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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)48
The number (and %) of the onco-proteins12 (25.00 %)
The number (and %) of the tumor suppressors6 (12.50 %)
Total number of binary PPIs (saturation %)154 (13.65 %)
The number (and %) of affected PPIs48 (31.17 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI5.542
Assortativity coefficient-0.3556
The network average Clustering coefficient0.446
The number (and %) of a zero Clustering coefficients14 (29.17 %)
The number (and %) of a zero Betweenness Centrality23 (47.92 %)


List of the fusions

PPI for parental proteins: PRDX4 All fusions
Proteins found in more fusions TUBG1 (see 1 fusions); PRDX4 (see 1 fusions); HUWE1 (see 2 fusions); HDAC5 (see 1 fusions); EWSR1 (see 2 fusions); CUL3 (see 1 fusions); PRDX1 (see 1 fusions); CSNK1E (see 1 fusions); NPM1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PRDX4parental protein480.0801733.052AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
2 A1BGinteractor100Ig_2 (PF13895, IPR007110): Immunoglobulin domain
3 ALG12interactor100Glyco_transf_22 (PF03901, IPR005599): Alg9-like mannosyltransferase family
4 APOBinteractor200DUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH)
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
5 BMI1oncoprotein80.4767.233zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
6 CFHR1interactor21.0000CFEM (PF05730, IPR008427, SM00747): CFEM domain
DUF1962 (PF09227, IPR015308): Domain of unknown function (DUF1962)
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
7 CFHR3interactor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
8 CLIC1interactor31.0000GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
9 CRY1interactor60.5002.400DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
10 CSNK1Eprotein found in more fusions50.6670.900APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
11 CUL2suppressor120.50019.086Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
12 CUL3protein found in more fusions130.51516.352Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
13 CYP27A1interactor100p450 (PF00067, IPR001128): Cytochrome P450
14 DUSP23interactor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
PTPlike_phytase (PF14566): Inositol hexakisphosphate
15 EEDsuppressor70.4007.900WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
16 ENO1oncoprotein90.50013.967Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
17 EWSR1oncoprotein100.50011.700RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 GLTPD2interactor100GLTP (PF08718, IPR014830): Glycolipid transfer protein (GLTP)
Herpes_LP (PF03363, IPR005030): Herpesvirus leader protein
DUF2786 (PF10979, IPR024498): Protein of unknown function (DUF2786)
19 H2AFXsuppressor70.4766.967Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
20 HDAC5protein found in more fusions40.6670.400Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
21 HDAC6oncoprotein50.5002.333Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
22 HUWE1oncoprotein90.5715.700BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
23 LBPinteractor21.0000LBP_BPI_CETP (PF01273, IPR017942, SM00328): LBP / BPI / CETP family, N-terminal domain
LBP_BPI_CETP_C (PF02886, IPR001124, SM00329): LBP / BPI / CETP family, C-terminal domain
24 MAP4K2oncoprotein100CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
25 MOV10interactor90.5289.000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
26 MRPL58interactor31.0000RF-1 (PF00472, IPR000352): RF-1 domain
27 MT-CO1interactor100NA
28 NPM1suppressor160.40042.086Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
29 NR4A1suppressor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
30 NTRK1oncoprotein150.36344.033I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
31 NXF1interactor110.37818.500NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
32 PLGinteractor21.0000Kringle (PF00051, IPR000001): Kringle domain
PAN_1 (PF00024, IPR003014): PAN domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
33 PRDX1oncoprotein100.41715.100AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
34 PRDX2interactor50.8000.900AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
35 PRDX3interactor90.46411.633AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
36 RCHY1suppressor200C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
37 SIRT7interactor80.5006.652DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
38 SULT2A1interactor100Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
39 TBXA2Rinteractor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
40 TCTN1interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
41 TERF1interactor40.6670.667TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
42 TERF2interactor70.4676.500Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
43 TLN1interactor60.5334.286DUF1013 (PF06242, IPR010421): Protein of unknown function (DUF1013)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Talin_middle (PF09141, IPR015224): Talin, middle domain
VBS (PF08913, IPR015009): Vinculin Binding Site
CoatB (PF10389, IPR008020): Bacteriophage coat protein B
LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM
44 TTF2interactor100SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
zf-GRF (PF06839, IPR010666): GRF zinc finger
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
45 TUBG1protein found in more fusions31.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
46 UBL4Ainteractor60.5332.652ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
47 VTNinteractor21.0000Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
48 ZNF593interactor100DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding

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