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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)215
The number (and %) of the onco-proteins127 (59.07 %)
The number (and %) of the tumor suppressors16 (7.44 %)
Total number of binary PPIs (saturation %)1739 (7.56 %)
The number (and %) of affected PPIs215 (12.36 %)
The number of possible different fusions55
PPI diameter2
PPI radius1
The average degree of PPI15.135
Assortativity coefficient-0.2551
The network average Clustering coefficient0.463
The number (and %) of a zero Clustering coefficients10 (4.65 %)
The number (and %) of a zero Betweenness Centrality23 (10.70 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PML All fusions
: AW606071; CF887266;
Proteins found in more fusions TERF2IP (see 1 fusions); MAPK1 (see 1 fusions); HIPK2 (see 1 fusions); NPM1 (see 1 fusions); HDAC7 (see 1 fusions); BCL6 (see 2 fusions); CUL1 (see 3 fusions); CDK6 (see 1 fusions); MYC (see 1 fusions); PIAS2 (see 2 fusions); PSME3 (see 2 fusions); RUNX1 (see 1 fusions); CREBBP/KAT6A (see 10 fusions); ARIH2 (see 2 fusions); PIAS1 (see 2 fusions); RARA (see 4 fusions); SKI (see 1 fusions); HTT (see 1 fusions); RXRA (see 2 fusions); PLOD3 (see 2 fusions); MTOR (see 1 fusions); ZBTB16 (see 3 fusions); SENP1 (see 1 fusions); STAT1 (see 1 fusions); HOMER3 (see 1 fusions); TP53 (see 3 fusions); SUZ12 (see 2 fusions); LMNA (see 3 fusions); FOXO1 (see 1 fusions); NR3C1 (see 8 fusions); TRIM27/MDM2 (see 1 fusions); ATXN1 (see 3 fusions); SQSTM1 (see 5 fusions); NFKB1 (see 2 fusions); SIAH1 (see 1 fusions); SP1 (see 1 fusions); CREBBP (see 5 fusions); STAT3 (see 2 fusions); RNF111 (see 1 fusions); SF1 (see 1 fusions); TOPBP1 (see 2 fusions); RARA/NPM1 (see 1 fusions); POLR2E (see 2 fusions); EGFR (see 2 fusions); KAT5 (see 3 fusions); FOS (see 4 fusions); JAK1 (see 1 fusions); CSNK2A1 (see 1 fusions); SIAH2 (see 1 fusions); EZH2 (see 1 fusions); PML (see 4 fusions); CHD4 (see 6 fusions); PML/RARA (see 20 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PMLparental protein2150.06228748.349zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
2 ACOT8interactor21.00004HBT_3 (PF13622): Thioesterase-like superfamily
3 ADH1Binteractor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
4 ANKRD2interactor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
5 ARID3Ainteractor40.5001.536ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
Nop14 (PF04147, IPR007276): Nop14-like family
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
6 ARIH2protein found in more fusions70.7330.682IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
7 ARNToncoprotein60.4672.494HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
8 ASF1Ainteractor50.5002.778ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
9 ATF2oncoprotein190.35346.425bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
10 ATF7IPoncoprotein60.6003.194TCP (PF03634, IPR005333): TCP family transcription factor
DUF2951 (PF11166, IPR021337): Protein of unknown function (DUF2951)
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
ATF7IP_BD (PF16788, IPR031870): ATF-interacting protein binding domain
fn3_4 (PF16794, IPR003961): Fibronectin-III type domain
11 ATP5J2interactor30.6671.000WRW (PF10206, IPR019344): Mitochondrial F1F0-ATP synthase, subunit f
12 ATRXoncoprotein80.5006.349DDHD (PF02862, IPR004177, SM01127): DDHD domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Zip (PF02535, IPR003689): ZIP Zinc transporter
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
FAM176 (PF14851): FAM176 family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
13 ATXN1protein found in more fusions140.30832.096AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
14 ATXN3interactor110.31117.025Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
15 AURKAoncoprotein180.36838.496Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
16 AXIN1oncoprotein120.43610.854Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
DIX (PF00778, IPR001158, SM00021): DIX domain
AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
17 BANPsuppressor130.47015.958DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
18 BCL2oncoprotein120.50913.709Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
19 BCL6oncoprotein200.42134.068BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
20 C1QTNF6interactor100C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
21 CASP8AP2interactor70.8001.011CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
IncA (PF04156, IPR007285): IncA protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DUF3304 (PF11745, IPR021733): Protein of unknown function (DUF3304)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
22 CCNT1oncoprotein60.7002.500Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
MDFI (PF15316, IPR026134): MyoD family inhibitor
23 CDK1oncoprotein190.35933.563Pkinase (PF00069, IPR000719): Protein kinase domain
24 CDK2oncoprotein260.40761.056Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
25 CDK6oncoprotein160.35229.896Pkinase (PF00069, IPR000719): Protein kinase domain
26 CDKN2Aoncoprotein210.41947.912Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
27 CHD4oncoprotein190.39235.810CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
Coilin_N (PF15862, IPR031722): Coilin N-terminus
28 CHEK2oncoprotein130.40915.788FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
29 CHFRoncoprotein120.41811.565FHA (PF00498, IPR000253, SM00240): FHA domain
Glyco_hydro_92 (PF07971, IPR012939): Glycosyl hydrolase family 92
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
LAX (PF15681, IPR031393): Lymphocyte activation family X
30 COLGALT1interactor40.6671.286Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein)
Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
31 CREBBPoncoprotein520.266431.062Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
32 CSNK1Dinteractor70.6193.169Pkinase (PF00069, IPR000719): Protein kinase domain
33 CSNK2A1oncoprotein330.296144.308Pkinase (PF00069, IPR000719): Protein kinase domain
34 CSNK2A3interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
35 CSNK2Binteractor190.35343.309CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
36 CTNNB1oncoprotein350.212250.323Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
37 CUL1oncoprotein280.271139.812Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
38 DAXXoncoprotein300.305130.532Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
39 DNM2interactor50.5001.817Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
40 DPH7interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
41 DSN1interactor21.0000MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
42 E2F4oncoprotein100.46710.491E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
SPX (PF03105, IPR004331): SPX domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
43 ECT2oncoprotein70.4298.575BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
44 EGFRoncoprotein290.180209.723Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
45 EHMT2interactor90.5716.626CDC45 (PF02724, IPR003874): CDC45-like protein
Pre-SET (PF05033, IPR007728): Pre-SET motif
Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
SET (PF00856, IPR001214, SM00317): SET domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
46 EIF4Eoncoprotein40.5001.238IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
47 ELF4oncoprotein40.6670.536Ets (PF00178, IPR000418, SM00413): Ets-domain
Elf-1_N (PF12310, IPR022084): Transcription factor protein N terminal
48 EME1interactor40.6670.900ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
49 EZH2oncoprotein270.286107.113CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
50 FASoncoprotein110.42210.261Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
51 FBXO3interactor50.8000.833DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525)
Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
SMI1_KNR4 (PF09346, IPR018958, SM00860): SMI1 / KNR4 family (SUKH-1)
F-box-like (PF12937, IPR001810): F-box-like
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
52 FHL3interactor90.4647.179LIM (PF00412, IPR001781, SM00132): LIM domain
Med27 (PF11571, IPR021627): Mediator complex subunit 27
53 FIP1L1oncoprotein50.6000.793Fip1 (PF05182, IPR007854): Fip1 motif
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FAM176 (PF14851): FAM176 family
Auts2 (PF15336): Autism susceptibility gene 2 protein
54 FOSoncoprotein240.32077.715bZIP_1 (PF00170, IPR004827): bZIP transcription factor
55 FOXO1oncoprotein100.5563.379K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
56 GATA1oncoprotein90.6392.434GATA (PF00320, IPR000679, SM00401): GATA zinc finger
Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
57 GATA2oncoprotein110.36420.371GATA (PF00320, IPR000679, SM00401): GATA zinc finger
58 GLIS2interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
59 GOLGA6Ainteractor100DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Erythro-docking (PF09277, IPR015357): Erythronolide synthase, docking
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
60 H2AFXoncoprotein140.36323.709Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
61 H3F3Aoncoprotein90.38914.022Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
62 HDAC1suppressor660.211811.415FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
63 HDAC11interactor60.3336.786Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
64 HDAC2oncoprotein460.249321.554Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
65 HDAC3oncoprotein430.230328.891Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
66 HDAC6oncoprotein200.23462.915Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
67 HDAC7protein found in more fusions140.5138.378Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
68 HHEXoncoprotein21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
69 HIPK2oncoprotein230.35972.793Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
70 HIRAsuppressor40.6671.067Hira (PF07569, IPR011494): TUP1-like enhancer of split
HIRA_B (PF09453, IPR019015): HIRA B motif
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Mcl1_mid (PF12341, IPR022100): Minichromosome loss protein, Mcl1, middle region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
71 HMGXB4oncoprotein30.6670.400DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF4171 (PF13775, IPR025228): Domain of unknown function (DUF4171)
RMP (PF14996, IPR029239): Retinal Maintenance
72 HNRNPUinteractor210.40557.292CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
73 HOMER3protein found in more fusions200COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
WH1 (PF00568, IPR000697, SM00461): WH1 domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
74 HTTprotein found in more fusions130.48511.753HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
75 IER3oncoprotein40.6670.508FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
76 IFI16suppressor150.33336.995HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
77 IKBKEinteractor50.5001.452IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
78 INTS7interactor100DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
SPG48 (PF14764, IPR028222): AP-5 complex subunit, vesicle trafficking
79 JAK1oncoprotein120.41818.255FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
80 JUNoncoprotein400.335190.478bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
81 KAT5oncoprotein310.345109.282MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
82 KAT6Aoncoprotein70.4766.604BUD22 (PF09073, IPR015158): BUD22
MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
PHD (PF00628, IPR019787, SM00249): PHD-finger
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
zf-met (PF12874): Zinc-finger of C2H2 type
83 KLHL20interactor40.6670.667BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
84 KNL1oncoprotein30.6671.000DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
85 KRASoncoprotein100.33316.697Ras (PF00071, IPR001806, SM00173): Ras family
86 LMNAprotein found in more fusions150.50517.793Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
87 MAFoncoprotein80.6671.736bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Maf_N (PF08383, IPR013592): Maf N-terminal region
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
88 MAGEA2interactor40.6670.272MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
89 MAP1LC3Binteractor40.8330.250Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
90 MAP2K4oncoprotein50.6670.500Pkinase (PF00069, IPR000719): Protein kinase domain
91 MAPK1oncoprotein260.293111.749Pkinase (PF00069, IPR000719): Protein kinase domain
92 MAPK11interactor40.5000.494HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Pkinase (PF00069, IPR000719): Protein kinase domain
93 MAPK3oncoprotein180.33850.072Pkinase (PF00069, IPR000719): Protein kinase domain
94 MAPK7oncoprotein60.5001.155Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
95 MDM2oncoprotein490.213500.593Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
96 MED7interactor40.5001.758Med7 (PF05983, IPR009244): MED7 protein
DotU (PF09850, IPR017732): Type VI secretion system protein DotU
97 MRTO4interactor70.4297.483Glu_syn_central (PF04898, IPR006982): Glutamate synthase central domain
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
98 MTORoncoprotein130.33322.397DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
99 MYBoncoprotein150.41027.681Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
LMSTEN (PF07988, IPR012642): LMSTEN motif
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
100 MYConcoprotein470.250410.965HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
101 NACC1interactor60.4002.030BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
BEN (PF10523, IPR018379, SM01025): BEN domain
102 NANPinteractor100HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase
103 NCOA2oncoprotein110.36418.709DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
104 NCOR1oncoprotein320.349137.025BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
105 NCOR2oncoprotein310.389107.416CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
106 NFATC1oncoprotein120.5306.837RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
107 NFKB1oncoprotein220.44838.020Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
108 NPM1oncoprotein330.308162.450Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
109 NR1I3interactor40.8330.286PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
110 NR2C1interactor70.8100.597zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
111 NR3C1protein found in more fusions300.41173.183GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
112 NR4A1suppressor160.33334.807zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
113 NTRK1oncoprotein480.161572.405I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
114 PARK7suppressor120.6006.437DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
115 PCBD2interactor30.6670.667Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
116 PER2suppressor50.8000.867PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region
117 PIAS1suppressor260.30389.340Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
118 PIAS2protein found in more fusions190.38638.310SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
119 PIN1suppressor250.35793.022Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
120 PKMoncoprotein170.39035.043PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
121 PLAGL1oncoprotein80.8210.898zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
122 PLCG1oncoprotein60.6674.286C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
123 PLOD3protein found in more fusions70.4676.5672OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily
Anp1 (PF03452, IPR005109): Anp1
124 PLSCR1interactor40.5001.250Scramblase (PF03803, IPR005552): Scramblase
125 POLR2Eprotein found in more fusions50.5000.611RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain
RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain
126 PPARGoncoprotein330.39796.363zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
127 PPARGC1Ainteractor180.35345.519Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
128 PSMA3interactor180.27960.549Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
129 PSME3protein found in more fusions120.5826.524PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
130 PYCARDsuppressor41.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
131 RAD51interactor120.40020.154Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
132 RANBP2oncoprotein150.42920.281Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693)
IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain
Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
133 RARAoncoprotein380.212270.003zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
134 RB1oncoprotein360.294194.765RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
135 RBCK1interactor40.6670.500GAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
136 RBL2oncoprotein100.4449.206CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
SLH (PF00395, IPR001119): S-layer homology domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
137 RBX1oncoprotein110.42212.809zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
138 RELAoncoprotein390.337191.921DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
139 RFC4interactor70.6671.869AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
140 RFPL4Binteractor40.6670.686SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
141 RNF111suppressor120.40011.269zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
142 RNF125interactor60.4003.515zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
143 RNF4interactor100.4726.902Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
144 RPL11suppressor120.6526.335Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5
Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
145 RPL5oncoprotein140.48722.716Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
146 RUNX1oncoprotein250.34189.574Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
147 RUNX2oncoprotein140.49513.618DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Runt (PF00853, IPR013524): Runt domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
148 RUNX3oncoprotein80.6433.312Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
149 RXRAoncoprotein260.34775.576zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
150 SAP130interactor100.5339.577SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
151 SAP25interactor50.7001.015SAP25 (PF15476, IPR029163): Histone deacetylase complex subunit SAP25
152 SATB1oncoprotein120.47011.557CUT (PF02376, IPR003350, SM01109): CUT domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371)
ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB
CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
153 SENP1protein found in more fusions130.47014.698Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
154 SETDB1interactor90.5286.255MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
155 SF1protein found in more fusions130.27330.236UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
156 SFXN3interactor60.4008.667Mtc (PF03820, IPR004686): Tricarboxylate carrier
157 SH3GL1oncoprotein40.6670.222BAR (PF03114, IPR004148, SM00721): BAR domain
PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
158 SIAH1suppressor150.34122.762Sina (PF03145, IPR018121): Seven in absentia protein family
159 SIAH2oncoprotein120.47310.423Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
160 SIN3Aoncoprotein310.280161.652Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
161 SIRT1oncoprotein320.290135.495DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
162 SKIoncoprotein220.39048.583c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
163 SKILoncoprotein180.36833.558c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
164 SKP1oncoprotein130.38524.239Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
165 SLC1A2interactor21.0000SDF (PF00375, IPR001991): Sodium:dicarboxylate symporter family
DUF2209 (PF09974, IPR014514): Uncharacterized protein conserved in archaea (DUF2209)
166 SMAD2oncoprotein270.38879.620MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
167 SMAD3oncoprotein440.246327.410MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
168 SMARCA4oncoprotein380.314202.665DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
169 SNRNP40interactor40.6671.067WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
170 SNX11interactor21.0000PX (PF00787, IPR001683, SM00312): PX domain
171 SP1protein found in more fusions380.351181.659zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
172 SP100suppressor130.47021.898Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
SAND (PF01342, IPR000770, SM00258): SAND domain
HSR (PF03172, IPR004865): HSR domain; Sp100 domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
173 SPI1oncoprotein140.51612.881Ets (PF00178, IPR000418, SM00413): Ets-domain
p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
174 SQSTM1oncoprotein230.29484.848PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
175 SRFinteractor140.6674.112SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
176 STAT1suppressor200.43337.437SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
177 STAT2oncoprotein50.8000.367SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT2_C (PF12188, IPR022756): Signal transducer and activator of transcription 2 C terminal
178 STAT3oncoprotein300.315122.530SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
179 SUMO1interactor380.207276.789Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
180 SUMO2interactor290.220153.697Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
181 SUMO3interactor110.40013.237Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
182 SUZ12oncoprotein220.31472.922DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
183 SYNE2oncoprotein40.6671.333ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
SlyX (PF04102, IPR007236): SlyX
Spectrin (PF00435, IPR002017): Spectrin repeat
TMPIT (PF07851, IPR012926): TMPIT-like protein
KASH (PF10541, IPR012315): Nuclear envelope localisation domain
HD_5 (PF13487): HD domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
184 TBC1D14interactor21.0000Sds3 (PF08598, IPR013907): Sds3-like
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
RPAP2_Rtr1 (PF04181, IPR007308): Rtr1/RPAP2 family
185 TBX2interactor100K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
T-box (PF00907, IPR001699, SM00425): T-box
TBX (PF12598, IPR022582): T-box transcription factor
186 TBX3oncoprotein60.5001.062T-box (PF00907, IPR001699, SM00425): T-box
TBX (PF12598, IPR022582): T-box transcription factor
187 TCF7L2oncoprotein50.5001.477CTNNB1_binding (PF08347, IPR013558): N-terminal CTNNB1 binding
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
188 TCTN3interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
189 TDGinteractor140.41816.032Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
190 TERF2IPprotein found in more fusions70.3337.500BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
191 TERToncoprotein60.7331.152RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase)
Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
192 TGIF1oncoprotein60.8670.325Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
LRS4 (PF10422, IPR018479): Monopolin complex subunit LRS4
193 TIMM23interactor30.6670.500Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
194 TOMM20interactor50.5004.167RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
195 TOP2Boncoprotein160.45825.104CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DASH_Spc19 (PF08287, IPR013251): Spc19
DNA_gyraseB (PF00204, IPR013506): DNA gyrase B
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Toprim (PF01751, IPR006171, SM00493): Toprim domain
Anophelin (PF10731, IPR018932): Thrombin inhibitor from mosquito
DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
196 TOPBP1protein found in more fusions41.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
197 TOPORSoncoprotein90.47210.258Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
198 TP53oncoprotein910.1362166.004DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
199 TP63suppressor150.48421.144Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
200 TRIM24oncoprotein100.33310.838PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
zf-MYND (PF01753, IPR002893): MYND finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
Imm68 (PF15583, IPR028276): Immunity protein 68
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
201 TRIM27oncoprotein220.32483.953IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
202 TRIM69interactor31.0000DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
203 UBE2Iinteractor740.1561309.243UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
204 UBE2Uinteractor70.3339.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
efb-c (PF12199, IPR021033): Extracellular fibrinogen binding protein C terminal
TMEM154 (PF15102, IPR028064): TMEM154 protein family
205 UBE3Aoncoprotein80.3817.709HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
206 UHRF1interactor150.41825.216PHD (PF00628, IPR019787, SM00249): PHD-finger
SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
207 UQCRQinteractor30.6671.000UcrQ (PF02939, IPR004205): UcrQ family
208 USP7oncoprotein270.289100.875MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
209 WDR5interactor130.29535.608WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
210 WRNoncoprotein120.38211.355DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
Laminin_II (PF06009, IPR010307): Laminin Domain II
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
HTH_40 (PF14493, IPR029491): Helix-turn-helix domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
211 YAP1oncoprotein100.37811.389Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
212 ZBTB16oncoprotein250.33788.043BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
213 ZFYVE9interactor51.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
SARA (PF11409, IPR024608): Smad anchor for receptor activation (SARA)
DUF3480 (PF11979, IPR022557): Domain of unknown function (DUF3480)
214 ZMYM2oncoprotein90.44412.232YHS (PF04945, IPR007029): YHS domain
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
215 ZNF506interactor100Antimicrobial14 (PF08109, IPR012517): Lactocin 705 family
KRAB (PF01352, IPR001909, SM00349): KRAB box
ROS_MUCR (PF05443, IPR008807): ROS/MUCR transcriptional regulator protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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