Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	54
The number (and %) of the onco-proteins	22 (40.74 %)
The number (and %) of the tumor suppressors	13 (24.07 %)
Total number of binary PPIs (saturation %)	226 (15.79 %)
The number (and %) of affected PPIs	54 (23.89 %)
The number of possible different fusions	15
PPI diameter	2
PPI radius	1
The average degree of PPI	7.370
Assortativity coefficient	-0.2648
The network average Clustering coefficient	0.574
The number (and %) of a zero Clustering coefficients	5 (9.26 %)
The number (and %) of a zero Betweenness Centrality	15 (27.78 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: POU2F1	All fusions : DA179732;
Proteins found in more fusions	RXRA (see 2 fusions); APP (see 4 fusions); PARP1 (see 1 fusions); HCFC1 (see 2 fusions); VDR (see 2 fusions); PRKDC (see 3 fusions); TNF (see 1 fusions); POU2F1 (see 1 fusions); CREB1 (see 2 fusions); RARA (see 4 fusions); THRA (see 3 fusions); NR3C1 (see 8 fusions); SP1 (see 1 fusions); GAPDH (see 2 fusions);

List of the fusions

PPI for parental proteins: POU2F1

All fusions

: DA179732;

Proteins found in more fusions

RXRA (see 2 fusions); APP (see 4 fusions); PARP1 (see 1 fusions); HCFC1 (see 2 fusions); VDR (see 2 fusions); PRKDC (see 3 fusions); TNF (see 1 fusions); POU2F1 (see 1 fusions); CREB1 (see 2 fusions); RARA (see 4 fusions); THRA (see 3 fusions); NR3C1 (see 8 fusions); SP1 (see 1 fusions); GAPDH (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	POU2F1	parental protein	54	0.106	1959.664	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
2	APP	protein found in more fusions	11	0.267	32.167	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3	AR	oncoprotein	12	0.545	11.140	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
4	BRCA1	suppressor	17	0.458	43.358	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
5	BRD7	suppressor	2	1.000	0	HcyBio (PF01837, IPR002708): Homocysteine biosynthesis enzyme, sulfur-incorporation GntR (PF00392, IPR000524, SM00345): Bacterial regulatory proteins, gntR family Presenilin (PF01080, IPR001108): Presenilin Bromodomain (PF00439, IPR001487, SM00297): Bromodomain DUF3512 (PF12024, IPR021900): Domain of unknown function (DUF3512) MAJIN (PF15077, IPR027816): Membrane-anchored junction protein
6	CDK11B	oncoprotein	5	0.667	1.167	DDHD (PF02862, IPR004177, SM01127): DDHD domain DivIC (PF04977, IPR007060): Septum formation initiator Pkinase (PF00069, IPR000719): Protein kinase domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
7	CEBPE	interactor	2	0	0	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
8	CREB1	oncoprotein	10	0.333	18.967	bZIP_1 (PF00170, IPR004827): bZIP transcription factor pKID (PF02173, IPR003102): pKID domain DUF4988 (PF16378, IPR032149): Domain of unknown function
9	ESR1	suppressor	19	0.386	67.415	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
10	FOXC1	suppressor	5	0.500	4.167	TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence Forkhead (PF00250, IPR001766, SM00339): Forkhead domain PAF (PF15715, IPR031444): PCNA-associated factor PRIMA1 (PF16101): Proline-rich membrane anchor 1
11	FOXC2	oncoprotein	5	0.667	1.667	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
12	FOXS1	interactor	4	0.500	2.667	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
13	GAPDH	oncoprotein	8	0.524	7.248	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
14	HCFC1	protein found in more fusions	5	0.667	0.733	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
15	HDAC1	suppressor	16	0.448	35.487	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
16	HMGA1	oncoprotein	8	0.464	9.206	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
17	HOXB13	suppressor	4	0.500	2.667	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain HoxA13_N (PF12284, IPR022067): Hox protein A13 N terminal
18	HOXC4	interactor	4	0.667	1.667	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
19	HOXC9	interactor	2	1.000	0	Hox9_act (PF04617, IPR006711): Hox9 activation region Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
20	HSPA8	oncoprotein	11	0.382	28.500	HSP70 (PF00012, IPR013126): Hsp70 protein
21	IRF9	interactor	4	0.500	3.000	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
22	LMNB1	interactor	2	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain
23	MAGEA10	interactor	1	0	0	MAGE (PF01454, IPR002190): MAGE family SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
24	MNAT1	oncoprotein	4	1.000	0	MAT1 (PF06391, IPR015877): CDK-activating kinase assembly factor MAT1 Mu-like_Com (PF10122, IPR019294): Mu-like prophage protein Com zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
25	NCOR2	oncoprotein	13	0.449	20.984	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
26	NPAT	interactor	3	1.000	0	Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3 TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2 NPAT_C (PF15712, IPR031442): NPAT C terminus
27	NR3C1	protein found in more fusions	11	0.378	20.817	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
28	PARP1	suppressor	14	0.615	13.243	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
29	PBX1	oncoprotein	5	0.500	4.333	PBC (PF03792, IPR005542): PBC domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
30	PGR	suppressor	12	0.673	10.563	Prog_receptor (PF02161, IPR000128): Progesterone receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
31	PKNOX1	suppressor	3	0.667	1.000	Homeobox_KN (PF05920, IPR008422): Homeobox KN domain Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
32	PLK3	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain POLO_box (PF00659, IPR000959): POLO box duplicated region
33	POGZ	interactor	4	0.500	1.733	DDE_1 (PF03184, IPR004875): DDE superfamily endonuclease Rubredoxin (PF00301, IPR024935): Rubredoxin HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain HTH_28 (PF13518): Helix-turn-helix domain zinc_ribbon_4 (PF13717): zinc-ribbon domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
34	POU2AF1	oncoprotein	1	0	0	PD-C2-AF1 (PF09310, IPR015389): POU domain, class 2, associating factor 1
35	PRKACA	interactor	4	0.833	0.400	Pkinase (PF00069, IPR000719): Protein kinase domain
36	PRKDC	protein found in more fusions	14	0.615	13.222	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
37	RARA	oncoprotein	8	0.762	1.789	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
38	RELA	oncoprotein	17	0.483	37.523	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
39	RXRA	oncoprotein	9	0.571	6.717	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
40	SNAPC4	interactor	2	1.000	0	DUF111 (PF01969, IPR002822): Protein of unknown function DUF111 Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
41	SP1	protein found in more fusions	19	0.405	61.556	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
42	SP4	interactor	2	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Macoilin (PF09726, IPR019130): Transmembrane protein PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
43	SPTBN1	suppressor	2	1.000	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Spectrin (PF00435, IPR002017): Spectrin repeat PH_9 (PF15410): Pleckstrin homology domain
44	STAT5B	oncoprotein	5	0.500	2.400	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
45	STIP1	interactor	5	0.800	1.333	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
46	TBP	interactor	10	0.583	9.815	TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
47	TEAD2	interactor	3	0.667	1.000	TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
48	THRA	suppressor	8	0.619	4.106	C1_2 (PF03107, IPR004146): C1 domain zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
49	TLX2	interactor	2	1.000	0	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
50	TNF	oncoprotein	2	0	0	TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
51	TXNRD1	interactor	2	1.000	0	Glutaredoxin (PF00462, IPR002109): Glutaredoxin Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
52	VDR	suppressor	6	0.500	2.917	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
53	XRCC5	suppressor	11	0.689	6.815	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
54	XRCC6	oncoprotein	12	0.600	10.848	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain

B a c k t o T o p ⇑

Fusion ID: Protein names:	POU2F1
Level of PPIs:	or Upload text file:	Update repository

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List of active interactors