Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins POLR2E (from a repository: Sun Dec 4 03:35:20 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PNG file PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 103 The number (and %) of the onco-proteins 22 (21.36 %) The number (and %) of the tumor suppressors 16 (15.53 %) Total number of binary PPIs (saturation %) 946 (18.01 %) The number (and %) of affected PPIs 103 (10.89 %) The number of possible different fusions 22 PPI diameter 2 PPI radius 1 The average degree of PPI 17.456 Assortativity coefficient -0.1687 The network average Clustering coefficient 0.556 The number (and %) of a zero Clustering coefficients 4 (3.88 %) The number (and %) of a zero Betweenness Centrality 8 (7.77 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: POLR2E	All fusions : BQ362075;
Proteins found in more fusions	POLR2F/PIH1D1 (see 1 fusions); URI1 (see 3 fusions); LZTR1 (see 2 fusions); HSP90AA1 (see 2 fusions); EEF1A1 (see 1 fusions); TRIM28 (see 1 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); OFD1 (see 1 fusions); MYC (see 1 fusions); CDH1 (see 3 fusions); POLR2E (see 2 fusions); FOS (see 4 fusions); POLR2A (see 2 fusions); COPS5 (see 1 fusions); PML (see 4 fusions); RPA1 (see 1 fusions); USP11 (see 4 fusions); NEDD4 (see 1 fusions); TRIM29 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	POLR2E	parental protein	103	0.155	4501.446	RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain
2	ARRB1	interactor	11	0.491	10.024	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
3	ARRB2	interactor	16	0.358	32.247	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
4	BARD1	suppressor	13	0.576	9.951	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
5	BRCA1	suppressor	26	0.443	63.723	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6	CCDC8	interactor	17	0.483	24.506	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
7	CDH1	suppressor	7	0.467	2.669	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
8	COPS5	protein found in more fusions	15	0.440	18.318	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
9	CUL3	protein found in more fusions	29	0.294	134.694	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10	CUL7	protein found in more fusions	18	0.493	20.170	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
11	EEF1A1	suppressor	23	0.394	54.074	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
12	ESR1	suppressor	35	0.374	172.023	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
13	FKBP14	interactor	1	0	0	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
14	FOS	oncoprotein	5	0.500	1.682	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
15	GTF2B	interactor	10	0.867	1.509	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
16	GTF2F2	interactor	15	0.590	22.965	TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
17	HSP90AA1	oncoprotein	20	0.339	52.131	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
18	HSP90B1	suppressor	9	0.389	7.828	CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
19	HTATSF1	interactor	6	0.667	2.109	BUD22 (PF09073, IPR015158): BUD22 Conotoxin (PF02950, IPR004214): Conotoxin Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
20	IKBKG	interactor	15	0.352	28.225	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
21	INTS10	interactor	9	1.000	0	NA
22	INTS3	interactor	14	0.692	10.334	SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1 Fn_bind (PF02986, IPR004237): Fibronectin binding repeat Ints3 (PF10189, IPR019333): Integrator complex subunit 3
23	INTS5	interactor	12	0.924	1.004	INTS5_N (PF14837, IPR029445): Integrator complex subunit 5 N-terminus INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus
24	INTS6	suppressor	15	0.676	12.293	VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain INT_SG_DDX_CT_C (PF15300, IPR029307): INTS6/SAGE1/DDX26B/CT45 C-terminus DUF4596 (PF15363, IPR027907): Domain of unknown function (DUF4596)
25	ITCH	interactor	11	0.556	7.202	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
26	LAMB1	interactor	1	0	0	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family YscO (PF07321, IPR009929): Type III secretion protein YscO Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI) Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein Ntox1 (PF15500, IPR029137): Putative RNase-like toxin, toxin_1
27	LZTR1	oncoprotein	7	0.600	2.026	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3 Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_4 (PF13418): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
28	MDC1	suppressor	15	0.467	17.698	FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
29	MED1	interactor	14	0.782	4.821	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
30	MED10	interactor	20	0.800	7.053	Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
31	MED12	oncoprotein	11	0.655	5.100	Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12 Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877) Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
32	MED19	interactor	20	0.801	6.516	Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
33	MED26	interactor	22	0.675	26.051	Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
34	MED28	interactor	18	0.735	16.928	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain Med28 (PF11594, IPR021640): Mediator complex subunit 28
35	MED29	interactor	20	0.784	8.045	Med29 (PF11568, IPR021018): Mediator complex subunit 29
36	MED9	interactor	16	0.858	3.048	Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
37	MYC	oncoprotein	17	0.450	30.037	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
38	NEDD4	suppressor	13	0.470	12.402	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
39	NPHP1	interactor	7	0.733	2.650	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FAM176 (PF14851): FAM176 family Speriolin_N (PF15058, IPR029385): Speriolin N terminus DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
40	NPM1	suppressor	21	0.400	50.705	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
41	OBSL1	interactor	18	0.493	18.453	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
42	OFD1	protein found in more fusions	9	0.643	4.209	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit GrpE (PF01025, IPR000740): GrpE NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein XhlA (PF10779, IPR019715): Haemolysin XhlA DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372) LisH_2 (PF16045, IPR006594): LisH
43	PAAF1	interactor	1	0	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
44	PIH1D1	protein found in more fusions	28	0.370	116.514	PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
45	PML	suppressor	5	0.500	1.619	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
46	POLR1A	interactor	25	0.363	90.211	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
47	POLR1B	interactor	18	0.431	44.848	RNA_pol_Rpa2_4 (PF06883, IPR009674): RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
48	POLR1C	interactor	23	0.451	68.087	RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
49	POLR1D	interactor	14	0.769	5.337	RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
50	POLR2A	protein found in more fusions	56	0.298	469.354	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
51	POLR2B	interactor	52	0.287	449.214	RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 (PF04566, IPR007646): RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 (PF04567, IPR007647): RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
52	POLR2C	interactor	45	0.367	212.830	RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
53	POLR2D	interactor	33	0.462	109.903	RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4 Tfb4 (PF03850, IPR004600): Transcription factor Tfb4
54	POLR2F	protein found in more fusions	39	0.393	196.415	RNA_pol_Rpb6 (PF01192, IPR006110): RNA polymerase Rpb6
55	POLR2G	interactor	38	0.468	100.297	SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
56	POLR2H	interactor	42	0.388	209.293	RNA_pol_Rpb8 (PF03870, IPR005570, SM00658): RNA polymerase Rpb8
57	POLR2I	interactor	28	0.558	45.578	RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS) CpXC (PF14353, IPR025682): CpXC protein
58	POLR2J	interactor	31	0.503	57.961	RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
59	POLR2K	interactor	21	0.674	16.011	DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
60	POLR2L	interactor	29	0.473	67.157	RNA_pol_N (PF01194, IPR000268): RNA polymerases N / 8 kDa subunit
61	POLR2M	interactor	16	0.742	6.985	GCOM2 (PF15328, IPR026213): Putative GRINL1B complex locus protein 2
62	POLR3A	interactor	23	0.478	59.852	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
63	POLR3B	interactor	18	0.621	20.676	RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 (PF04566, IPR007646): RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 (PF04567, IPR007647): RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
64	POLR3C	interactor	14	0.813	4.118	HTH_9 (PF08221, IPR013197): RNA polymerase III subunit RPC82 helix-turn-helix domain NIT (PF08376, IPR013587): Nitrate and nitrite sensing RNA_pol_Rpc82 (PF05645, IPR008806): RNA polymerase III subunit RPC82 HD_4 (PF13328, IPR003607): HD domain
65	POLR3D	interactor	15	0.714	10.124	Atrophin-1 (PF03154, IPR002951): Atrophin-1 family RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
66	POLR3E	interactor	17	0.588	22.621	Sin_N (PF04801, IPR006886): Sin-like protein conserved region DUF2382 (PF09557, IPR019060): Domain of unknown function (DUF2382)
67	POLR3F	interactor	12	0.833	3.005	RNA_pol_Rpc34 (PF05158, IPR007832): RNA polymerase Rpc34 subunit
68	POLR3H	interactor	11	0.964	0.382	RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25 SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
69	POLR3K	interactor	10	0.933	0.675	RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS) zf-ribbon_3 (PF13248): zinc-ribbon domain zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
70	PPP1CA	suppressor	23	0.399	68.572	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
71	PPP1R3A	interactor	7	0.905	0.487	CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
72	PSMB9	interactor	16	0.924	0.894	Proteasome (PF00227, IPR001353): Proteasome subunit
73	RABEP2	interactor	2	1.000	0	Rab5-bind (PF09311, IPR015390): Rabaptin-like protein Rabaptin (PF03528, IPR018514): Rabaptin
74	RECQL5	oncoprotein	12	0.864	2.210	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase RecQ5 (PF06959, IPR010716): RecQ helicase protein-like 5 (RecQ5) SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding TAtT (PF16811, IPR031823): TRAP transporter T-component
75	RNF2	interactor	17	0.342	40.267	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
76	RPA1	suppressor	22	0.443	41.016	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
77	RPA2	oncoprotein	16	0.475	18.632	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
78	RPA3	interactor	17	0.475	18.632	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
79	RPAP3	interactor	25	0.380	80.046	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3 Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
80	RPRD1B	interactor	18	0.608	22.913	CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1 CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3 CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
81	RPS5	interactor	13	0.551	11.768	Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
82	RUVBL1	oncoprotein	25	0.351	85.035	TIP49 (PF06068, IPR010339): TIP49 C-terminus
83	RUVBL2	oncoprotein	31	0.359	131.824	TIP49 (PF06068, IPR010339): TIP49 C-terminus
84	SEC13	interactor	5	0.667	0.376	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
85	SMG1	interactor	7	0.533	2.633	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein XhlA (PF10779, IPR019715): Haemolysin XhlA PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase SMG1 (PF15785, IPR031559): Serine/threonine-protein kinase smg-1
86	SRC	oncoprotein	23	0.489	56.688	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
87	SRPK1	interactor	8	0.536	5.094	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
88	SUPT5H	interactor	23	0.427	61.940	KOW (PF00467, IPR005824, SM00739): KOW motif Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
89	SYT5	interactor	2	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain MLANA (PF14991, IPR029242): Protein melan-A
90	TAF10	interactor	4	0.833	0.200	TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
91	TAF15	oncoprotein	14	0.385	22.574	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) GRP (PF07172, IPR010800): Glycine rich protein family Presenilin (PF01080, IPR001108): Presenilin RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
92	TCEB3	suppressor	16	0.808	4.664	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
93	TRIM28	protein found in more fusions	17	0.442	23.219	ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PHD (PF00628, IPR019787, SM00249): PHD-finger FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
94	TRIM29	protein found in more fusions	7	0.600	1.604	MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family TP2 (PF01254, IPR000678): Nuclear transition protein 2 zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
95	TTI1	interactor	7	0.857	1.200	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat VHS (PF00790, IPR002014, SM00288): VHS domain CLASP_N (PF12348, IPR024395): CLASP N terminal
96	URI1	protein found in more fusions	18	0.478	28.279	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein Prefoldin (PF02996, IPR004127): Prefoldin subunit DUF3835 (PF12927, IPR024325): Domain of unknown function (DUF3835) SCAPER_N (PF16501, IPR032446): S phase cyclin A-associated protein in the endoplasmic reticulum
97	USP11	protein found in more fusions	6	0.800	0.733	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
98	UXT	interactor	9	0.833	2.219	Prefoldin (PF02996, IPR004127): Prefoldin subunit
99	WWOX	suppressor	11	0.527	11.014	adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain
100	XPO1	interactor	28	0.320	122.996	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
101	XRCC5	suppressor	20	0.351	44.335	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
102	ZNRD1	interactor	4	1.000	0	RecR (PF02132, IPR023628): RecR protein RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
103	ZSCAN1	interactor	4	1.000	0	SCAN (PF02023, IPR003309, SM00431): SCAN domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain Tautomerase_2 (PF14552, IPR004370): Tautomerase enzyme

B a c k    t o    T o p ⇑