Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRKCD (from a repository: Sat Dec 3 13:01:33 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 90 The number (and %) of the onco-proteins 31 (34.44 %) The number (and %) of the tumor suppressors 14 (15.56 %) Total number of binary PPIs (saturation %) 364 (9.09 %) The number (and %) of affected PPIs 90 (24.73 %) The number of possible different fusions 25 PPI diameter 2 PPI radius 1 The average degree of PPI 7.200 Assortativity coefficient -0.2823 The network average Clustering coefficient 0.497 The number (and %) of a zero Clustering coefficients 15 (16.67 %) The number (and %) of a zero Betweenness Centrality 31 (34.44 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PRKCD	All fusions : AI457515;
Proteins found in more fusions	STAT3 (see 2 fusions); APP (see 4 fusions); YWHAG (see 1 fusions); VCP (see 4 fusions); RANBP9 (see 2 fusions); TKT (see 5 fusions); HSP90AA1 (see 2 fusions); YWHAZ (see 1 fusions); HSPB1 (see 4 fusions); PRKCD (see 2 fusions); SHC1 (see 1 fusions); HDAC5 (see 1 fusions); IKBKB (see 2 fusions); EP300 (see 1 fusions); SQSTM1 (see 5 fusions); MTOR (see 1 fusions); FYN (see 1 fusions); STAT1 (see 1 fusions); VHL (see 1 fusions); MYC (see 1 fusions); SP1 (see 1 fusions); TP53 (see 3 fusions); IBTK (see 2 fusions); TNFRSF1A (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PRKCD	parental protein	90	0.060	6049.822	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
2	ACTBL2	interactor	3	1.000	0	Actin (PF00022, IPR004000, SM00268): Actin
3	ADAM9	oncoprotein	1	0	0	EB (PF01683, IPR006149): EB module Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
4	AFAP1	interactor	4	0.667	0.286	PH (PF00169, IPR001849, SM00233): PH domain Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Enkurin (PF13864, IPR027012): Calmodulin-binding
5	APP	protein found in more fusions	22	0.157	145.783	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6	ART3	interactor	1	0	0	ART (PF01129, IPR000768): NAD:arginine ADP-ribosyltransferase
7	BUD13	interactor	1	0	0	IncA (PF04156, IPR007285): IncA protein Bud13 (PF09736, IPR018609): Pre-mRNA-splicing factor of RES complex
8	C1QBP	interactor	5	0.600	1.733	MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
9	CHD9	oncoprotein	2	1.000	0	BUD22 (PF09073, IPR015158): BUD22 CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain Chorion_2 (PF03964, IPR005649): Chorion family 2 Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain cIII (PF08134, IPR012995): cIII protein family Peptidase_M10 (PF00413, IPR001818): Matrixin SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Vpu (PF00558, IPR008187): Vpu protein Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain BRK (PF07533, IPR006576, SM00592): BRK domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Sox_N (PF12444, IPR022151): Sox developmental protein N terminal FNIP_N (PF14636, IPR028084): Folliculin-interacting protein N-terminus
10	CHUK	suppressor	16	0.448	28.402	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
11	CWC15	interactor	2	1.000	0	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
12	DAB2	suppressor	4	0.500	1.889	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
13	DHX16	interactor	2	1.000	0	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF4629 (PF15442, IPR027898): Domain of unknown function (DUF4629)
14	DIABLO	suppressor	3	1.000	0	Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
15	DYNC1H1	interactor	5	0.600	1.833	AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily) DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1 DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1 AAA_7 (PF12775): P-loop containing dynein motor region D3 MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4 AAA_9 (PF12781): ATP-binding dynein motor region D5
16	ELAVL1	oncoprotein	14	0.256	44.805	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
17	EP300	oncoprotein	15	0.341	39.971	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
18	FAM192A	interactor	2	1.000	0	VIT1 (PF01988, IPR008217): VIT family Nefa_Nip30_N (PF10187, IPR019331): N-terminal domain of NEFA-interacting nuclear protein NIP30
19	FLI1	oncoprotein	1	0	0	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
20	FXR1	interactor	7	0.400	4.983	Agenet (PF05641, IPR008395, SM00743): Agenet domain KH_1 (PF00013, IPR004088, SM00322): KH domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2 FXR_C3 (PF16097, IPR032177): Fragile X-related 1 protein C-terminal region 3
21	FYN	oncoprotein	8	0.476	7.400	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
22	GABRA1	interactor	2	1.000	0	Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
23	GNA12	oncoprotein	4	0.833	0.222	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
24	GNA13	interactor	4	0.500	1.900	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
25	GRM5	interactor	1	0	0	7tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
26	GSK3A	interactor	5	0.700	0.869	Pkinase (PF00069, IPR000719): Protein kinase domain
27	H2BFS	interactor	1	0	0	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
28	HDAC5	protein found in more fusions	14	0.372	28.771	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
29	HIST1H1A	interactor	3	1.000	0	Mucin (PF01456, IPR000458): Mucin-like glycoprotein Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
30	HIST1H1B	oncoprotein	2	1.000	0	Pneumo_att_G (PF05539, IPR008781): Pneumovirinae attachment membrane glycoprotein G Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
31	HSP90AA1	oncoprotein	27	0.249	178.156	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
32	HSPA4	interactor	13	0.487	16.932	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
33	HSPB1	oncoprotein	17	0.425	41.883	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
34	IBTK	protein found in more fusions	3	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat Ank_5 (PF13857): Ankyrin repeats (many copies)
35	IKBKB	protein found in more fusions	14	0.449	23.529	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
36	IL32	interactor	2	0	0	IL32 (PF15225, IPR028067): Interleukin 32
37	IL6ST	oncoprotein	4	0.500	2.333	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
38	INPP5D	interactor	3	0.667	0.667	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SH2 (PF00017, IPR000980, SM00252): SH2 domain
39	INSR	interactor	5	0.400	5.000	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain
40	IRAK1	interactor	12	0.527	11.979	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
41	IRS1	interactor	7	0.429	10.000	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
42	ITGB2	interactor	5	0.400	4.500	EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain
43	ITPR1	interactor	2	1.000	0	Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor Ion_trans (PF00520, IPR005821): Ion transport protein MIR (PF02815, IPR016093, SM00472): MIR domain RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated RYDR_ITPR (PF01365, IPR000699): RIH domain CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
44	KLF4	suppressor	6	0.600	2.367	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
45	LYSMD2	interactor	1	0	0	LysM (PF01476, IPR018392, SM00257): LysM domain HCV_NS5a_C (PF12941, IPR024350): HCV NS5a protein C-terminal region
46	MACF1	oncoprotein	1	0	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain CTV_P33 (PF07184, IPR010803): Citrus tristeza virus P33 protein DnaI_N (PF07319, IPR009928): Primosomal protein DnaI N-terminus DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF19 (PF01579, IPR002542): Domain of unknown function (DUF19) FliJ (PF02050, IPR012823): Flagellar FliJ protein GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain Laminin_II (PF06009, IPR010307): Laminin Domain II Peptidase_S49 (PF01343, IPR002142): Peptidase family S49 Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Spectrin (PF00435, IPR002017): Spectrin repeat SYF2 (PF08231, IPR013260): SYF2 splicing factor KxDL (PF10241, IPR019371): Uncharacterized conserved protein Plectin (PF00681, IPR001101, SM00250): Plectin repeat Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like DUF3813 (PF12758, IPR024217): Protein of unknown function (DUF3813) EF-hand_7 (PF13499, IPR011992): EF-hand domain pair TEX12 (PF15219, IPR029193): Testis-expressed 12 HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
47	MTOR	oncoprotein	13	0.394	24.660	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
48	MUC1	oncoprotein	4	0.833	0.400	SEA (PF01390, IPR000082, SM00200): SEA domain Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator Collectrin (PF16959, IPR031588): Renal amino acid transporter
49	MYC	oncoprotein	22	0.257	116.360	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
50	NCF1	interactor	3	1.000	0	p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain PX (PF00787, IPR001683, SM00312): PX domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
51	NFE2L2	oncoprotein	4	0.667	1.500	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
52	NOTCH1	suppressor	7	0.467	6.667	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
53	PDP1	interactor	1	0	0	PP2C (PF00481, IPR001932): Protein phosphatase 2C
54	PDP2	interactor	1	0	0	PP2C (PF00481, IPR001932): Protein phosphatase 2C
55	PDPK1	interactor	5	0.500	0.908	Pkinase (PF00069, IPR000719): Protein kinase domain PH_3 (PF14593): PH domain
56	PHB	suppressor	6	0.800	1.500	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
57	PIK3CB	oncoprotein	2	1.000	0	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) RWD (PF05773, IPR006575, SM00591): RWD domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase Tom37_C (PF11801, IPR019564): Tom37 C-terminal domain DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
58	PLD2	interactor	3	0.667	0.500	PH (PF00169, IPR001849, SM00233): PH domain PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif PX (PF00787, IPR001683, SM00312): PX domain PLDc_2 (PF13091, IPR025202): PLD-like domain
59	PLSCR3	interactor	1	0	0	Scramblase (PF03803, IPR005552): Scramblase
60	PPP2CA	suppressor	9	0.472	10.057	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
61	PPRC1	interactor	1	0	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
62	PRKCB	suppressor	24	0.138	190.771	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
63	PRKCQ	interactor	10	0.333	16.917	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
64	PRPF4B	oncoprotein	3	0.667	0.250	Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking Ureide_permease (PF07168, IPR009834): Ureide permease Pkinase (PF00069, IPR000719): Protein kinase domain Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
65	PTGES3	interactor	6	0.900	0.333	CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
66	PTK2B	interactor	7	0.400	8.000	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
67	PTPN6	suppressor	4	0.500	2.667	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
68	RANBP10	interactor	2	1.000	0	LisH (PF08513, IPR013720, SM00667): LisH SPRY (PF00622, IPR003877, SM00449): SPRY domain CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
69	RANBP9	suppressor	8	0.333	9.883	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator LisH (PF08513, IPR013720, SM00667): LisH SPRY (PF00622, IPR003877, SM00449): SPRY domain CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
70	RASGRP3	interactor	4	0.500	0.908	RasGEF (PF00617, IPR001895, SM00147): RasGEF domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 (PF00036, IPR002048, SM00054): EF hand RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif EF-hand_6 (PF13405, IPR002048): EF-hand domain
71	RIPK4	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
72	RPL37A	interactor	3	0.667	0.250	Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
73	SHC1	oncoprotein	7	0.400	7.667	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
74	SNCA	interactor	10	0.500	10.919	Synuclein (PF01387, IPR001058): Synuclein
75	SP1	protein found in more fusions	10	0.611	7.850	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
76	SQSTM1	oncoprotein	13	0.439	24.386	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
77	STAT1	suppressor	8	0.476	4.752	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
78	STAT3	suppressor	11	0.356	18.574	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
79	TIAM1	oncoprotein	4	0.667	0.619	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) PH (PF00169, IPR001849, SM00233): PH domain RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain AAA_22 (PF13401, IPR003593): AAA domain
80	TKT	protein found in more fusions	8	0.619	3.221	Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
81	TNFRSF1A	oncoprotein	9	0.429	9.800	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
82	TP53	suppressor	22	0.333	92.988	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
83	TRAPPC13	interactor	1	0	0	DUF974 (PF06159, IPR010378): Protein of unknown function (DUF974) Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Trs65 (PF12735, IPR024662): TRAPP trafficking subunit Trs65
84	TRIM41	interactor	5	0.833	0.222	BUD22 (PF09073, IPR015158): BUD22 Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family RecR (PF02132, IPR023628): RecR protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain DUF3631 (PF12307, IPR022081): Protein of unknown function (DUF3631) zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
85	TRO	interactor	1	0	0	MAGE (PF01454, IPR002190): MAGE family DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533) AP3D1 (PF06375): AP-3 complex subunit delta-1
86	VCP	protein found in more fusions	18	0.331	63.343	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
87	VHL	suppressor	12	0.527	15.536	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain
88	YWHAG	protein found in more fusions	13	0.288	31.608	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
89	YWHAZ	protein found in more fusions	13	0.424	21.969	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
90	ZNF131	interactor	2	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain PVL_ORF50 (PF07768, IPR011688): PVL ORF-50-like family zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

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