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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PLCB1 (from a repository: Mon Dec 5 12:52:12 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins5 (33.33 %)
The number (and %) of the tumor suppressors3 (20.00 %)
Total number of binary PPIs (saturation %)22 (20.95 %)
The number (and %) of affected PPIs15 (68.18 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI2.133
Assortativity coefficient-0.4880
The network average Clustering coefficient0.268
The number (and %) of a zero Clustering coefficients10 (66.67 %)
The number (and %) of a zero Betweenness Centrality14 (93.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PLCB1 All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); PLCB1 (see 1 fusions); CTBP2 (see 2 fusions); SLC9A3R1 (see 2 fusions); GAN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PLCB1parental protein150.022178.000DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
zf-C2H2_assoc (PF16606): Unstructured conserved, between two C2H2-type zinc-fingers
2 BTN2A1interactor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3169 (PF11368, IPR021509): Protein of unknown function (DUF3169)
DUF3213 (PF11491, IPR021583): Protein of unknown function (DUF3213)
Ig_3 (PF13927): Immunoglobulin domain
3 CEP76interactor100Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain
4 CTBP1protein found in more fusions31.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
5 CTBP2protein found in more fusions31.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
6 GANprotein found in more fusions200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
7 GNA11oncoprotein21.0000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
8 GNAQoncoprotein100G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
9 KRIT1suppressor100FERM_M (PF00373, IPR019748): FERM central domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
NUDIX_5 (PF16705, IPR032022): NUDIX, or N-terminal NPxY motif-rich, region of KRIT
10 PCF11interactor100CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
CFIA_Pcf11 (PF11526, IPR021605): Subunit of cleavage factor IA Pcf11
11 PTGER3interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
FtsX (PF02687, IPR003838): FtsX-like permease family
12 SLC9A3R1suppressor31.0000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
13 SPTBN1suppressor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
14 TFCP2interactor100CP2 (PF04516, IPR007604): CP2 transcription factor
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
15 TRPM7interactor200Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Ion_trans (PF00520, IPR005821): Ion transport protein
DUF3893 (PF13032, IPR024996): Domain of unknown function (DUF3893)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM

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