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Fusion ID: Protein names:	PRKCH
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Visualization interactions

Cytoscape Web for: parental proteins PRKCH (from a repository: Wed Nov 16 08:20:25 2016)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	11
The number (and %) of the onco-proteins	3 (27.27 %)
The number (and %) of the tumor suppressors	3 (27.27 %)
Total number of binary PPIs (saturation %)	21 (38.18 %)
The number (and %) of affected PPIs	11 (52.38 %)
The number of possible different fusions	4
PPI diameter	2
PPI radius	1
The average degree of PPI	2.909
Assortativity coefficient	-0.3143
The network average Clustering coefficient	0.415
The number (and %) of a zero Clustering coefficients	5 (45.45 %)
The number (and %) of a zero Betweenness Centrality	8 (72.73 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PRKCH	All fusions
Proteins found in more fusions	HSP90AA1 (see 2 fusions); VHL (see 1 fusions); PRKCH (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PRKCH	parental protein	11	0.133	73.667	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
2	AKAP13	oncoprotein	1	0	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68) RII_binding_1 (PF10522, IPR018459): RII binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
3	BANP	suppressor	2	0	0	DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845) BEN (PF10523, IPR018379, SM01025): BEN domain
4	CDK2	suppressor	5	0.833	0.667	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
5	GSK3A	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
6	HSP90AA1	oncoprotein	6	0.600	3.667	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
7	MGMT	interactor	3	1.000	0	DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
8	NFE2L2	oncoprotein	1	0	0	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
9	PPP1R14A	interactor	1	0	0	PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
10	VHL	suppressor	4	1.000	0	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain
11	ZBTB8OS	interactor	1	0	0	Archease (PF01951, IPR023572): Archease protein family (MTH1598/TM1083)

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