1 |
PPFIA1 | parental protein | 50 | 0.079 | 1838.369 | HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 Cluap1 (PF10234, IPR019366): Clusterin-associated protein-1 TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus FAM76 (PF16046, IPR032017): FAM76 protein CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour |
2 |
AGTPBP1 | interactor | 1 | 0 | 0 | Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H |
3 |
AMOT | oncoprotein | 5 | 0.833 | 0.500 | FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162) Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
4 |
AURKB | interactor | 6 | 0.500 | 3.167 | Pkinase (PF00069, IPR000719): Protein kinase domain |
5 |
BRCA1 | suppressor | 8 | 0.286 | 13.833 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT |
6 |
C16orf70 | interactor | 1 | 0 | 0 | UPF0183 (PF03676, IPR005373): Uncharacterised protein family (UPF0183) |
7 |
CAGE1 | oncoprotein | 1 | 0 | 0 | ZapB (PF06005, IPR009252): Cell division protein ZapB Spectrin (PF00435, IPR002017): Spectrin repeat DUF2209 (PF09974, IPR014514): Uncharacterized protein conserved in archaea (DUF2209) Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family |
8 |
CCNH | oncoprotein | 2 | 1.000 | 0 | 5_3_exonuc_N (PF02739, IPR020046): 5'-3' exonuclease, N-terminal resolvase-like domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain |
9 |
CDC5L | interactor | 12 | 0.364 | 25.750 | OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
10 |
CDKN1A | suppressor | 6 | 0.467 | 5.900 | CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor |
11 |
CEP70 | protein found in more fusions | 3 | 1.000 | 0 | IncA (PF04156, IPR007285): IncA protein Mog1 (PF04603, IPR007681): Ran-interacting Mog1 protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin |
12 |
CUL2 | suppressor | 2 | 1.000 | 0 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
13 |
CYP4X1 | interactor | 1 | 0 | 0 | p450 (PF00067, IPR001128): Cytochrome P450 |
14 |
DROSHA | interactor | 1 | 0 | 0 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain Ribonucleas_3_3 (PF14622, IPR000999): Ribonuclease-III-like DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) |
15 |
DTNB | interactor | 4 | 0.667 | 1.000 | EF-hand_2 (PF09068, IPR015153): EF hand EF-hand_3 (PF09069, IPR015154): EF-hand Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type SOGA (PF11365, IPR027881): Protein SOGA |
16 |
ERC2 | oncoprotein | 5 | 0.800 | 1.333 | 3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation |
17 |
FAM161A | interactor | 4 | 0.667 | 1.000 | YajC (PF02699, IPR003849): Preprotein translocase subunit UPF0564 (PF10595, IPR019579): Uncharacterised protein family UPF0564 |
18 |
GBA2 | interactor | 1 | 0 | 0 | DUF608 (PF04685, IPR006775): Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N (PF12215, IPR024462): beta-glucosidase 2, glycosyl-hydrolase family 116 N-term |
19 |
GIT1 | interactor | 8 | 0.619 | 5.369 | ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) FlxA (PF14282, IPR025577): FlxA-like protein GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor |
20 |
GPS2 | oncoprotein | 2 | 1.000 | 0 | G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor |
21 |
GRIP2 | interactor | 3 | 1.000 | 0 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) |
22 |
IKBKG | interactor | 5 | 0.500 | 2.167 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
23 |
ING4 | suppressor | 2 | 0 | 0 | PHD (PF00628, IPR019787, SM00249): PHD-finger SOGA (PF11365, IPR027881): Protein SOGA ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-HC5HC2H (PF13771): PHD-like zinc-binding domain |
24 |
LATS2 | suppressor | 7 | 0.600 | 4.167 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
25 |
MBIP | interactor | 3 | 1.000 | 0 | DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192) |
26 |
NCOA2 | oncoprotein | 2 | 1.000 | 0 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein |
27 |
NDN | suppressor | 2 | 0 | 0 | MAGE (PF01454, IPR002190): MAGE family |
28 |
NTRK1 | oncoprotein | 21 | 0.216 | 130.267 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
29 |
OSBP | interactor | 2 | 1.000 | 0 | Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein PH (PF00169, IPR001849, SM00233): PH domain Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion |
30 |
PPFIA2 | interactor | 13 | 0.379 | 28.267 | DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745) HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SlyX (PF04102, IPR007236): SlyX TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour |
31 |
PPFIA3 | interactor | 13 | 0.394 | 28.700 | DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745) T2SSF (PF00482, IPR018076): Type II secretion system (T2SS), protein F SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) Tup_N (PF08581, IPR013890): Tup N-terminal FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 FAM76 (PF16046, IPR032017): FAM76 protein |
32 |
PPFIBP1 | oncoprotein | 9 | 0.500 | 9.869 | DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain XkdW (PF09636, IPR019094): XkdW protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding DUF3837 (PF12939, IPR024212): Domain of unknown function (DUF3837) |
33 |
PPFIBP2 | interactor | 3 | 0.667 | 1.000 | DASH_Dad1 (PF08649, IPR013958): DASH complex subunit Dad1 DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
34 |
PPP2CA | suppressor | 11 | 0.364 | 27.602 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
35 |
PPP2CB | suppressor | 5 | 0.900 | 0.400 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
36 |
PPP2R1A | oncoprotein | 10 | 0.533 | 12.236 | TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
37 |
PPP2R5D | interactor | 7 | 0.619 | 4.800 | B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family) |
38 |
PSMC4 | interactor | 6 | 0.933 | 0.333 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) NTPase_1 (PF03266, IPR004948): NTPase CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_16 (PF13191): AAA ATPase domain |
39 |
PSMD1 | interactor | 7 | 0.762 | 2.667 | PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat HEAT_2 (PF13646): HEAT repeats |
40 |
PSMD13 | interactor | 6 | 0.933 | 0.333 | Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase PCI (PF01399, IPR000717, SM00088): PCI domain |
41 |
PSMD8 | interactor | 6 | 0.800 | 1.500 | CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family |
42 |
PTPRD | suppressor | 4 | 1.000 | 0 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Glyco_hydro_46 (PF01374, IPR000400): Glycosyl hydrolase family 46 I-set (PF07679, IPR013098): Immunoglobulin I-set domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase Ig_3 (PF13927): Immunoglobulin domain |
43 |
PTPRF | interactor | 6 | 0.667 | 2.102 | Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST) C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377) |
44 |
PTPRS | interactor | 5 | 0.700 | 1.536 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase Ig_3 (PF13927): Immunoglobulin domain |
45 |
SPTAN1 | oncoprotein | 3 | 1.000 | 0 | EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain |
46 |
TNNT1 | protein found in more fusions | 2 | 0 | 0 | Troponin (PF00992, IPR001978): Troponin DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050) |
47 |
TUBG1 | protein found in more fusions | 7 | 0.467 | 5.833 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
48 |
TXLNA | protein found in more fusions | 6 | 0.400 | 5.500 | Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase |
49 |
XRCC1 | interactor | 2 | 1.000 | 0 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain SPX (PF03105, IPR004331): SPX domain XRCC1_N (PF01834, IPR002706): XRCC1 N terminal domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
50 |
YWHAB | interactor | 4 | 0.833 | 0.500 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |