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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins POU2F2 (from a repository: Fri Nov 11 23:17:21 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins8 (44.44 %)
The number (and %) of the tumor suppressors2 (11.11 %)
Total number of binary PPIs (saturation %)47 (30.72 %)
The number (and %) of affected PPIs18 (38.30 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI4.111
Assortativity coefficient-0.5197
The network average Clustering coefficient0.538
The number (and %) of a zero Clustering coefficients3 (16.67 %)
The number (and %) of a zero Betweenness Centrality8 (44.44 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: POU2F2 All fusions
: AI654702; BF509229; BE503697; BM423804; AI657122;
Proteins found in more fusions RXRA (see 2 fusions); POU2F2 (see 5 fusions); NR3C1 (see 8 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 POU2F2parental protein180.147191.333Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
2 ARoncoprotein60.4004.167Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
3 ESR1suppressor80.33313.000Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
4 FOXC2oncoprotein200Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
5 FOXJ2interactor31.0000SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
6 FOXS1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
7 GAPDHoncoprotein40.6670.500Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
8 HMGA1oncoprotein30.6670.500AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
9 HMGB2interactor50.4004.667HMG_box_2 (PF09011, IPR009071): HMG-box domain
NOA36 (PF06524, IPR010531): NOA36 protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
10 MNAT1oncoprotein21.0000MAT1 (PF06391, IPR015877): CDK-activating kinase assembly factor MAT1
Mu-like_Com (PF10122, IPR019294): Mu-like prophage protein Com
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
11 NR3C1protein found in more fusions60.5004.667GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
12 PGRsuppressor50.6671.500Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
13 RXRAoncoprotein31.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
14 TBPinteractor70.4008.167TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
15 TEAD2interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
16 TLE4interactor100TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4662 (PF15578, IPR028970): Domain of unknown function (DUF4662)
17 TXNRD1interactor21.0000Glutaredoxin (PF00462, IPR002109): Glutaredoxin
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
18 XRCC6oncoprotein60.5003.500Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

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