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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ANKRD10, PKMYT1 (from a repository: Sat May 13 09:19:51 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins5 (27.78 %)
The number (and %) of the tumor suppressors4 (22.22 %)
Total number of binary PPIs (saturation %)30 (19.61 %)
The number (and %) of affected PPIs16 (53.33 %)
The number of possible different fusions1
PPI diameter5
PPI radius3
The average degree of PPI2.556
Assortativity coefficient-0.4387
The network average Clustering coefficient0.281
The number (and %) of a zero Clustering coefficients11 (61.11 %)
The number (and %) of a zero Betweenness Centrality12 (66.67 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: PKMYT1,ANKRD10 All fusions
: BF203978;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PKMYT1parental protein130.064223.000Pkinase (PF00069, IPR000719): Protein kinase domain
2 ANKRD10parental protein3062.000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
3 APPBP2interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
4 CCNA2oncoprotein31.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
5 CCNB1oncoprotein31.0000Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
6 CCNB2interactor31.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
7 CDK1oncoprotein50.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
8 ELAVL1oncoprotein4085.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 MAPK10suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
10 MAPK8oncoprotein200DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
11 NXF1interactor200NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
12 PIN1suppressor100Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
13 PLIN3interactor200Perilipin (PF03036, IPR004279): Perilipin family
14 PTENsuppressor2044.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
15 SPINT2suppressor100Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
16 STEAP3interactor21.0000DUF781 (PF05612, IPR008499): Mouse protein of unknown function (DUF781)
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
Ferric_reduct (PF01794, IPR013130): Ferric reductase like transmembrane component
17 THOC2interactor100Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
18 TMEM216interactor30.33352.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANKRD10parental proteinAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)BF203978
2 CCNA2oncoproteinCyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
BF203978
3 CCNB1oncoproteinAdeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
BF203978
4 CCNB2interactorCyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
BF203978
5 CDK1oncoproteinPkinase (PF00069, IPR000719): Protein kinase domainBF203978
6 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)BF203978
7 MAPK10suppressorPkinase (PF00069, IPR000719): Protein kinase domainBF203978
8 MAPK8oncoproteinDUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
BF203978
9 PIN1suppressorRotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
BF203978
10 PKMYT1parental proteinPkinase (PF00069, IPR000719): Protein kinase domainBF203978
11 PLIN3interactorPerilipin (PF03036, IPR004279): Perilipin familyBF203978
12 PTENsuppressorDSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
BF203978
13 SPINT2suppressorKunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domainBF203978
14 STEAP3interactorDUF781 (PF05612, IPR008499): Mouse protein of unknown function (DUF781)
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
Ferric_reduct (PF01794, IPR013130): Ferric reductase like transmembrane component
BF203978
15 TMEM216interactorTransmemb_17 (PF09799, IPR019184): Predicted membrane proteinBF203978

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