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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PLP2 (from a repository: Wed Nov 23 16:51:40 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins2 (7.69 %)
The number (and %) of the tumor suppressors1 (3.85 %)
Total number of binary PPIs (saturation %)40 (12.31 %)
The number (and %) of affected PPIs26 (65.00 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.615
Assortativity coefficient-0.3314
The network average Clustering coefficient0.292
The number (and %) of a zero Clustering coefficients16 (61.54 %)
The number (and %) of a zero Betweenness Centrality22 (84.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PLP2 All fusions
: BE762364;
Proteins found in more fusions PLP2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PLP2parental protein260.030568.000MARVEL (PF01284, IPR008253): Membrane-associating domain
2 CCDC155interactor100CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
EF-hand_9 (PF14658): EF-hand domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
3 CD2BP2interactor100GYF (PF02213, IPR003169, SM00444): GYF domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
4 CEP290interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
Fez1 (PF06818): Fez1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HemY_N (PF07219, IPR010817): HemY protein N-terminus
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mnd1 (PF03962, IPR005647): Mnd1 family
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Rho_Binding (PF08912, IPR015008): Rho Binding
Sec20 (PF03908, IPR005606): Sec20
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Swi5 (PF07061, IPR010760): Swi5
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LIDHydrolase (PF10230, IPR019363): Lipid-droplet associated hydrolase
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
CEP209_CC5 (PF16574, IPR032321): Coiled-coil region of centrosome protein CE290
5 CLN8interactor100TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
6 DHODHinteractor21.0000DHO_dh (PF01180, IPR012135): Dihydroorotate dehydrogenase
FMN_dh (PF01070, IPR000262): FMN-dependent dehydrogenase
PASTA (PF03793, IPR005543, SM00740): PASTA domain
7 HNRNPFinteractor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
8 IKBKAPinteractor200IKI3 (PF04762, IPR006849): IKI3 family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
9 ILF3oncoprotein60.4009.000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
10 LACC1interactor100Cu-oxidase_4 (PF02578, IPR003730): Multi-copper polyphenol oxidoreductase laccase
11 LAGE3interactor100Pcc1 (PF09341, IPR015419): Transcription factor Pcc1
12 MRPL30interactor21.0000Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e
13 MRPL41interactor31.0000MRP-L27 (PF09809, IPR019189): Mitochondrial ribosomal protein L27
14 MRPL57interactor100MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
15 MRPL9interactor40.6672.000Ribosomal_L9_N (PF01281, IPR020070): Ribosomal protein L9, N-terminal domain
16 NUDCD2interactor100CS (PF04969, IPR007052): CS domain
DUF3110 (PF11360, IPR021503): Protein of unknown function (DUF3110)
17 PTCD3interactor21.0000PPR (PF01535, IPR002885): PPR repeat
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
18 S100A11suppressor200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
19 SFXN3interactor100Mtc (PF03820, IPR004686): Tricarboxylate carrier
20 SGO2interactor100DivIC (PF04977, IPR007060): Septum formation initiator
Shugoshin_C (PF07557, IPR011515): Shugoshin C terminus
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
Tox-SHH (PF15652, IPR028900): HNH/Endo VII superfamily toxin with a SHH signature
21 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
22 SLC12A4interactor21.0000AA_permease (PF00324, IPR004841): Amino acid permease
SLC12 (PF03522, IPR018491): Solute carrier family 12
23 STT3Binteractor21.0000STT3 (PF02516, IPR003674): Oligosaccharyl transferase STT3 subunit
24 SYNCRIPinteractor40.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
25 TMEM79interactor200MAPEG (PF01124, IPR001129): MAPEG family
26 VKORC1interactor200VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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