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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRDX1 (from a repository: Wed Nov 16 05:48:41 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)123
The number (and %) of the onco-proteins44 (35.77 %)
The number (and %) of the tumor suppressors21 (17.07 %)
Total number of binary PPIs (saturation %)879 (11.72 %)
The number (and %) of affected PPIs123 (13.99 %)
The number of possible different fusions30
PPI diameter2
PPI radius1
The average degree of PPI13.285
Assortativity coefficient-0.1982
The network average Clustering coefficient0.488
The number (and %) of a zero Clustering coefficients10 (8.13 %)
The number (and %) of a zero Betweenness Centrality20 (16.26 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: PRDX1 All fusions
: CN267646;
Proteins found in more fusions CUL4A (see 4 fusions); TKT (see 5 fusions); EPS15 (see 1 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); PRDX4 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); LUC7L (see 1 fusions); VHL (see 1 fusions); MYC (see 1 fusions); NTRK1/TPM3 (see 3 fusions); NF2 (see 1 fusions); UBE2H (see 4 fusions); PRKDC (see 3 fusions); TRIM4 (see 1 fusions); PRDX1 (see 1 fusions); GAN (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); SKI (see 1 fusions); COPS5 (see 1 fusions); SHC1 (see 1 fusions); PRDX6 (see 1 fusions); FN1/RNH1 (see 1 fusions); RPA1 (see 1 fusions); DNPH1 (see 1 fusions); GAPDH (see 2 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PRDX1parental protein1230.0948908.610AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
2 ABL1oncoprotein130.47017.668Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3 ACAA2interactor60.7331.619Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ADH5interactor200ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
5 AGO4interactor100ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
6 ANAPC15interactor31.0000Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
7 ARHGEF2oncoprotein90.6113.622IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
8 ASS1suppressor130.47012.465Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
9 BAXsuppressor50.6670.722Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
10 BTRConcoprotein130.36423.596WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
11 CACYBPinteractor80.5712.575CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
12 CALM1interactor150.31436.574EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
13 CAND1interactor260.48352.892Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
14 CATsuppressor100.5568.017Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
15 CCNB1oncoprotein100.4229.411Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
16 CDC42oncoprotein50.8330.125Ras (PF00071, IPR001806, SM00173): Ras family
17 CDK2suppressor290.41564.616Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
18 CFL1interactor280.320135.779Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
19 CLEC4Ginteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
20 COPS5protein found in more fusions250.59127.050JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
21 COPS6interactor200.61424.225DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
22 CRY1interactor110.33313.712DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
23 CUL1suppressor320.387118.530Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24 CUL2suppressor210.59021.519Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25 CUL3protein found in more fusions350.355156.943Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
26 CUL4Aprotein found in more fusions170.56722.292Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27 CUL4Boncoprotein210.61918.341Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
28 CUL5suppressor200.64714.410Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
29 CUL7protein found in more fusions190.36625.324ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
30 DAB2suppressor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
31 DAZAP1interactor250.30380.326RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
32 DCUN1D1interactor180.67311.843Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
33 DNPH1protein found in more fusions31.0000Nuc_deoxyrib_tr (PF05014, IPR007710): Nucleoside 2-deoxyribosyltransferase
34 EGFRoncoprotein250.31995.504Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
35 EIF4A3interactor190.39236.253DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
36 EPS15oncoprotein110.40014.623Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
37 FERMT3interactor50.6001.052FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
38 FN1oncoprotein320.268169.768fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
39 FSCN1oncoprotein120.48511.725Fascin (PF06268, IPR022768): Fascin domain
40 FUSsuppressor340.373140.397Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
41 GANprotein found in more fusions41.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
42 GAPDHoncoprotein410.315243.146Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
43 HECTD1interactor40.6670.500Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
NOA36 (PF06524, IPR010531): NOA36 protein
Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
44 HNRNPA1interactor380.380169.390RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
45 IKBKAPinteractor100.5567.889IKI3 (PF04762, IPR006849): IKI3 family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
46 IQCB1interactor70.28610.065DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
47 IRF3suppressor31.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
48 ISG15suppressor70.5242.935ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
49 ITGA4interactor210.42631.666FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
50 LAP3interactor60.6671.327Peptidase_M17 (PF00883, IPR000819): Cytosol aminopeptidase family, catalytic domain
Peptidase_M17_N (PF02789, IPR008283): Cytosol aminopeptidase family, N-terminal domain
PAW (PF04721, IPR006588, SM00613): PNGase C-terminal domain, mannose-binding module PAW
51 LOC440434interactor100NA
52 LUC7Lprotein found in more fusions60.7001.233LUC7 (PF03194, IPR004882): LUC7 N_terminus
Hid1 (PF12722): High-temperature-induced dauer-formation protein
53 MAGOHinteractor50.7001.167Mago_nashi (PF02792, IPR004023): Mago nashi protein
54 MCM2oncoprotein360.324187.787AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
55 MCM5oncoprotein120.6526.198MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
56 METTL1interactor60.4006.367Methyltransf_4 (PF02390, IPR003358): Putative methyltransferase
57 MPGinteractor70.4767.933Pur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG)
58 MPP1oncoprotein40.8330.286PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
59 MSH6oncoprotein70.5243.343MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
PWWP (PF00855, IPR000313, SM00293): PWWP domain
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
UPF0524 (PF15823, IPR029670): UPF0524 of C3orf70
60 MTRNR2L1interactor100Humanin (PF15040, IPR028139): Humanin family
61 MYConcoprotein200.30463.361HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
62 MYD88oncoprotein31.0000Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
63 NANSinteractor60.7330.657NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
64 NEDD8interactor240.49454.004ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
65 NF2suppressor60.5002.519ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
66 NTRK1oncoprotein510.204600.615I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
67 OBSL1interactor170.45015.133BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
68 OTUB1interactor120.33324.824Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
69 PARK2suppressor150.36329.524IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
70 PEBP1suppressor60.6673.333PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
71 PIDD1interactor21.0000Death (PF00531, IPR000488, SM00005): Death domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
Peptidase_S68 (PF10461, IPR019502): Peptidase S68
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
72 PPP2R1Aoncoprotein180.34045.488TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
73 PPP2R1Bsuppressor70.7331.352HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
74 PPP2R5Dinteractor80.4648.266B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
75 PPT1interactor40.6671.250Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
76 PRDX2interactor410.177466.267AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
77 PRDX3interactor220.31057.805AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
78 PRDX4protein found in more fusions100.4179.844AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
79 PRDX5interactor150.33345.286Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
80 PRDX6protein found in more fusions160.30526.082AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
81 PRKDCprotein found in more fusions320.258197.379FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
82 PTENsuppressor50.5001.397DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
83 RAB4Boncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
84 RAD23Aoncoprotein80.38110.833UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
85 RAD52oncoprotein80.8100.924Rad52_Rad22 (PF04098, IPR007232): Rad52/22 family double-strand break repair protein
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
86 RNH1suppressor60.6002.139LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Metallothio_Euk (PF12749, IPR024306): Eukaryotic metallothionein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
87 RPA1suppressor230.42461.923Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
88 RPA2oncoprotein210.41953.137RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
89 RPA3interactor180.50023.201Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
90 RPS6KB2interactor70.6192.833Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
91 SESN1interactor100PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
92 SESN2interactor100PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
93 SH2D1Binteractor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
94 SH3BGRL2oncoprotein21.0000SH3BGR (PF04908, IPR006993): SH3-binding, glutamic acid-rich protein
95 SHC1oncoprotein70.9330.400PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
96 SKIoncoprotein31.0000c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
97 SMARCD1interactor30.6670.400ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
DivIC (PF04977, IPR007060): Septum formation initiator
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
98 SNCAinteractor100.4729.093Synuclein (PF01387, IPR001058): Synuclein
99 SOD1interactor140.46222.290Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
100 SPRinteractor90.5287.266adh_short (PF00106, IPR002198): short chain dehydrogenase
101 SUZ12suppressor90.3579.495DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
102 TANGO2interactor50.9000.250TANGO2 (PF05742, IPR008551): Transport and Golgi organisation 2
103 TERF1interactor140.34628.700TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
104 TIPINinteractor31.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Swi3 (PF07962, IPR012923): Replication Fork Protection Component Swi3
CEP19 (PF14933, IPR029412): CEP19-like protein
105 TIPRLinteractor60.6671.507TIP41 (PF04176, IPR007303): TIP41-like family
106 TKTprotein found in more fusions230.37263.679Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
107 TPM3oncoprotein110.4225.066Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
108 TRIM4protein found in more fusions200SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Fasciclin (PF02469, IPR000782, SM00554): Fasciclin domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
109 TSNAXinteractor30.6671.000Translin (PF01997, IPR002848): Translin family
110 TXNoncoprotein240.322102.812Thioredoxin (PF00085, IPR013766): Thioredoxin
111 U2AF2protein found in more fusions220.42449.864RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
112 UBE2Hprotein found in more fusions50.5001.567UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
113 UBE2Minteractor160.44814.408UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
114 UBE3Aoncoprotein80.4297.752HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
115 UBL4Ainteractor50.6001.376ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
116 UCHL5oncoprotein120.38217.176Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
117 URM1interactor30.6670.667Urm1 (PF09138, IPR015221): Urm1 (Ubiquitin related modifier)
118 USP5interactor50.4004.400UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
119 VCAM1interactor200.34737.234C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
120 VHLsuppressor140.52611.082Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
121 YAP1suppressor90.36118.800Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
122 YWHAQinteractor300.301174.82614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
123 ZFRinteractor110.5278.151DZF (PF07528, IPR006561, SM00572): DZF domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
zf-met (PF12874): Zinc-finger of C2H2 type

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 LOC440434interactorNACN267646
2 PRDX1parental proteinAhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
CN267646

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