Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRPF40A (from a repository: Sun Dec 4 20:08:25 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 178 The number (and %) of the onco-proteins 55 (30.90 %) The number (and %) of the tumor suppressors 11 (6.18 %) Total number of binary PPIs (saturation %) 1646 (10.45 %) The number (and %) of affected PPIs 178 (10.81 %) The number of possible different fusions 36 PPI diameter 2 PPI radius 1 The average degree of PPI 17.854 Assortativity coefficient -0.2639 The network average Clustering coefficient 0.472 The number (and %) of a zero Clustering coefficients 16 (8.99 %) The number (and %) of a zero Betweenness Centrality 30 (16.85 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PRPF40A	All fusions : BQ318887; BF336471;
Proteins found in more fusions	SDCBP2 (see 1 fusions); TERF2IP (see 1 fusions); SMAD4 (see 2 fusions); STAU1 (see 2 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); PRKAR1A (see 2 fusions); UBQLN1 (see 2 fusions); EWSR1 (see 2 fusions); PIAS1 (see 2 fusions); HTT (see 1 fusions); VCL (see 2 fusions); COPS5 (see 1 fusions); DDX5 (see 1 fusions); DHX8 (see 1 fusions); PRPF40A (see 2 fusions); ZNF451 (see 1 fusions); RPA1 (see 1 fusions); SNW1 (see 1 fusions); HSPB1/OBSL1 (see 1 fusions); YWHAG (see 1 fusions); PUF60 (see 2 fusions); SFPQ (see 6 fusions); HNRNPUL1 (see 1 fusions); PFKL (see 2 fusions); LUC7L (see 1 fusions); FMNL1 (see 1 fusions); PCBP2 (see 3 fusions); SF1 (see 1 fusions); UBQLN2 (see 2 fusions); HSPB1 (see 4 fusions); CSNK2A1 (see 1 fusions); CHD3 (see 1 fusions); GAPDH (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PRPF40A	parental protein	178	0.091	18727.533	FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
2	ABI1	oncoprotein	10	0.444	14.340	Abi_HHR (PF07815, IPR012849): Abl-interactor HHR Cytochrom_B558a (PF05038, IPR007732): Cytochrome Cytochrome b558 alpha-subunit SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124) PRIMA1 (PF16101): Proline-rich membrane anchor 1 ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3	ACIN1	interactor	28	0.503	40.276	Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family FAM27 (PF15832, IPR031672): FAM27 D and E protein family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746) RSB_motif (PF16294, IPR032552): RNSP1-SAP18 binding (RSB) motif SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
4	APBB1IP	interactor	2	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain MLANA (PF14991, IPR029242): Protein melan-A SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
5	ARFGEF2	interactor	3	0.667	0.500	DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
6	ASXL2	interactor	1	0	0	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain HARE-HTH (PF05066, IPR007759): HB1, ASXL, restriction endonuclease HTH domain ASXH (PF13919, IPR028020): Asx homology domain PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx DUF4551 (PF15087, IPR027878): Protein of unknown function (DUF4551)
7	ATAD3A	interactor	8	0.357	4.925	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
8	BAG6	interactor	7	0.667	2.604	DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538) PRIMA1 (PF16101): Proline-rich membrane anchor 1
9	BARD1	suppressor	30	0.234	149.803	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
10	BRD4	oncoprotein	4	0.667	0.582	Caldesmon (PF02029, IPR006018): Caldesmon Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Stm1_N (PF09598, IPR019084): Stm1 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
11	CAP2	interactor	3	1.000	0	CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
12	CCDC9	interactor	3	1.000	0	IncA (PF04156, IPR007285): IncA protein NOA36 (PF06524, IPR010531): NOA36 protein DUF2098 (PF09871, IPR019209): Uncharacterized protein conserved in archaea (DUF2098) MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c DUF4594 (PF15266, IPR029336): Domain of unknown function (DUF4594)
13	CCT2	interactor	14	0.593	6.572	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
14	CCT4	interactor	9	0.778	1.109	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15	CCT7	interactor	8	0.750	1.061	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
16	CDK11A	oncoprotein	5	0.800	0.348	DDHD (PF02862, IPR004177, SM01127): DDHD domain eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Pkinase (PF00069, IPR000719): Protein kinase domain RIO1 (PF01163, IPR018934): RIO1 family DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) DHHW (PF14286, IPR025945): DHHW protein DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
17	CDK12	oncoprotein	9	0.500	6.213	Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) Mem_trans (PF03547, IPR004776): Membrane transport protein Pkinase (PF00069, IPR000719): Protein kinase domain SOBP (PF15279, IPR026092): Sine oculis-binding protein CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
18	CDK13	interactor	5	0.500	1.508	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Pkinase (PF00069, IPR000719): Protein kinase domain Macoilin (PF09726, IPR019130): Transmembrane protein THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
19	CHD3	oncoprotein	12	0.473	11.084	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) FAM176 (PF14851): FAM176 family
20	CHERP	interactor	22	0.442	33.764	CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. G-patch (PF01585, IPR000467, SM00443): G-patch domain HpaP (PF09483, IPR013390): Type III secretion protein (HpaP) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit TP2 (PF01254, IPR000678): Nuclear transition protein 2 Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain Surp (PF01805, IPR000061, SM00648): Surp module
21	COLGALT1	interactor	2	1.000	0	Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
22	COPS5	protein found in more fusions	45	0.330	156.665	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
23	CPSF6	interactor	18	0.510	19.794	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1
24	CSNK2A1	oncoprotein	34	0.301	186.824	Pkinase (PF00069, IPR000719): Protein kinase domain
25	CSNK2A2	interactor	19	0.310	54.286	Pkinase (PF00069, IPR000719): Protein kinase domain
26	CUL3	protein found in more fusions	66	0.277	548.951	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
27	CUL7	protein found in more fusions	63	0.277	430.494	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
28	CYFIP1	interactor	8	0.500	7.270	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
29	CYFIP2	interactor	10	0.400	15.277	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family zf-CW (PF07496, IPR011124): CW-type Zinc Finger
30	DAAM1	interactor	1	0	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain Phage_GPO (PF05929, IPR009228): Phage capsid scaffolding protein (GPO) serine peptidase
31	DDX18	interactor	18	0.523	14.407	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217)
32	DDX46	interactor	14	0.538	12.829	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) CdAMP_rec (PF06153, IPR010375): Cyclic-di-AMP receptor DDRGK (PF09756, IPR019153, SM01128): DDRGK domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FAM176 (PF14851): FAM176 family
33	DDX5	oncoprotein	38	0.509	94.060	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
34	DHX15	interactor	36	0.505	72.931	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
35	DHX8	protein found in more fusions	14	0.333	23.293	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
36	DHX9	oncoprotein	33	0.500	47.727	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
37	DIAPH1	interactor	5	0.700	0.257	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Drf_DAD (PF06345, IPR010465): DRF Autoregulatory Domain Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1 Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain Glucan_synthase (PF02364, IPR003440): 1,3-beta-glucan synthase component Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
38	EED	suppressor	40	0.347	141.365	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
39	EIF4A3	interactor	40	0.462	122.840	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
40	ERG	oncoprotein	16	0.408	11.680	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
41	EVL	oncoprotein	6	0.600	2.286	VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain WH1 (PF00568, IPR000697, SM00461): WH1 domain
42	EWSR1	oncoprotein	35	0.310	173.479	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
43	FMN1	interactor	1	0	0	FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain FAM184 (PF15665): Family with sequence similarity 184, A and B
44	FMNL1	protein found in more fusions	5	0.500	1.015	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain SlyX (PF04102, IPR007236): SlyX FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
45	FMNL2	interactor	2	1.000	0	Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
46	FMNL3	oncoprotein	2	1.000	0	Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain DUF572 (PF04502, IPR007590): Family of unknown function (DUF572) FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain STAS_2 (PF13466, IPR002645): STAS domain
47	FNBP4	oncoprotein	3	0.667	0.182	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pap_E4 (PF02711, IPR003861): E4 protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) WW (PF00397, IPR001202, SM00456): WW domain DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
48	FRA10AC1	interactor	6	0.667	1.475	SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region Fra10Ac1 (PF09725, IPR019129): Folate-sensitive fragile site protein Fra10Ac1 UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
49	GALNT2	interactor	1	0	0	Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2 Ricin_B_lectin (PF00652, IPR000772, SM00458): Ricin-type beta-trefoil lectin domain
50	GAPDH	oncoprotein	17	0.358	30.146	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
51	HIPK1	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
52	HNRNPF	interactor	30	0.529	34.221	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
53	HNRNPK	oncoprotein	40	0.521	110.645	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
54	HNRNPM	interactor	40	0.468	97.436	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
55	HNRNPR	interactor	37	0.550	61.272	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
56	HNRNPU	interactor	50	0.362	264.443	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
57	HNRNPUL1	protein found in more fusions	22	0.405	29.650	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
58	HSPB1	oncoprotein	19	0.595	8.473	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
59	HTT	protein found in more fusions	16	0.238	57.015	HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
60	IFI16	suppressor	22	0.281	69.587	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
61	IL1RAP	interactor	1	0	0	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain TIR (PF01582, IPR000157, SM00255): TIR domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
62	JMJD6	interactor	10	0.333	19.316	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
63	LARP7	interactor	11	0.309	11.314	Agouti (PF05039, IPR007733, SM00792): Agouti protein DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) La (PF05383, IPR006630, SM00715): La domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 (PF08777, IPR014886): RNA binding motif
64	LTBP3	oncoprotein	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain TB (PF00683, IPR017878): TB domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
65	LUC7L	protein found in more fusions	25	0.420	51.834	LUC7 (PF03194, IPR004882): LUC7 N_terminus Hid1 (PF12722): High-temperature-induced dauer-formation protein
66	MAP1LC3A	interactor	9	0.417	11.081	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
67	MECP2	interactor	3	0.667	0.400	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
68	MRPL1	interactor	3	0.667	0.500	CUB_2 (PF02408, IPR003366): CUB-like domain Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
69	MRPL38	interactor	6	0.467	5.276	PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein DUF3095 (PF11294, IPR021445): Protein of unknown function (DUF3095)
70	NCBP3	interactor	6	0.533	1.277	Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) TLP-20 (PF06088, IPR009092): Nucleopolyhedrovirus telokin-like protein-20 (TLP20) TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3 RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
71	NCKAP1L	interactor	4	0.833	0.286	Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein
72	NCSTN	interactor	15	0.419	17.530	Nicastrin (PF05450, IPR008710): Nicastrin Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
73	NEIL3	interactor	3	0.667	0.167	Fapy_DNA_glyco (PF01149, IPR012319, SM00898): Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH (PF06831, IPR015886): Formamidopyrimidine-DNA glycosylase H2TH domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-GRF (PF06839, IPR010666): GRF zinc finger zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
74	NKAP	interactor	13	0.273	24.255	SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist Pheromone (PF08015, IPR012597): Fungal mating-type pheromone SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein NKAP (PF15692): NF-kappa-B-activating protein
75	NONO	oncoprotein	27	0.474	34.377	GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF NOPS (PF08075, IPR012975): NOPS (NUC059) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAS_7 (PF12860): PAS fold SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
76	NPM3	interactor	5	0.600	0.636	Nucleoplasmin (PF03066): Nucleoplasmin
77	NR2C2	suppressor	4	0.667	1.000	Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
78	NTRK1	oncoprotein	84	0.183	1445.930	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
79	OBSL1	protein found in more fusions	60	0.282	322.376	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
80	PAXIP1	interactor	17	0.279	29.666	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
81	PCBP2	protein found in more fusions	13	0.379	8.802	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
82	PDCD7	interactor	2	1.000	0	PDCD7 (PF16021, IPR031974): Programmed cell death protein 7
83	PDZD2	interactor	1	0	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
84	PECAM1	oncoprotein	3	1.000	0	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
85	PES1	interactor	15	0.582	6.063	Pescadillo_N (PF06732, IPR010613): Pescadillo N-terminus RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 DUF3347 (PF11827, IPR021782): Protein of unknown function (DUF3347) U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
86	PFKL	protein found in more fusions	8	0.476	3.993	PFK (PF00365, IPR000023): Phosphofructokinase
87	PIAS1	suppressor	12	0.291	22.488	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
88	PIAS3	oncoprotein	5	0.600	3.286	SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain
89	PIAS4	interactor	11	0.473	16.860	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain
90	PNN	suppressor	22	0.545	24.339	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
91	PPIG	interactor	10	0.533	7.610	Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Apis_Csd (PF11671, IPR021007): Complementary sex determiner protein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
92	PPP1R35	interactor	1	0	0	PPP1R35_C (PF15503, IPR029135): Protein phosphatase 1 regulatory subunit 35 C-terminus
93	PRKAR1A	suppressor	6	0.400	2.684	RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
94	PRSS12	interactor	1	0	0	Kringle (PF00051, IPR000001): Kringle domain SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain Trypsin (PF00089, IPR001254, SM00020): Trypsin
95	PSG5	interactor	1	0	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
96	PTPRF	interactor	3	0.667	0.037	Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST) C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
97	PUF60	protein found in more fusions	30	0.463	61.046	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Titin_Z (PF09042, IPR015129): Titin Z TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
98	RBM25	interactor	33	0.282	175.796	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 PWI (PF01480, IPR002483, SM00311): PWI domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 DUF3441 (PF11923, IPR021846): Domain of unknown function (DUF3441) U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4778 (PF16008, IPR031958): Domain of unknown function (DUF4778)
99	RBM39	oncoprotein	41	0.345	181.749	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
100	RBMX2	interactor	4	0.667	2.000	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
101	RCC2	oncoprotein	8	0.429	2.398	RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
102	RLF	oncoprotein	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
103	RNPS1	interactor	37	0.374	168.497	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) Macoilin (PF09726, IPR019130): Transmembrane protein
104	RNU1-4	interactor	2	1.000	0	NA
105	RNU2-1	interactor	2	1.000	0	NA
106	RPA1	suppressor	39	0.395	87.231	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
107	RPA2	oncoprotein	37	0.345	98.056	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
108	RPA3	interactor	36	0.370	69.755	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
109	RPL37A	interactor	13	0.564	6.324	Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
110	RPL4	interactor	16	0.517	22.514	Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
111	RPLP0	interactor	20	0.489	18.601	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
112	RPS9	interactor	16	0.608	7.348	Ribosomal_S4 (PF00163, IPR001912): Ribosomal protein S4/S9 N-terminal domain S4 (PF01479, IPR002942, SM00363): S4 domain
113	RRS1	interactor	19	0.544	14.739	GRP (PF07172, IPR010800): Glycine rich protein family RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 RRS1 (PF04939, IPR007023): Ribosome biogenesis regulatory protein (RRS1)
114	SAP18	interactor	17	0.551	14.208	SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
115	SART1	interactor	33	0.480	67.377	SART-1 (PF03343, IPR005011): SART-1 family Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
116	SDCBP	interactor	7	0.381	7.043	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
117	SDCBP2	protein found in more fusions	4	0.667	0.400	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
118	SDK1	interactor	1	0	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
119	SERPINB9	interactor	4	0.500	1.682	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
120	SF1	protein found in more fusions	17	0.625	8.050	UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
121	SF3A1	interactor	39	0.522	67.399	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
122	SF3A2	interactor	36	0.492	53.317	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
123	SF3A3	interactor	24	0.514	41.664	DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449) SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain Telomere_Sde2_2 (PF13297): Telomere stability C-terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
124	SF3B1	oncoprotein	40	0.501	75.589	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1 UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
125	SF3B2	interactor	31	0.391	109.120	DUF382 (PF04037, IPR007180): Domain of unknown function (DUF382) PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region PSP (PF04046, IPR006568, SM00581): PSP SAP (PF02037, IPR003034, SM00513): SAP domain Usp (PF00582, IPR006016): Universal stress protein family Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 Vma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
126	SF3B3	interactor	42	0.502	79.687	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
127	SF3B4	interactor	24	0.409	41.473	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
128	SFPQ	oncoprotein	32	0.501	36.467	GRP (PF07172, IPR010800): Glycine rich protein family Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein NOPS (PF08075, IPR012975): NOPS (NUC059) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
129	SIRT7	interactor	45	0.236	256.141	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
130	SLC30A4	interactor	2	1.000	0	Cation_efflux (PF01545, IPR002524): Cation efflux family
131	SMAD4	suppressor	13	0.318	26.115	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
132	SNIP1	interactor	17	0.368	40.546	FHA (PF00498, IPR000253, SM00240): FHA domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 FAM176 (PF14851): FAM176 family
133	SNRNP70	interactor	27	0.459	54.556	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
134	SNU13	interactor	27	0.366	50.175	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
135	SNW1	protein found in more fusions	57	0.321	427.461	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
136	SON	interactor	20	0.579	13.608	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region G-patch (PF01585, IPR000467, SM00443): G-patch domain tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1 GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer RSRP (PF17069): Arginine/Serine-Rich protein 1
137	SRRM1	interactor	35	0.449	88.056	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
138	SRRM2	interactor	50	0.447	153.058	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
139	STAU1	protein found in more fusions	33	0.377	90.620	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
140	STIM2	interactor	1	0	0	DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 MAGSP (PF03082, IPR004315): Male accessory gland secretory protein SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446) SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
141	SYNCRIP	interactor	32	0.530	58.145	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
142	TCEAL9	interactor	1	0	0	BEX (PF04538, IPR021156): Brain expressed X-linked like family
143	TCERG1	interactor	39	0.262	343.642	FF (PF01846, IPR002713, SM00441): FF domain WW (PF00397, IPR001202, SM00456): WW domain Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807) DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO FAM150 (PF15129, IPR029364): FAM150 family
144	TERF2	interactor	20	0.240	73.457	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
145	TERF2IP	protein found in more fusions	5	0.833	0.200	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain Histone_HNS (PF00816, IPR001801): H-NS histone family Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
146	TRA2A	interactor	30	0.411	83.390	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
147	TRMT112	interactor	9	0.528	2.948	Trm112p (PF03966, IPR005651): Trm112p-like protein
148	TSNAX	interactor	6	0.400	4.201	Translin (PF01997, IPR002848): Translin family
149	U2AF1	oncoprotein	38	0.394	169.378	DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509) KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
150	U2AF2	protein found in more fusions	56	0.413	232.861	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
151	U2SURP	interactor	18	0.431	13.171	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB) Surp (PF01805, IPR000061, SM00648): Surp module CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3 FAM176 (PF14851): FAM176 family TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2 DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
152	UBE2I	interactor	28	0.214	179.221	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
153	UBE2K	interactor	5	0.700	0.794	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
154	UBQLN1	protein found in more fusions	9	0.536	7.069	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X
155	UBQLN2	protein found in more fusions	8	0.524	4.478	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family SUZ (PF12752, IPR024771): SUZ domain Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
156	UBQLN4	interactor	8	0.429	7.533	CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Arm_2 (PF04826, IPR006911): Armadillo-like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
157	UBR4	interactor	3	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Pheromone (PF08015, IPR012597): Fungal mating-type pheromone RecR (PF02132, IPR023628): RecR protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) DZR (PF12773, IPR025874): Double zinc ribbon E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4 FAM176 (PF14851): FAM176 family
158	UTP14A	interactor	21	0.452	31.723	Utp14 (PF04615, IPR006709): Utp14 protein
159	VASP	interactor	10	0.333	15.000	ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2 CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain WH1 (PF00568, IPR000697, SM00461): WH1 domain
160	VCL	oncoprotein	7	0.533	3.335	Vinculin (PF01044, IPR006077): Vinculin family
161	VPS16	interactor	3	0.667	0.500	Vps16_C (PF04840, IPR006925): Vps16, C-terminal region Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
162	VTN	interactor	18	0.608	8.397	Hemopexin (PF00045, IPR018487, SM00120): Hemopexin Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
163	WAS	oncoprotein	7	0.381	9.368	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain WH1 (PF00568, IPR000697, SM00461): WH1 domain WH2 (PF02205, IPR003124, SM00246): WH2 motif PRIMA1 (PF16101): Proline-rich membrane anchor 1
164	WASF2	oncoprotein	7	0.762	1.736	RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase WH2 (PF02205, IPR003124, SM00246): WH2 motif WASH_WAHD (PF11945, IPR021854): WAHD domain of WASH complex
165	WASL	interactor	7	0.381	9.115	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain WH1 (PF00568, IPR000697, SM00461): WH1 domain WH2 (PF02205, IPR003124, SM00246): WH2 motif RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
166	WIPF1	interactor	3	0.667	1.000	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GRP (PF07172, IPR010800): Glycine rich protein family WH2 (PF02205, IPR003124, SM00246): WH2 motif
167	WWOX	suppressor	34	0.237	163.972	adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain
168	XRCC6	oncoprotein	28	0.319	113.962	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain
169	YBX1	oncoprotein	22	0.541	39.416	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
170	YEATS4	interactor	1	0	0	YEATS (PF03366, IPR005033): YEATS family SOGA (PF11365, IPR027881): Protein SOGA
171	YLPM1	interactor	6	0.533	0.626	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Com_YlbF (PF06133, IPR010368): Control of competence regulator ComK, YlbF/YmcA TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit AAA_33 (PF13671): AAA domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
172	YWHAG	protein found in more fusions	17	0.567	17.062	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
173	ZBTB8OS	interactor	1	0	0	Archease (PF01951, IPR023572): Archease protein family (MTH1598/TM1083)
174	ZCCHC10	interactor	12	0.318	24.542	Macoilin (PF09726, IPR019130): Transmembrane protein SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein zf-CCHC_3 (PF13917): Zinc knuckle
175	ZCCHC8	interactor	10	0.533	2.352	Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein PSP (PF04046, IPR006568, SM00581): PSP zf-CCHC (PF00098, IPR001878): Zinc knuckle DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
176	ZFHX3	suppressor	2	1.000	0	AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X DUF629 (PF04780, IPR006865): Protein of unknown function (DUF629) GRP (PF07172, IPR010800): Glycine rich protein family Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) YL1 (PF05764, IPR008895): YL1 nuclear protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-HIT (PF04438, IPR007529): HIT zinc finger Bud13 (PF09736, IPR018609): Pre-mRNA-splicing factor of RES complex Homeobox (PF00046, IPR001356, SM00389): Homeobox domain KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term Spt20 (PF12090, IPR021950): Spt20 family DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-met (PF12874): Zinc-finger of C2H2 type MerR_1 (PF13411, IPR000551): MerR HTH family regulatory protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain AAA_23 (PF13476): AAA domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger RMP (PF14996, IPR029239): Retinal Maintenance WRNPLPNID (PF15017): Putative WW-binding domain and destruction box TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2 zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
177	ZHX1	interactor	8	0.571	5.709	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Homeobox (PF00046, IPR001356, SM00389): Homeobox domain Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez zf-C2H2_4 (PF13894): C2H2-type zinc finger TerB_C (PF15615, IPR028932): TerB-C domain
178	ZNF451	protein found in more fusions	6	0.700	1.952	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type EPL1 (PF10513, IPR019542): Enhancer of polycomb-like zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-met (PF12874): Zinc-finger of C2H2 type zf-C2H2_4 (PF13894): C2H2-type zinc finger Cys_rich_KTR (PF14205, IPR025957): Cysteine-rich KTR FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain

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