Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRDX1 (from a repository: Wed Nov 16 05:48:41 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 123 The number (and %) of the onco-proteins 44 (35.77 %) The number (and %) of the tumor suppressors 21 (17.07 %) Total number of binary PPIs (saturation %) 879 (11.72 %) The number (and %) of affected PPIs 123 (13.99 %) The number of possible different fusions 30 PPI diameter 2 PPI radius 1 The average degree of PPI 13.285 Assortativity coefficient -0.1982 The network average Clustering coefficient 0.488 The number (and %) of a zero Clustering coefficients 10 (8.13 %) The number (and %) of a zero Betweenness Centrality 20 (16.26 %)

ACTIVE INTERACTORS MISSING INTERACTORS (in fusions)

List of the fusions
PPI for parental proteins: PRDX1	All fusions : CN267646;
Proteins found in more fusions	CUL4A (see 4 fusions); TKT (see 5 fusions); EPS15 (see 1 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); PRDX4 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); LUC7L (see 1 fusions); VHL (see 1 fusions); MYC (see 1 fusions); NTRK1/TPM3 (see 3 fusions); NF2 (see 1 fusions); UBE2H (see 4 fusions); PRKDC (see 3 fusions); TRIM4 (see 1 fusions); PRDX1 (see 1 fusions); GAN (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); SKI (see 1 fusions); COPS5 (see 1 fusions); SHC1 (see 1 fusions); PRDX6 (see 1 fusions); FN1/RNH1 (see 1 fusions); RPA1 (see 1 fusions); DNPH1 (see 1 fusions); GAPDH (see 2 fusions); SUZ12 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PRDX1	parental protein	123	0.094	8908.610	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
2	ABL1	oncoprotein	13	0.470	17.668	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	ACAA2	interactor	6	0.733	1.619	Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4	ADH5	interactor	2	0	0	ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
5	AGO4	interactor	1	0	0	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
6	ANAPC15	interactor	3	1.000	0	Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
7	ARHGEF2	oncoprotein	9	0.611	3.622	IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
8	ASS1	suppressor	13	0.470	12.465	Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
9	BAX	suppressor	5	0.667	0.722	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
10	BTRC	oncoprotein	13	0.364	23.596	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
11	CACYBP	interactor	8	0.571	2.575	CS (PF04969, IPR007052): CS domain SGS (PF05002, IPR007699): SGS domain Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
12	CALM1	interactor	15	0.314	36.574	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
13	CAND1	interactor	26	0.483	52.892	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
14	CAT	suppressor	10	0.556	8.017	Catalase (PF00199, IPR011614, SM01060): Catalase Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
15	CCNB1	oncoprotein	10	0.422	9.411	Adeno_E1A (PF02703, IPR003853): Early E1A protein Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
16	CDC42	oncoprotein	5	0.833	0.125	Ras (PF00071, IPR001806, SM00173): Ras family
17	CDK2	suppressor	29	0.415	64.616	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
18	CFL1	interactor	28	0.320	135.779	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
19	CLEC4G	interactor	1	0	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
20	COPS5	protein found in more fusions	25	0.591	27.050	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
21	COPS6	interactor	20	0.614	24.225	DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
22	CRY1	interactor	11	0.333	13.712	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
23	CUL1	suppressor	32	0.387	118.530	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24	CUL2	suppressor	21	0.590	21.519	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25	CUL3	protein found in more fusions	35	0.355	156.943	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
26	CUL4A	protein found in more fusions	17	0.567	22.292	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27	CUL4B	oncoprotein	21	0.619	18.341	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
28	CUL5	suppressor	20	0.647	14.410	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
29	CUL7	protein found in more fusions	19	0.366	25.324	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
30	DAB2	suppressor	2	1.000	0	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
31	DAZAP1	interactor	25	0.303	80.326	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
32	DCUN1D1	interactor	18	0.673	11.843	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
33	DNPH1	protein found in more fusions	3	1.000	0	Nuc_deoxyrib_tr (PF05014, IPR007710): Nucleoside 2-deoxyribosyltransferase
34	EGFR	oncoprotein	25	0.319	95.504	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
35	EIF4A3	interactor	19	0.392	36.253	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
36	EPS15	oncoprotein	11	0.400	14.623	Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
37	FERMT3	interactor	5	0.600	1.052	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
38	FN1	oncoprotein	32	0.268	169.768	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
39	FSCN1	oncoprotein	12	0.485	11.725	Fascin (PF06268, IPR022768): Fascin domain
40	FUS	suppressor	34	0.373	140.397	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
41	GAN	protein found in more fusions	4	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
42	GAPDH	oncoprotein	41	0.315	243.146	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
43	HECTD1	interactor	4	0.667	0.500	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein MIB_HERC2 (PF06701, IPR010606): Mib_herc2 NOA36 (PF06524, IPR010531): NOA36 protein Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
44	HNRNPA1	interactor	38	0.380	169.390	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
45	IKBKAP	interactor	10	0.556	7.889	IKI3 (PF04762, IPR006849): IKI3 family Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
46	IQCB1	interactor	7	0.286	10.065	DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765) IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
47	IRF3	suppressor	3	1.000	0	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
48	ISG15	suppressor	7	0.524	2.935	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
49	ITGA4	interactor	21	0.426	31.666	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
50	LAP3	interactor	6	0.667	1.327	Peptidase_M17 (PF00883, IPR000819): Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N (PF02789, IPR008283): Cytosol aminopeptidase family, N-terminal domain PAW (PF04721, IPR006588, SM00613): PNGase C-terminal domain, mannose-binding module PAW
51	LOC440434	interactor	1	0	0	NA
52	LUC7L	protein found in more fusions	6	0.700	1.233	LUC7 (PF03194, IPR004882): LUC7 N_terminus Hid1 (PF12722): High-temperature-induced dauer-formation protein
53	MAGOH	interactor	5	0.700	1.167	Mago_nashi (PF02792, IPR004023): Mago nashi protein
54	MCM2	oncoprotein	36	0.324	187.787	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
55	MCM5	oncoprotein	12	0.652	6.198	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
56	METTL1	interactor	6	0.400	6.367	Methyltransf_4 (PF02390, IPR003358): Putative methyltransferase
57	MPG	interactor	7	0.476	7.933	Pur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG)
58	MPP1	oncoprotein	4	0.833	0.286	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
59	MSH6	oncoprotein	7	0.524	3.343	MutS_I (PF01624, IPR007695): MutS domain I MutS_II (PF05188, IPR007860): MutS domain II PWWP (PF00855, IPR000313, SM00293): PWWP domain MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III UPF0524 (PF15823, IPR029670): UPF0524 of C3orf70
60	MTRNR2L1	interactor	1	0	0	Humanin (PF15040, IPR028139): Humanin family
61	MYC	oncoprotein	20	0.304	63.361	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
62	MYD88	oncoprotein	3	1.000	0	Death (PF00531, IPR000488, SM00005): Death domain TIR (PF01582, IPR000157, SM00255): TIR domain
63	NANS	interactor	6	0.733	0.657	NeuB (PF03102, IPR013132): NeuB family SAF (PF08666, IPR013974, SM00858): SAF domain
64	NEDD8	interactor	24	0.494	54.004	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
65	NF2	suppressor	6	0.500	2.519	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
66	NTRK1	oncoprotein	51	0.204	600.615	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
67	OBSL1	interactor	17	0.450	15.133	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
68	OTUB1	interactor	12	0.333	24.824	Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
69	PARK2	suppressor	15	0.363	29.524	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
70	PEBP1	suppressor	6	0.667	3.333	PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
71	PIDD1	interactor	2	1.000	0	Death (PF00531, IPR000488, SM00005): Death domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain Peptidase_S68 (PF10461, IPR019502): Peptidase S68 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
72	PPP2R1A	oncoprotein	18	0.340	45.488	TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
73	PPP2R1B	suppressor	7	0.733	1.352	HEAT (PF02985, IPR000357): HEAT repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_2 (PF13646): HEAT repeats
74	PPP2R5D	interactor	8	0.464	8.266	B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
75	PPT1	interactor	4	0.667	1.250	Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
76	PRDX2	interactor	41	0.177	466.267	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
77	PRDX3	interactor	22	0.310	57.805	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
78	PRDX4	protein found in more fusions	10	0.417	9.844	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
79	PRDX5	interactor	15	0.333	45.286	Redoxin (PF08534, IPR013740): Redoxin NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
80	PRDX6	protein found in more fusions	16	0.305	26.082	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
81	PRKDC	protein found in more fusions	32	0.258	197.379	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
82	PTEN	suppressor	5	0.500	1.397	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
83	RAB4B	oncoprotein	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family
84	RAD23A	oncoprotein	8	0.381	10.833	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
85	RAD52	oncoprotein	8	0.810	0.924	Rad52_Rad22 (PF04098, IPR007232): Rad52/22 family double-strand break repair protein DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
86	RNH1	suppressor	6	0.600	2.139	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat Metallothio_Euk (PF12749, IPR024306): Eukaryotic metallothionein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
87	RPA1	suppressor	23	0.424	61.923	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
88	RPA2	oncoprotein	21	0.419	53.137	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
89	RPA3	interactor	18	0.500	23.201	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
90	RPS6KB2	interactor	7	0.619	2.833	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
91	SESN1	interactor	1	0	0	PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
92	SESN2	interactor	1	0	0	PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
93	SH2D1B	interactor	1	0	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain
94	SH3BGRL2	oncoprotein	2	1.000	0	SH3BGR (PF04908, IPR006993): SH3-binding, glutamic acid-rich protein
95	SHC1	oncoprotein	7	0.933	0.400	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
96	SKI	oncoprotein	3	1.000	0	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
97	SMARCD1	interactor	3	0.667	0.400	ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit DivIC (PF04977, IPR007060): Septum formation initiator SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
98	SNCA	interactor	10	0.472	9.093	Synuclein (PF01387, IPR001058): Synuclein
99	SOD1	interactor	14	0.462	22.290	Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
100	SPR	interactor	9	0.528	7.266	adh_short (PF00106, IPR002198): short chain dehydrogenase
101	SUZ12	suppressor	9	0.357	9.495	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
102	TANGO2	interactor	5	0.900	0.250	TANGO2 (PF05742, IPR008551): Transport and Golgi organisation 2
103	TERF1	interactor	14	0.346	28.700	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
104	TIPIN	interactor	3	1.000	0	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Swi3 (PF07962, IPR012923): Replication Fork Protection Component Swi3 CEP19 (PF14933, IPR029412): CEP19-like protein
105	TIPRL	interactor	6	0.667	1.507	TIP41 (PF04176, IPR007303): TIP41-like family
106	TKT	protein found in more fusions	23	0.372	63.679	Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
107	TPM3	oncoprotein	11	0.422	5.066	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
108	TRIM4	protein found in more fusions	2	0	0	SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Fasciclin (PF02469, IPR000782, SM00554): Fasciclin domain PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
109	TSNAX	interactor	3	0.667	1.000	Translin (PF01997, IPR002848): Translin family
110	TXN	oncoprotein	24	0.322	102.812	Thioredoxin (PF00085, IPR013766): Thioredoxin
111	U2AF2	protein found in more fusions	22	0.424	49.864	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
112	UBE2H	protein found in more fusions	5	0.500	1.567	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
113	UBE2M	interactor	16	0.448	14.408	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
114	UBE3A	oncoprotein	8	0.429	7.752	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
115	UBL4A	interactor	5	0.600	1.376	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
116	UCHL5	oncoprotein	12	0.382	17.176	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
117	URM1	interactor	3	0.667	0.667	Urm1 (PF09138, IPR015221): Urm1 (Ubiquitin related modifier)
118	USP5	interactor	5	0.400	4.400	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
119	VCAM1	interactor	20	0.347	37.234	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
120	VHL	suppressor	14	0.526	11.082	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain
121	YAP1	suppressor	9	0.361	18.800	Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181
122	YWHAQ	interactor	30	0.301	174.826	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
123	ZFR	interactor	11	0.527	8.151	DZF (PF07528, IPR006561, SM00572): DZF domain K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence zf-met (PF12874): Zinc-finger of C2H2 type

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List of missing interactors (in fusions)

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	LOC440434	interactor	NA	CN267646
2	PRDX1	parental protein	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin	CN267646

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