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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins3 (27.27 %)
The number (and %) of the tumor suppressors3 (27.27 %)
Total number of binary PPIs (saturation %)21 (38.18 %)
The number (and %) of affected PPIs11 (52.38 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.909
Assortativity coefficient-0.3143
The network average Clustering coefficient0.415
The number (and %) of a zero Clustering coefficients5 (45.45 %)
The number (and %) of a zero Betweenness Centrality8 (72.73 %)


List of the fusions

PPI for parental proteins: PRKCH All fusions
Proteins found in more fusions HSP90AA1 (see 2 fusions); VHL (see 1 fusions); PRKCH (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PRKCHparental protein110.13373.667C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
2 AKAP13oncoprotein100APG6 (PF04111, IPR007243): Autophagy protein Apg6
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
RII_binding_1 (PF10522, IPR018459): RII binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
3 BANPsuppressor200DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
4 CDK2suppressor50.8330.667Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
5 GSK3Ainteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
6 HSP90AA1oncoprotein60.6003.667HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
7 MGMTinteractor31.0000DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
8 NFE2L2oncoprotein100bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
9 PPP1R14Ainteractor100PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
10 VHLsuppressor41.0000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
11 ZBTB8OSinteractor100Archease (PF01951, IPR023572): Archease protein family (MTH1598/TM1083)

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