Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRKDC (from a repository: Sat Dec 3 06:11:46 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 234 The number (and %) of the onco-proteins 81 (34.62 %) The number (and %) of the tumor suppressors 36 (15.38 %) Total number of binary PPIs (saturation %) 2618 (9.60 %) The number (and %) of affected PPIs 234 (8.94 %) The number of possible different fusions 53 PPI diameter 2 PPI radius 1 The average degree of PPI 21.359 Assortativity coefficient -0.2179 The network average Clustering coefficient 0.452 The number (and %) of a zero Clustering coefficients 5 (2.14 %) The number (and %) of a zero Betweenness Centrality 18 (7.69 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PRKDC	All fusions : W28344; BE548041;
Proteins found in more fusions	GRK5 (see 4 fusions); CTPS2 (see 1 fusions); U2AF2 (see 2 fusions); DCAF1 (see 1 fusions); HSF1 (see 3 fusions); PINK1 (see 3 fusions); PRKDC (see 3 fusions); PRDX1 (see 1 fusions); HDAC5 (see 1 fusions); IKBKB (see 2 fusions); EP300 (see 1 fusions); PCNA (see 1 fusions); DDX5 (see 1 fusions); RPA1 (see 1 fusions); SNW1 (see 1 fusions); POU2F1 (see 1 fusions); HSP90AA1 (see 2 fusions); HSP90AB1 (see 1 fusions); RBBP8 (see 1 fusions); USF1 (see 3 fusions); YY1 (see 2 fusions); PRPF8 (see 3 fusions); BAG3 (see 4 fusions); KAT8 (see 1 fusions); CSNK2A1 (see 1 fusions); SHC1 (see 1 fusions); STAU1 (see 2 fusions); GSK3B (see 1 fusions); CUL7 (see 2 fusions); CSNK2A1/ELAVL1 (see 1 fusions); CUL3 (see 1 fusions); MAPK9 (see 3 fusions); MYC (see 1 fusions); SKI (see 1 fusions); COPS5 (see 1 fusions); PARP1 (see 1 fusions); LRRK2 (see 1 fusions); THRA (see 3 fusions); TP53 (see 3 fusions); AP2M1 (see 3 fusions); ILK (see 1 fusions); LMNA (see 3 fusions); CRY2 (see 3 fusions); LYN (see 2 fusions); NR3C1 (see 8 fusions); NCOA6 (see 1 fusions); SP1 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); KAT5 (see 3 fusions); HNRNPC (see 1 fusions); NTRK1/TPR (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PRKDC	parental protein	234	0.084	28337.733	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
2	ABL1	oncoprotein	21	0.400	38.135	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	ADRB2	interactor	4	0.667	0.154	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4	AICDA	interactor	6	0.600	0.560	APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
5	AIRE	interactor	14	0.359	8.649	PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
6	AKT1	oncoprotein	30	0.271	149.912	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
7	AKT2	oncoprotein	10	0.400	13.323	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
8	ALOX15	suppressor	1	0	0	Lipoxygenase (PF00305, IPR013819): Lipoxygenase PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
9	ANAPC2	interactor	8	0.536	4.042	ANAPC2 (PF08672, IPR014786, SM01013): Anaphase promoting complex (APC) subunit 2 Cullin (PF00888, IPR001373, SM00182): Cullin family
10	AP1B1	interactor	15	0.476	12.922	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
11	AP2M1	protein found in more fusions	17	0.325	34.802	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
12	AR	oncoprotein	27	0.345	66.842	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
13	ARHGEF6	oncoprotein	2	0	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_9 (PF14604, IPR001452): Variant SH3 domain betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7 RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
14	ASB5	interactor	2	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
15	ATG101	interactor	3	0.667	0.286	ATG101 (PF07855, IPR012445): Autophagy-related protein 101
16	ATG4C	interactor	1	0	0	Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
17	ATM	suppressor	41	0.241	330.881	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
18	ATRIP	interactor	8	0.821	0.619	Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
19	ATRX	oncoprotein	14	0.495	15.567	DDHD (PF02862, IPR004177, SM01127): DDHD domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Zip (PF02535, IPR003689): ZIP Zinc transporter DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992) DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex FAM176 (PF14851): FAM176 family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
20	AUP1	interactor	7	0.381	4.474	CUE (PF02845, IPR003892, SM00546): CUE domain
21	BAG3	oncoprotein	19	0.222	78.783	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
22	BECN1	suppressor	7	0.533	2.938	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
23	BIRC5	interactor	10	0.556	4.514	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
24	BMI1	oncoprotein	29	0.333	66.753	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
25	BRCA1	suppressor	58	0.249	528.114	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
26	C14orf166	interactor	23	0.494	36.727	RLL (PF10036, IPR019265): Putative carnitine deficiency-associated protein
27	C1D	interactor	3	0.667	0.250	Sas10_Utp3 (PF04000, IPR007146): Sas10/Utp3/C1D family
28	CAMKK2	oncoprotein	3	0.667	0.143	Pkinase (PF00069, IPR000719): Protein kinase domain
29	CASP3	interactor	14	0.308	32.155	Peptidase_C14 (PF00656, IPR011600): Caspase domain
30	CCDC8	interactor	39	0.317	107.851	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
31	CCNB1	oncoprotein	14	0.451	15.852	Adeno_E1A (PF02703, IPR003853): Early E1A protein Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
32	CDC5L	interactor	65	0.282	503.388	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
33	CDK2	suppressor	50	0.304	286.803	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
34	CENPA	interactor	16	0.419	15.888	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
35	CFTR	suppressor	9	0.357	6.513	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
36	CHAF1A	interactor	16	0.438	21.459	CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA
37	CHD1L	interactor	13	0.615	8.164	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
38	CHEK1	suppressor	14	0.615	4.577	Pkinase (PF00069, IPR000719): Protein kinase domain
39	CHEK2	suppressor	8	0.810	0.672	FHA (PF00498, IPR000253, SM00240): FHA domain Pkinase (PF00069, IPR000719): Protein kinase domain
40	CHUK	suppressor	19	0.523	19.486	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
41	CIB1	interactor	1	0	0	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
42	CLK1	interactor	8	0.476	6.237	PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region Pkinase (PF00069, IPR000719): Protein kinase domain
43	CLN3	interactor	6	0.333	3.552	CLN3 (PF02487, IPR003492): CLN3 protein
44	COPS5	protein found in more fusions	49	0.298	277.374	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
45	CRY1	interactor	11	0.311	6.326	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
46	CRY2	protein found in more fusions	14	0.359	13.740	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
47	CSNK2A1	oncoprotein	39	0.304	192.838	Pkinase (PF00069, IPR000719): Protein kinase domain
48	CTDP1	interactor	4	0.500	1.582	Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme FCP1_C (PF09309, IPR015388): FCP1, C-terminal NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A PTCB-BRCT (PF12738, IPR001357): twin BRCT domain HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
49	CTPS2	protein found in more fusions	8	0.524	7.352	CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
50	CUL3	protein found in more fusions	58	0.262	410.216	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
51	CUL5	suppressor	33	0.347	114.837	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
52	CUL7	protein found in more fusions	48	0.354	154.222	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
53	CWC27	interactor	5	0.500	2.900	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
54	DCAF1	protein found in more fusions	16	0.286	33.794	DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) LisH (PF08513, IPR013720, SM00667): LisH ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
55	DCLRE1B	interactor	5	0.800	0.750	DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
56	DCLRE1C	interactor	10	0.489	15.837	DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase DUF3290 (PF11694, IPR021707): Protein of unknown function (DUF3290) Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
57	DDA1	interactor	5	0.600	0.742	DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
58	DDX5	oncoprotein	48	0.247	248.900	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
59	DHX38	interactor	8	0.607	3.906	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
60	DHX9	oncoprotein	57	0.362	269.954	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
61	DNAJC7	interactor	17	0.419	27.903	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_17 (PF13431): Tetratricopeptide repeat
62	E4F1	interactor	4	0.833	0.500	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
63	EED	suppressor	45	0.245	219.723	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
64	EFTUD2	interactor	39	0.312	133.227	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
65	EGFR	oncoprotein	43	0.238	320.511	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
66	EHD1	interactor	8	0.524	5.068	Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1) Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
67	EIF2S2	interactor	11	0.527	3.418	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 Cytochrom_c3_2 (PF14537): Cytochrome c3
68	EIF4EBP1	oncoprotein	7	0.429	5.112	eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
69	ELAVL1	oncoprotein	55	0.202	553.305	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
70	EMD	interactor	31	0.248	156.310	LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
71	EP300	oncoprotein	50	0.257	361.290	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
72	ERG	oncoprotein	17	0.478	15.110	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
73	ESR1	suppressor	54	0.293	339.606	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
74	FAF2	interactor	15	0.330	31.244	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain
75	FBXO6	interactor	30	0.290	102.844	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
76	FLII	oncoprotein	15	0.533	11.341	Gelsolin (PF00626, IPR007123): Gelsolin repeat SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
77	FN1	oncoprotein	41	0.306	123.211	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
78	FOXRED2	interactor	3	1.000	0	Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
79	FZR1	suppressor	9	0.389	10.251	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
80	GBAS	interactor	4	0.833	0.143	NIPSNAP (PF07978, IPR012577): NIPSNAP
81	GRK5	protein found in more fusions	13	0.318	18.377	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
82	GSK3A	interactor	5	0.800	0.265	Pkinase (PF00069, IPR000719): Protein kinase domain
83	GSK3B	suppressor	18	0.360	46.026	Pkinase (PF00069, IPR000719): Protein kinase domain
84	GTF2I	interactor	25	0.290	92.373	GTF2I (PF02946, IPR004212): GTF2I-like repeat
85	GZMB	interactor	5	0.600	1.280	Trypsin (PF00089, IPR001254, SM00020): Trypsin
86	H2AFX	suppressor	37	0.323	152.614	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
87	H3F3A	oncoprotein	14	0.505	13.869	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
88	HDAC11	interactor	7	0.381	6.261	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
89	HDAC3	suppressor	26	0.347	68.729	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
90	HDAC5	protein found in more fusions	34	0.350	76.098	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
91	HDGF	interactor	24	0.344	49.631	PWWP (PF00855, IPR000313, SM00293): PWWP domain
92	HDLBP	oncoprotein	17	0.456	18.915	BMC (PF00936, IPR000249, SM00877): BMC domain KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain KH_5 (PF13184, IPR025249): NusA-like KH domain SLS (PF14611, IPR032741): Mitochondrial inner-membrane-bound regulator DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
93	HIST1H1A	interactor	12	0.364	13.689	Mucin (PF01456, IPR000458): Mucin-like glycoprotein Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
94	HIST1H1C	oncoprotein	18	0.373	26.489	Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
95	HIST1H3A	interactor	28	0.208	156.174	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
96	HIST1H3E	interactor	19	0.363	26.768	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
97	HNRNPA1	interactor	63	0.344	447.025	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
98	HNRNPC	protein found in more fusions	39	0.434	69.795	APG6 (PF04111, IPR007243): Autophagy protein Apg6 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
99	HOXB7	interactor	4	1.000	0	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
100	HSF1	protein found in more fusions	12	0.382	14.305	DUF247 (PF03140, IPR004158): Plant protein of unknown function Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
101	HSP90AA1	oncoprotein	66	0.202	809.052	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
102	HSP90AB1	oncoprotein	52	0.216	430.712	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
103	HSPA5	oncoprotein	52	0.307	327.488	HSP70 (PF00012, IPR013126): Hsp70 protein
104	HSPA8	oncoprotein	54	0.245	387.716	HSP70 (PF00012, IPR013126): Hsp70 protein
105	IKBKAP	interactor	15	0.374	21.272	IKI3 (PF04762, IPR006849): IKI3 family Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
106	IKBKB	protein found in more fusions	13	0.545	6.597	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
107	ILF2	interactor	43	0.434	96.545	DZF (PF07528, IPR006561, SM00572): DZF domain
108	ILF3	oncoprotein	46	0.325	208.651	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
109	ILK	suppressor	19	0.392	30.171	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
110	IQCB1	interactor	8	0.393	2.181	DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765) IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
111	ITGA4	interactor	31	0.359	70.038	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
112	JUN	oncoprotein	27	0.378	65.146	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
113	KAT2A	interactor	12	0.600	4.123	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
114	KAT5	suppressor	27	0.375	57.901	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
115	KAT8	protein found in more fusions	9	0.500	6.949	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
116	LGR4	interactor	10	0.389	6.150	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
117	LIG4	interactor	7	0.714	1.580	APG17 (PF04108, IPR007240): Autophagy protein Apg17 BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
118	LMNA	protein found in more fusions	40	0.341	154.977	Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
119	LRRFIP1	oncoprotein	10	0.667	5.544	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3 LRRFIP (PF09738, IPR019139): LRRFIP family RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region Coilin_N (PF15862, IPR031722): Coilin N-terminus
120	LRRK2	oncoprotein	13	0.318	24.989	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
121	LYN	oncoprotein	11	0.600	2.996	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
122	MAPK8	oncoprotein	16	0.400	27.389	DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain
123	MAPK9	suppressor	9	0.500	7.860	Pkinase (PF00069, IPR000719): Protein kinase domain Kinase-like (PF14531, IPR027916): Kinase-like
124	MBP	interactor	3	0.667	0.400	Myelin_MBP (PF01669, IPR000548): Myelin basic protein
125	MCM2	oncoprotein	56	0.294	383.409	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
126	MDC1	suppressor	36	0.313	172.710	FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
127	METTL1	interactor	6	0.533	4.100	Methyltransf_4 (PF02390, IPR003358): Putative methyltransferase
128	MEX3C	interactor	6	0.533	0.857	KH_1 (PF00013, IPR004088, SM00322): KH domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
129	MGMT	interactor	13	0.577	5.355	DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
130	MKNK1	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
131	MLH1	suppressor	14	0.505	15.722	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
132	MRE11A	oncoprotein	41	0.315	216.929	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
133	MSH6	oncoprotein	31	0.325	122.124	MutS_I (PF01624, IPR007695): MutS domain I MutS_II (PF05188, IPR007860): MutS domain II PWWP (PF00855, IPR000313, SM00293): PWWP domain MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III UPF0524 (PF15823, IPR029670): UPF0524 of C3orf70
134	MSL3	interactor	3	1.000	0	GET2 (PF08690, IPR028143): GET complex subunit GET2 MRG (PF05712, IPR026541): MRG Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
135	MYC	oncoprotein	47	0.276	296.763	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
136	NBN	suppressor	29	0.352	97.394	FHA (PF00498, IPR000253, SM00240): FHA domain Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1 NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
137	NCF1	interactor	6	0.500	4.500	p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain PX (PF00787, IPR001683, SM00312): PX domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
138	NCF2	interactor	3	1.000	0	PB1 (PF00564, IPR000270, SM00666): PB1 domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain TPR_16 (PF13432): Tetratricopeptide repeat
139	NCF4	interactor	4	0.667	2.000	PX (PF00787, IPR001683, SM00312): PX domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
140	NCOA6	oncoprotein	16	0.495	18.916	DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Presenilin (PF01080, IPR001108): Presenilin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region NST1 (PF13945, IPR025279): Salt tolerance down-regulator
141	NOS2	interactor	13	0.424	8.012	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
142	NOTCH1	suppressor	18	0.279	35.238	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
143	NR1H4	interactor	7	0.810	0.939	LRV_FeS (PF05484, IPR008665): LRV protein FeS4 cluster zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
144	NR3C1	protein found in more fusions	15	0.451	12.892	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
145	NTRK1	oncoprotein	87	0.184	1423.850	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
146	NUCB1	interactor	6	0.600	2.630	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967) DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552) EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
147	NUP107	interactor	14	0.538	9.910	Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107
148	NUP35	interactor	8	0.679	1.821	Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
149	NUP85	interactor	12	0.439	14.955	Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
150	OBSL1	interactor	48	0.314	196.393	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
151	PAN2	interactor	24	0.315	50.502	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
152	PARP1	suppressor	60	0.214	552.284	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
153	PCNA	oncoprotein	45	0.254	285.757	PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
154	PDX1	suppressor	3	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Homeobox (PF00046, IPR001356, SM00389): Homeobox domain TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
155	PGR	suppressor	14	0.679	5.442	Prog_receptor (PF02161, IPR000128): Progesterone receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
156	PHGDH	interactor	23	0.356	40.353	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
157	PHKG2	interactor	3	1.000	0	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
158	PIDD1	interactor	5	0.400	2.344	Death (PF00531, IPR000488, SM00005): Death domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain Peptidase_S68 (PF10461, IPR019502): Peptidase S68 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
159	PINK1	protein found in more fusions	5	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
160	PMS2	oncoprotein	9	0.528	3.813	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain MORN_2 (PF07661, IPR011652): MORN repeat variant MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
161	PNKP	interactor	13	0.513	12.852	PNK3P (PF08645, IPR013954): Polynucleotide kinase 3 phosphatase AAA_33 (PF13671): AAA domain
162	POT1	interactor	9	0.643	3.896	POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
163	POU2F1	protein found in more fusions	14	0.615	6.845	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
164	POU5F1	oncoprotein	18	0.279	45.414	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
165	PPP2CA	suppressor	28	0.235	110.962	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
166	PPP6C	interactor	14	0.330	32.005	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
167	PPP6R1	interactor	11	0.473	15.954	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
168	PPP6R2	interactor	7	0.619	4.600	SAMP (PF05924, IPR009224): SAMP Motif SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
169	PPP6R3	interactor	15	0.343	36.322	SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
170	PRDX1	oncoprotein	32	0.258	127.441	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
171	PRKAB2	interactor	3	1.000	0	AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
172	PRPF8	oncoprotein	36	0.336	98.443	PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain PROCN (PF08083, IPR012592): PROCN (NUC071) domain PROCT (PF08084, IPR012984): PROCT (NUC072) domain RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8 U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8 U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8 JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
173	PTER	interactor	3	1.000	0	PTE (PF02126, IPR001559): Phosphotriesterase family
174	RAD17	interactor	4	0.667	0.686	Mvb12 (PF09452, IPR019014): ESCRT-I subunit Mvb12 Rad17 (PF03215): Rad17 cell cycle checkpoint protein
175	RAD21	oncoprotein	23	0.372	36.209	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
176	RANBP2	oncoprotein	29	0.349	97.214	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
177	RASSF1	suppressor	5	0.667	1.000	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
178	RBBP8	suppressor	8	0.619	2.970	ZapB (PF06005, IPR009252): Cell division protein ZapB Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
179	RBM25	interactor	16	0.300	17.898	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 PWI (PF01480, IPR002483, SM00311): PWI domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 DUF3441 (PF11923, IPR021846): Domain of unknown function (DUF3441) U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4778 (PF16008, IPR031958): Domain of unknown function (DUF4778)
180	RECQL5	oncoprotein	9	0.556	3.927	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase RecQ5 (PF06959, IPR010716): RecQ helicase protein-like 5 (RecQ5) SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding TAtT (PF16811, IPR031823): TRAP transporter T-component
181	RELA	oncoprotein	34	0.318	143.428	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
182	RFC2	interactor	21	0.367	48.976	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain AAA_16 (PF13191): AAA ATPase domain AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
183	RNF144A	suppressor	2	0	0	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
184	RPA1	suppressor	59	0.301	413.530	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
185	RPA2	oncoprotein	44	0.331	161.395	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
186	RPA3	interactor	40	0.335	111.287	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
187	RPS11	interactor	17	0.397	12.675	Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17 Ribosomal_S17_N (PF16205, IPR032440): Ribosomal_S17 N-terminal
188	RTCB	interactor	24	0.460	41.736	RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
189	RUVBL1	oncoprotein	41	0.227	248.744	TIP49 (PF06068, IPR010339): TIP49 C-terminus
190	RYK	oncoprotein	6	0.667	3.143	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase WIF (PF02019, IPR003306, SM00469): WIF domain
191	SAP25	interactor	2	1.000	0	SAP25 (PF15476, IPR029163): Histone deacetylase complex subunit SAP25
192	SCARNA22	interactor	16	0.475	8.302	NA
193	SF3B6	interactor	18	0.536	20.032	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
194	SHC1	oncoprotein	18	0.500	16.605	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
195	SIRT6	suppressor	13	0.295	10.734	SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
196	SIRT7	interactor	34	0.275	134.701	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
197	SKI	oncoprotein	16	0.448	14.782	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
198	SMARCA5	interactor	30	0.352	62.117	HAND (PF09110, IPR015194): HAND SLIDE (PF09111, IPR015195): SLIDE SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DBINO (PF13892, IPR020838): DNA-binding domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
199	SMARCAD1	interactor	19	0.485	19.145	CUE (PF02845, IPR003892, SM00546): CUE domain Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
200	SNRPA	interactor	13	0.530	2.539	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
201	SNW1	protein found in more fusions	55	0.275	404.241	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
202	SP1	protein found in more fusions	22	0.505	35.352	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
203	SRF	interactor	10	0.528	4.170	SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
204	SRP14	interactor	12	0.394	10.455	SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
205	SRP54	interactor	8	0.571	3.838	5_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit SRP54 (PF00448, IPR000897, SM00962): SRP54-type protein, GTPase domain SRP54_N (PF02881, IPR013822, SM00963): SRP54-type protein, helical bundle domain SRP_SPB (PF02978, IPR004125): Signal peptide binding domain YlbD_coat (PF14071, IPR025953): Putative coat protein
206	SRSF10	interactor	12	0.515	8.445	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
207	STAU1	protein found in more fusions	31	0.409	76.759	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
208	SUMO2	interactor	19	0.373	25.469	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
209	TELO2	interactor	9	0.472	11.116	Telomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein HEAT_2 (PF13646): HEAT repeats
210	TERF1	interactor	20	0.339	51.445	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
211	THOC6	interactor	10	0.578	5.790	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
212	THRA	suppressor	13	0.485	13.344	C1_2 (PF03107, IPR004146): C1 domain zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
213	THRB	suppressor	10	0.556	6.335	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
214	THYN1	interactor	2	1.000	0	EVE (PF01878, IPR002740): EVE domain
215	TINF2	interactor	12	0.436	15.994	TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
216	TP53	suppressor	71	0.222	852.877	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
217	TPR	oncoprotein	24	0.373	58.643	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus ZapB (PF06005, IPR009252): Cell division protein ZapB Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 XhlA (PF10779, IPR019715): Haemolysin XhlA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3373 (PF11853, IPR021803): Protein of unknown function (DUF3373) DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
218	TRA2B	interactor	16	0.525	18.648	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
219	TTI1	interactor	9	0.528	6.719	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat VHS (PF00790, IPR002014, SM00288): VHS domain CLASP_N (PF12348, IPR024395): CLASP N terminal
220	TTI2	interactor	7	0.619	2.132	Tti2 (PF10521, IPR018870): Tti2 family
221	U2AF2	protein found in more fusions	43	0.413	128.675	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
222	UBAC2	interactor	4	0.667	1.333	Rhomboid (PF01694, IPR022764): Rhomboid family UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
223	UBE2I	interactor	38	0.272	203.640	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
224	UBXN6	interactor	6	0.533	3.800	PUB (PF09409, IPR018997): PUB domain UBX (PF00789, IPR001012, SM00166): UBX domain
225	USF1	oncoprotein	10	0.472	5.270	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
226	VCAM1	interactor	25	0.373	28.869	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
227	WRN	oncoprotein	22	0.519	31.937	DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease DEAD (PF00270, IPR011545): DEAD/DEAH box helicase HRDC (PF00570, IPR002121, SM00341): HRDC domain Laminin_II (PF06009, IPR010307): Laminin Domain II RQC (PF09382, IPR018982, SM00956): RQC domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain HTH_40 (PF14493, IPR029491): Helix-turn-helix domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
228	XPA	oncoprotein	5	0.700	0.372	XPA_C (PF05181, IPR022656): XPA protein C-terminus XPA_N (PF01286, IPR022652): XPA protein N-terminal MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1 zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
229	XRCC4	interactor	12	0.400	17.376	XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
230	XRCC5	suppressor	76	0.189	991.591	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
231	XRCC6	oncoprotein	80	0.204	1095.534	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain
232	YBX1	oncoprotein	31	0.312	88.234	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
233	YWHAQ	interactor	38	0.279	176.330	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
234	YY1	protein found in more fusions	20	0.439	22.630	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail

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