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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PPP2R5E (from a repository: Sun Dec 4 19:39:46 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)43
The number (and %) of the onco-proteins16 (37.21 %)
The number (and %) of the tumor suppressors9 (20.93 %)
Total number of binary PPIs (saturation %)168 (18.60 %)
The number (and %) of affected PPIs43 (25.60 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI6.698
Assortativity coefficient-0.3656
The network average Clustering coefficient0.580
The number (and %) of a zero Clustering coefficients8 (18.60 %)
The number (and %) of a zero Betweenness Centrality17 (39.53 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PPP2R5E All fusions
Proteins found in more fusions TERF2IP (see 1 fusions); PPP2R5E (see 1 fusions); APP (see 4 fusions); MARK2 (see 2 fusions); CRY2 (see 3 fusions); TPD52L2 (see 2 fusions); CSNK1E (see 1 fusions); EGFR (see 2 fusions); ZDHHC17 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PPP2R5Eparental protein430.1181231.587B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
2 AARSinteractor31.0000DHHA1 (PF02272, IPR003156): DHHA1 domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
3 API5interactor30.6670.500API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
4 APPprotein found in more fusions140.23154.233APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 BHLHE41suppressor120.7095.968Adeno_PIX (PF03955, IPR005641): Adenovirus hexon-associated protein (IX)
Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
6 CBX5suppressor41.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
7 CCNG1oncoprotein31.0000Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
8 CDC20oncoprotein60.7001.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
9 CDK17interactor30.6670.500Pkinase (PF00069, IPR000719): Protein kinase domain
10 CHEK2suppressor70.6672.500FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
11 CLOCKinteractor100.8002.983DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PAS (PF00989, IPR013767, SM00091): PAS fold
RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
PAS_11 (PF14598): PAS domain
FlgT_N (PF16548, IPR032370): Flagellar assembly protein T, N-terminal domain
12 CRY1interactor110.7783.379DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
13 CRY2protein found in more fusions100.7783.108DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
14 CSNK1Eprotein found in more fusions130.54519.394APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
15 CSNK2Binteractor110.7114.875CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
16 DCLRE1Cinteractor100DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase
DUF3290 (PF11694, IPR021707): Protein of unknown function (DUF3290)
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
17 DEC1suppressor130.6977.402DEC1 (PF15859, IPR031718): Deleted in esophageal cancer 1 family
18 DNASE2Binteractor100DNase_II (PF03265, IPR004947): Deoxyribonuclease II
19 EGFRoncoprotein70.7332.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
20 ELAVL1oncoprotein80.38110.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 FAM43Ainteractor31.0000PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
22 FBXW11interactor80.6194.556WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
23 IKinteractor31.0000Lsm_interact (PF05391, IPR008669): Lsm interaction motif
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
RED_N (PF07808, IPR012916): RED-like protein N-terminal region
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
24 MARK2protein found in more fusions31.0000DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
25 MOSoncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
26 NANOGinteractor200Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
27 NOD2interactor200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
28 PPP1CAsuppressor60.9330.222Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
29 PPP2CAsuppressor110.52715.808Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
30 PPP2CBsuppressor110.47321.252Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
31 PPP2R1Aoncoprotein150.38146.760TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
32 PPP2R1Bsuppressor170.44246.498HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
33 PPP2R5Csuppressor110.43623.667B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
DUF1616 (PF07760, IPR011674): Protein of unknown function (DUF1616)
34 RORConcoprotein90.6944.141zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
35 SAE1interactor50.6003.667ThiF (PF00899, IPR000594): ThiF family
36 SAMHD1interactor50.8330.333HD (PF01966, IPR006674): HD domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
37 SMAD9interactor200MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
38 TERF2IPprotein found in more fusions200BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
39 TPD52L2protein found in more fusions50.8330.667TPD52 (PF04201, IPR007327): Tumour protein D52 family
40 TRMT10Aoncoprotein21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
tRNA_m1G_MT (PF01746, IPR016009): tRNA (Guanine-1)-methyltransferase
41 VTI1Binteractor100Fusion_gly (PF00523, IPR000776): Fusion glycoprotein F0
V-SNARE (PF05008, IPR007705): Vesicle transport v-SNARE protein N-terminus
V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
42 WNT3Aoncoprotein21.0000wnt (PF00110, IPR005817, SM00097): wnt family
43 ZDHHC17protein found in more fusions31.0000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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