Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PPFIA1 (from a repository: Tue Dec 6 02:07:01 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 50 The number (and %) of the onco-proteins 14 (28.00 %) The number (and %) of the tumor suppressors 9 (18.00 %) Total number of binary PPIs (saturation %) 163 (13.31 %) The number (and %) of affected PPIs 50 (30.67 %) The number of possible different fusions 7 PPI diameter 2 PPI radius 1 The average degree of PPI 5.680 Assortativity coefficient -0.2769 The network average Clustering coefficient 0.569 The number (and %) of a zero Clustering coefficients 9 (18.00 %) The number (and %) of a zero Betweenness Centrality 20 (40.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PPFIA1	All fusions : AA730788; BQ307279;
Proteins found in more fusions	TUBG1 (see 1 fusions); TXLNA (see 3 fusions); PPFIBP1 (see 1 fusions); CEP70 (see 1 fusions); TNNT1 (see 1 fusions); PPFIA1 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PPFIA1	parental protein	50	0.079	1838.369	HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 Cluap1 (PF10234, IPR019366): Clusterin-associated protein-1 TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus FAM76 (PF16046, IPR032017): FAM76 protein CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
2	AGTPBP1	interactor	1	0	0	Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
3	AMOT	oncoprotein	5	0.833	0.500	FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162) Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
4	AURKB	interactor	6	0.500	3.167	Pkinase (PF00069, IPR000719): Protein kinase domain
5	BRCA1	suppressor	8	0.286	13.833	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6	C16orf70	interactor	1	0	0	UPF0183 (PF03676, IPR005373): Uncharacterised protein family (UPF0183)
7	CAGE1	oncoprotein	1	0	0	ZapB (PF06005, IPR009252): Cell division protein ZapB Spectrin (PF00435, IPR002017): Spectrin repeat DUF2209 (PF09974, IPR014514): Uncharacterized protein conserved in archaea (DUF2209) Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
8	CCNH	oncoprotein	2	1.000	0	5_3_exonuc_N (PF02739, IPR020046): 5'-3' exonuclease, N-terminal resolvase-like domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
9	CDC5L	interactor	12	0.364	25.750	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
10	CDKN1A	suppressor	6	0.467	5.900	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
11	CEP70	protein found in more fusions	3	1.000	0	IncA (PF04156, IPR007285): IncA protein Mog1 (PF04603, IPR007681): Ran-interacting Mog1 protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin
12	CUL2	suppressor	2	1.000	0	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
13	CYP4X1	interactor	1	0	0	p450 (PF00067, IPR001128): Cytochrome P450
14	DROSHA	interactor	1	0	0	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain Ribonucleas_3_3 (PF14622, IPR000999): Ribonuclease-III-like DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
15	DTNB	interactor	4	0.667	1.000	EF-hand_2 (PF09068, IPR015153): EF hand EF-hand_3 (PF09069, IPR015154): EF-hand Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type SOGA (PF11365, IPR027881): Protein SOGA
16	ERC2	oncoprotein	5	0.800	1.333	3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
17	FAM161A	interactor	4	0.667	1.000	YajC (PF02699, IPR003849): Preprotein translocase subunit UPF0564 (PF10595, IPR019579): Uncharacterised protein family UPF0564
18	GBA2	interactor	1	0	0	DUF608 (PF04685, IPR006775): Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N (PF12215, IPR024462): beta-glucosidase 2, glycosyl-hydrolase family 116 N-term
19	GIT1	interactor	8	0.619	5.369	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) FlxA (PF14282, IPR025577): FlxA-like protein GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
20	GPS2	oncoprotein	2	1.000	0	G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
21	GRIP2	interactor	3	1.000	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
22	IKBKG	interactor	5	0.500	2.167	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
23	ING4	suppressor	2	0	0	PHD (PF00628, IPR019787, SM00249): PHD-finger SOGA (PF11365, IPR027881): Protein SOGA ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
24	LATS2	suppressor	7	0.600	4.167	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
25	MBIP	interactor	3	1.000	0	DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
26	NCOA2	oncoprotein	2	1.000	0	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
27	NDN	suppressor	2	0	0	MAGE (PF01454, IPR002190): MAGE family
28	NTRK1	oncoprotein	21	0.216	130.267	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
29	OSBP	interactor	2	1.000	0	Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein PH (PF00169, IPR001849, SM00233): PH domain Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
30	PPFIA2	interactor	13	0.379	28.267	DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745) HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SlyX (PF04102, IPR007236): SlyX TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
31	PPFIA3	interactor	13	0.394	28.700	DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745) T2SSF (PF00482, IPR018076): Type II secretion system (T2SS), protein F SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) Tup_N (PF08581, IPR013890): Tup N-terminal FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 FAM76 (PF16046, IPR032017): FAM76 protein
32	PPFIBP1	oncoprotein	9	0.500	9.869	DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain XkdW (PF09636, IPR019094): XkdW protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding DUF3837 (PF12939, IPR024212): Domain of unknown function (DUF3837)
33	PPFIBP2	interactor	3	0.667	1.000	DASH_Dad1 (PF08649, IPR013958): DASH complex subunit Dad1 DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
34	PPP2CA	suppressor	11	0.364	27.602	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
35	PPP2CB	suppressor	5	0.900	0.400	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
36	PPP2R1A	oncoprotein	10	0.533	12.236	TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
37	PPP2R5D	interactor	7	0.619	4.800	B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
38	PSMC4	interactor	6	0.933	0.333	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) NTPase_1 (PF03266, IPR004948): NTPase CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_16 (PF13191): AAA ATPase domain
39	PSMD1	interactor	7	0.762	2.667	PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat HEAT_2 (PF13646): HEAT repeats
40	PSMD13	interactor	6	0.933	0.333	Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase PCI (PF01399, IPR000717, SM00088): PCI domain
41	PSMD8	interactor	6	0.800	1.500	CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
42	PTPRD	suppressor	4	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Glyco_hydro_46 (PF01374, IPR000400): Glycosyl hydrolase family 46 I-set (PF07679, IPR013098): Immunoglobulin I-set domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase Ig_3 (PF13927): Immunoglobulin domain
43	PTPRF	interactor	6	0.667	2.102	Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST) C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
44	PTPRS	interactor	5	0.700	1.536	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase Ig_3 (PF13927): Immunoglobulin domain
45	SPTAN1	oncoprotein	3	1.000	0	EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
46	TNNT1	protein found in more fusions	2	0	0	Troponin (PF00992, IPR001978): Troponin DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
47	TUBG1	protein found in more fusions	7	0.467	5.833	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
48	TXLNA	protein found in more fusions	6	0.400	5.500	Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
49	XRCC1	interactor	2	1.000	0	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain SPX (PF03105, IPR004331): SPX domain XRCC1_N (PF01834, IPR002706): XRCC1 N terminal domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
50	YWHAB	interactor	4	0.833	0.500	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor

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