493	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
87	ZNF326	interactor	11	0.564	5.597	AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) DUF678 (PF05077, IPR007769): Protein of unknown function (DUF678) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated

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