Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRKCH (from a repository: Wed Nov 16 08:20:25 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins3 (27.27 %)
The number (and %) of the tumor suppressors3 (27.27 %)
Total number of binary PPIs (saturation %)21 (38.18 %)
The number (and %) of affected PPIs11 (52.38 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.909
Assortativity coefficient-0.3143
The network average Clustering coefficient0.415
The number (and %) of a zero Clustering coefficients5 (45.45 %)
The number (and %) of a zero Betweenness Centrality8 (72.73 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PRKCH All fusions
Proteins found in more fusions HSP90AA1 (see 2 fusions); VHL (see 1 fusions); PRKCH (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PRKCHparental protein110.13373.667C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
2 AKAP13oncoprotein100APG6 (PF04111, IPR007243): Autophagy protein Apg6
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
RII_binding_1 (PF10522, IPR018459): RII binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
3 BANPsuppressor200DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
4 CDK2suppressor50.8330.667Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
5 GSK3Ainteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
6 HSP90AA1oncoprotein60.6003.667HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
7 MGMTinteractor31.0000DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
8 NFE2L2oncoprotein100bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
9 PPP1R14Ainteractor100PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
10 VHLsuppressor41.0000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
11 ZBTB8OSinteractor100Archease (PF01951, IPR023572): Archease protein family (MTH1598/TM1083)

B a c k    t o    T o p ⇑